Mesenchymal Cell News Volume 8.36 | Sep 13 2016

TOP STORY

Adventitial MSC-Like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

The authors showed that Gli1⁺ cells located in the arterial adventitia are progenitors of vascular smooth muscle cells and contribute to neointima formation and repair after acute injury to the femoral artery. [Cell Stem Cell] Abstract | Press Release | Graphical Abstract

(Ranked by impact factor of the journal)

IN VITRO

A Quiescent, Regeneration-Responsive Tissue Engineered Mesenchymal Stem Cell Bone Marrow Niche Model via Magnetic Levitation

Investigators present a simple bone marrow-like niche model, which comprises of nanomagnetically levitated stem cells cultured as multicellular spheroids within a type I collagen gel. The stem cells maintained are nestin positive and remain quiescent until regenerative demand is placed upon them. [ACS Nano] Abstract

Functional Quantum Dot-siRNA Nanoplexes to Regulate Chondrogenic Differentiation of Mesenchymal Stem Cells

Scientists used SOX9 gene as the target gene and the quantum dot (QD)-based nanomaterial QD-NH2 with a fluorescent tracer function as the gene carrier to transfect siSOX9 into mesenchymal stem cells after sulfosuccinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate activation in vitro and in vivo. [Acta Biomater] Abstract

Inhibition of Bcl-2 Family Members Sensitizes Mesenchymal Chondrosarcoma to Conventional Chemotherapy: Report on a Novel Mesenchymal Chondrosarcoma Cell Line

The authors report on a newly derived mesenchymal chondrosarcoma cell line, MCS170, in which they investigated treatment with the BH3 mimetic ABT-737 alone or in combination with conventional chemotherapy as a possible new therapeutic strategy. [Lab Invest] Abstract

IN VIVO

Adipose-Derived Mesenchymal Stem Cells Promote the Survival of Fat Grafts via Crosstalk between the Nrf2 and TLR4 Pathways

Adipose-derived stem cells (ADSCs) increase the survival of fat grafts, although the underlying mechanisms remain unclear. TLR4^−/− and Nrf2^−/− mice were used to explore the effects of oxidative stress and inflammation on the viability and function of ADSCs in vitro and in vivo. [Cell Death Dis] Full Article

Bone Marrow Mesenchymal Stem Cells of the Intrauterine Growth Restricted Rat Offspring Exhibit Enhanced Adipogenic Phenotype

Although intrauterine nutritional stress is known to result in offspring obesity and metabolic phenotype, the underlying cellular/molecular mechanisms remain incompletely understood. Researchers tested the hypothesis that compared to the controls, the bone marrow-derived mesenchymal stem cells of the intrauterine growth restricted offspring exhibit to a more adipogenic phenotype. [Int J Obes (Lond)] Abstract

Exosomes Derived From Human Adipose Mensenchymal Stem Cells Accelerates Cutaneous Wound Healing via Optimizing the Characteristics of Fibroblasts

Researchers investigated the roles of adipose mesenchymal stem cells-derived exosomes (ASCs-Exos) in cutaneous wound healing. They found that ASCs-Exos could be taken up and internalized by fibroblasts to stimulate cell migration, proliferation and collagen synthesis in a dose-dependent manner, with increased genes expression of N-cadherin, cyclin-1, PCNA and collagen I, III. [Sci Rep] Full Article

Human Fetal Mesenchymal Stem Cell Secretome Enhances Bone Consolidation in Distraction Osteogenesis

Scientists investigated the immunogenicity of using the human mesenchymal stem cell (MSC) secretome on rat cells, the effects of secretome on osteogenic differentiation of rat bone marrow-derived MSCs, and the potential application of human fetal MSC secretome in promoting bone consolidation in a rat distraction osteogenesis model. [Stem Cell Res Ther] Full Article

Implantable Amyloid Hydrogels for Promoting Stem Cell Differentiation to Neurons

Scientists report a new class of amyloid-inspired peptide hydrogels that was designed and based on α-synuclein protein for which hydrogel formation is triggered by various stimuli, such as heating/cooling or changes in pH. The amyloid hydrogels facilitated the attachment and neuronal differentiation of mesenchymal stem cells (MSCs) and assist in the delivery and engraftment of MSCs in the substantia nigra and caudate putamen of a Parkinsonian mouse model. [NPG Asia Materials] Full Article

Secreted Trophic Factors of Mesenchymal Stem Cells Support Neurovascular and Musculoskeletal Therapies

The authors focus on recent investigations that have elucidated trophic mechanisms and shed light on mesenchymal stem cell (MSC) clinical efficacy relevant to musculoskeletal applications. Innate differences due to MSC sourcing may play a role in the clinical utility of isolated MSCs. [Stem Cell Res Ther] Full Article

Effects of Matrix Metalloproteinases on the Fate of Mesenchymal Stem Cells

The reviewers critically discuss the identification of various matrix metalloproteinases and the signaling pathways that affect the differentiation, migration, angiogenesis, and proliferation of mesenchymal stem cells. [Stem Cell Res Ther] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Vericel to Present Data on the Reduction of Ventricular Arrhythmias with Ixmyelocel-T in the ixCELL-DCM Clinical Trial

Vericel Corporation announced the acceptance of an abstract for presentation entitled “Reduction in Ventricular Arrhythmias with Ixmyelocel-T: Results from the ixCELL-DCM Trial”. The poster will be presented by Timothy Henry, M.D., director of cardiology at Cedars-Sinai Heart Institute, principal investigator of the study, and co-author of the poster. [Press release from Vericel Corporation discussing research presented at American Heart Association’s Scientific Sessions 2016, New Orleans] Press Release

Cynata and FUJIFILM Sign Non-Binding Development and Commercialization Term Sheet

Cynata Therapeutics Limited announced the execution of a term sheet with FUJIFILM Corporation of Japan for the development and commercialization of certain Cynata technology, including Cynata’s lead induced pluripotent stem cell derived therapeutic mesenchymal stem cell product, CYP-001. [Cynata Therapeutics Limited] Press Release

Objective Capital Partners Adds CardioCell to Expanding Portfolio of Life Science Companies

Objective Capital Partners announced that it has recently been retained by CardioCell LLC to help manage its growth needs. CardioCell, a global biotechnology company that uses allogeneic stem cells for cardiovascular indications, recently announced positive data from its Phase IIa clinical trial “Safety and Efficacy of Intravenous Infusion of Ischemia-Tolerant Allogeneic Mesenchymal Stem Cells in Patients with Non-ischemic Cardiomyopathy” at the European Society of Cardiology Congress and is currently planning a Phase III study in early 2017. [Objective Capital Partners] Press Release

Illusory Fears Must Not Stifle Chimaera Research

Human–animal chimaeras are essentially research animals that contain transplanted human cells. Such biologically mixed animals have long been used as staple experimental systems in biomedical studies, including cancer and AIDS research. But, for some, adding human stem cells to animal embryos is a step too far — which is why the National Institutes of Health imposed the moratorium, in 2015. Before then, it funded chimaeric embryo studies as long as they did not use primate blastocysts. [Nature World View] Editorial

Why Scientists Must Share Their Research Code

Many scientists worry over the reproducibility of wet-lab experiments, but data scientist Victoria Stodden’s focus is on how to validate computational research: analyses that can involve thousands of lines of code and complex data sets. [Nature News] Editorial

NEW Cell Culture and Downstream Processing World Congress
February 21-22, 2017
Munich, Germany

NEW World Advanced Therapies and Regenerative Medicine Congress
May 17-19, 2017
London, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Early Stage Researchers – Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis (Various Employers)

Postdoctoral Fellow – Role of Stromal Mesenchymal Cells in Tissue Injury/Repair (Institut Pasteur)

Postdoctoral Fellow – Subpopulations of Mesenchymal Stem Cells from the Bone Marrow and Adipose Tissue Sources (University of Miami)

Faculty Positions – Various Areas (Jackson Laboratory)

Postdoctoral Fellow – Immunomodulatory Properties of Mesenchymal Stem Cells (NYU Langone Medical Center-Hansjörg Wyss Department of Plastic Surgery)

Postdoctoral Fellow/Scientist – Osteoblast Biology (Michigan State University)

Postdoctoral Fellowship – Regenerative Medicine/Biomedical Science (University of California, San Francisco)

Postdoctoral Fellow – Immunomodulatory Properties of Mesenchymal Stem Cells (NYU Langone Medical Center)

Postdoctoral Fellow – Stem Cell Functions in the Hematopoietic System and Other Systems Derived from the Mesoderm (University of Illinois at Chicago)

PhD Position – Ultrasound Stimulation of Mesenchymal Stem Cells for Tissue Repair and Regeneration (University of Birmingham)

Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health)

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