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Pulmonary Cell News| Mesenchymal Cell News 8.38 September 27, 2016 | |
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TOP STORYThe authors report a role for growth differentiation factor 11 (GDF11) in bone remodeling. GDF11 treatment leads to bone loss in both young and aged mice. GDF11 inhibits osteoblast differentiation and also stimulates RANKL-induced osteoclastogenesis through Smad2/3 and c-Fos-dependent induction of Nfatc1. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITRODownregulation of CXCL12 in Mesenchymal Stromal Cells by TGFβ Promotes Breast Cancer Metastasis By employing a lung metastasis model of a murine breast cancer, researchers showed that the prometastatic effect of mesenchymal stromal cells was dependent on their response to transforming growth factor β (TGFβ). [Oncogene] Full Article Uptake of iron oxide nanoparticles-loaded bovine serum albumin (Fe3O4/BSA) particles enhanced significantly the osteogenic differentiation of mesenchymal stem cells under a static magnetic field, as evidenced by elevated alkaline phosphatase activity, calcium deposition, and expressions of collagen type I and osteocalcin at both mRNA and protein levels. [Acta Biomater] Abstract The authors explored the role of lysophosphatidic acid (LPA) signaling in cellular events where MSCs were converted into either multiple myeloma (MM)-supportive or MM-suppressive stroma. They found that myeloma cells stimulate MSCs to produce autotaxin, an indispensable enzyme for the biosynthesis of LPA, and LPA receptor 1 and 3 transduce opposite signals to MSCs to determine the fate of MSCs. [Stem Cells] Abstract Human mesenchymal stem/stromal cell (hMSCs) were seeded on top of cartilaginous endplates (CEP) of nucleotomized intervertebral discs of bovine origin and cultured ex vivo up to three weeks. hMSCs migrated from CEP towards the lesion area and significantly increased expression of collagen type II and aggrecan in IVD, namely in the nucleus pulposus. [Sci Rep] Full Article The authors evaluated the differentiation potential and immunogenicity of human placenta-derived mesenchymal stem cells manipulated with osteogenic priming and dedifferentiation process. [Stem Cell Res Ther] Full Article Investigators analyzed in real time, H2O2 signaling in individual h-MSCs, and compared the kinetic parameters of H2O2 management by cells derived from both control and osteoporotic women. [J Cell Biochem] Abstract Scientists investigated the functional role of vanilloid receptor 1 (VR1) in the cardiomyocyte differentiation of bone marrow-derived mesenchymal stem cells, and elucidated the potential molecular mechanisms. [Cardiovasc Ther] Abstract IN VIVOCytocompatibility in vitro and osseointegration ability in vivo of scaffolds were assessed. In vivo evaluations indicated that the depth of bone ingrowth increased over time and no implant dislocation occurred during the experiment. [Sci Rep] Full Article To demonstrate release of active hepatocyte growth factor, enzyme-linked immunosorbent assay, in vitro migration assays and animal studies were performed to demonstrate mesenchymal stem cells migration in vivo, followed by detailed examinations of the immunological effects of the biomaterials. [J Tissue Eng Regen Med] Abstract Researchers investigated the combination effects of cell transplantation and enriched environment (EE) in a model of hypoxic-ischemic brain injury. Two weeks after treatment, levels of astrocyte density and angiogenic factors were increased in mesenchymal stem cell-EE mice, but glial scarring was not increased. [Int J Mol Sci] Full Article | |
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REVIEWSNanopattern-Induced Osteogenic Differentiation of Stem Cells – A Systematic Review The authors reveal the state-of-the-art on the effects of controlled nanoscale topographies on in vitro osteogenic differentiation of mesenchymal stem cells in the absence of osteogenic supplements. [Acta Biomater] Abstract The Mechanosensor of Mesenchymal Stem Cells: Mechanosensitive Channel or Cytoskeleton? The authors discuss the precise role of transient receptor potential melastatin 7 and the cytoskeleton in mechanosensation in mesenchymal stem cells. [Stem Cell Res Ther] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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SCIENCE NEWSAnika Announces Data Presentations on HYALOFAST Hyaluronic Acid-Based Scaffold Anika Therapeutics, Inc. announced four data presentations on HYALOFAST, a biodegradable HA-based scaffold. [Press release from Anika Therapeutics, Inc. discussing research presented at the 13th World Congress of the International Cartilage Repair Society (ICRS), Naples] Press Release | |
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INDUSTRY NEWSSanBio Co., Ltd. announced that it has begun a Phase II clinical trial of regenerative cell medicine SB623 for patients affected by traumatic brain injury in Japan. [SanBio Co., Ltd. (Business Wire)] Press Release Fundación MAPFRE Presents the Results of Personalized Cell Therapy for Treating Spinal Cord Injury Fundación MAPFRE publicly presented the results of the first clinical trial of personalized cell therapy in patients with complete and chronic spinal cord injury, conducted by the team of neurosurgeon Dr. Jesús Vaquero from the Puerta de Hierro University Hospital in Majadahonda. [Fundación MAPFRE] Press Release | |
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POLICY NEWSZimbabwean Scientists Fight to Preserve National Academy Following years of chronic funding shortages and political neglect, the Zimbabwe Academy of Science (ZAS) is on its knees and has made a plea for support from the large Zimbabwean diaspora. The academy has historically survived on donations and membership fees, but this is no longer sustainable, said ZAS head Christopher Mutambirwa at a meeting of Zimbabwean expatriates in Johannesburg, South Africa. At the moment, the ZAS’s activities are voluntary and unpaid. [Nature News] Editorial Four Men and Two Women Are Running for the Top Slot at the World Health Organization The World Health Organization in Geneva, Switzerland, unveiled the names of the six candidates who are vying to succeed Margaret Chan as director-general. [Science Insider] Editorial Worldwide Brain-Mapping Project Sparks Excitement — and Concern In recent years, brain-mapping initiatives have been popping up around the world. They have different goals and areas of expertise, but now researchers will attempt to apply their collective knowledge in a global push to more fully understand the brain. [Nature News] Editorial
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EVENTSNEW Global Forum on Transplantation Research and Technologies NEW Challenges, Solutions and Progress in Stem Cell Medicine Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Position – Pluripotent Stem Cell Research (Stanford University) Research Associate – Mesenchymal (STEMCELL Technologies, Inc.) Research Group Leader Position – Mesenchymal Cancer Biology (Oslo University Hospital) Postdoctoral Fellow – Role of Stromal Mesenchymal Cells in Tissue Injury/Repair (Institut Pasteur) Faculty Positions – Various Areas (Jackson Laboratory) Postdoctoral Fellow/Scientist – Osteoblast Biology (Michigan State University) Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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