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Pulmonary Cell News| Mesenchymal Cell News 8.39 October 4, 2016 | |
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TOP STORYIFNγ Orchestrates Mesenchymal Stem Cells Plasticity through STAT1, STAT3 and mTOR Pathways Researchers dissected the relevant intracellular pathways through which IFNγ affects mesenchymal stem cell (MSC) plasticity and the consequence of their manipulation on MSC functions. [J Allergy Clin Immunol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROInvestigators report that mesenchymal stromal cells (MSCs) express and secrete PD-L1 and PD-L2 and that this is regulated by exposure to interferon γ and tumor necrosis factor alpha. MSCs, via their secretion of programmed death-1 ligands, suppress the activation of CD4+ T cells, down-regulate interleukin-2 secretion and induce irreversible hyporesponsiveness and cell death. [Stem Cells] Abstract The effects of an experimental pulp-capping material composed of an antibacterial resin monomer and Portland cement on the viability, adhesion, migration, and differentiation of human dental pulp stem cells were examined. [Sci Rep] Full Article Cartilage was devitalized using high hydrostatic pressure treatment and the potential for revitalisation with chondrocytes and mesenchymal stem cells was investigated. [Sci Rep] Full Article Using a three-dimensional in vitro Matrigel plug model, the authors observed how various presentation schedules of platelet derived growth factor (PDGF) and bone morphogenetic protein (BMP)-2 influenced tubule formation by human mesenchymal stem cells and human umbilical vascular endothelial cells. They observed that sequential presentation of PDGF to BMP-2 led to increased tubule formation over simultaneous delivery of these growth factors. [Tissue Eng Part A] Abstract Scientists demonstrated that human embryonic stem cell-derived mesenchymal stem cells (ESC-MSCs) showed similar morphology and cell surface markers compared to bone marrow-derived MSCs. ESC-MSCs exhibited a higher growth rate during early in vitro expansion, along with adipogenic and osteogenic differentiation potential. [Stem Cells Dev] Abstract Researchers investigated the enhanced effects of hepatocyte growth factor (HGF)-modified mesenchymal stem cells (MSCs) on ischemia/reperfusion-induced acute lung injury. Rat bone marrow-derived MSCs were successfully transfected to express HGF. HGF modification did not affect the characteristics of MSCs, and increased MSC viability, and inhibit the proinflammatory phenotype of MSCs in the inflammatory condition. [Gene Ther] Abstract Scientists determined whether interleukin-1β (IL-1β) can induce the differentiation of mesenchymal stem cells (MSCs) to cardiomyocytes. MSCs were derived from bone marrow, propagated and then cultured in differentiation medium supplemented with 5-azacytidine and IL-1β. [Biol Chem] Abstract IN VIVORestoration of Corneal Transparency by Mesenchymal Stem Cells The authors investigated the potential of mesenchymal stem cells (MSCs) to restore corneal transparency following ocular injury. Using an in vivo mouse model of ocular injury, they report that MSCs have the capacity to restore corneal transparency by secreting high levels of hepatocyte growth factor. [Stem Cell Reports] Full Article | Graphical Abstract | Press Release Mesenchymal Stem Cells Stimulate Intestinal Stem Cells to Repair Radiation-Induced Intestinal Injury Investigators found that, following exposure to radiation, transplantation of mesenchymal stem cells improved the survival of mice, ameliorated intestinal injury and increased the number of regenerating crypts. [Cell Death Dis] Full Article | |
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REVIEWSHyaluronic Acid (HA) Scaffolds and Multipotent Stromal Cells (MSCs) in Regenerative Medicine The authors discuss the use of hyaluronic acid-based scaffolds together with multipotent stromal cells, as a very promising tool in regenerative medicine. [Stem Cell Rev] Abstract Mesenchymal Stem Cells and Vascular Regeneration The authors summarize current progress in characterizing the in vivo identity of mesenchymal stem cells (MSCs), discuss mechanisms involved in cell-based therapy utilizing MSCs, and explore current and future strategies for vascular regeneration. [Microcirculation] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSDr. Allen Eaves of STEMCELL Technologies Inc. Named EY Entrepreneur Of The Year™ Pacific 2016 Dr. Allen Eaves, Chairman, President and Chief Executive Officer of STEMCELL Technologies, a global biotechnology company that supplies tools and services to enable life science research, is this year’s Entrepreneur Of The Year Pacific winner. [Ernst & Young (CNW Group Ltd.)] Press Release BioBridge Global-Led Biotech Team Awarded $7.8 Million Army Contract A four-organization biotech group led by San Antonio-based nonprofit BioBridge Global has been awarded a $7.8 million contract from the Medical Technology Enterprise Consortium. The funds will enable the development of large-scale manufacturing capabilities for clinical-grade stem cells for research and therapeutic use. [BioBridge Global] Press Release Medicine Nobel for Research on How Cells ‘Eat Themselves’ Molecular biologist Yoshinori Ohsumi has won the 2016 Nobel Prize in Physiology or Medicine for his work in the field of autophagy: the processes by which the cell digests and recycles its own components. [Nature News] Editorial | Press Release | |
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POLICY NEWSDemocratic Databases: Science on GitHub Scientists are turning to a software-development site to share data and code. [Nature Toolbox] Editorial Biologists Plan Scoring System for Antibodies Biomedical experts plan to create a scoring system that will help researchers choose reliable antibodies for their experiments. The only problems: figuring out how such a ranking would work — and getting manufacturers to adopt the standard. [Nature News] Editorial UK Bioethicists Eye Designer Babies and CRISPR Cows From designer babies to engineered mosquitoes, advances in genome-editing technologies such as CRISPR–Cas9 have raised the possibility of tremendous scientific advances — and serious ethical concerns. [Nature News] Editorial
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EVENTSNEW Advances in Cell Engineering, Imaging and Screening Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Gene Therapy (UC Davis) Research Associate – Mesenchymal (STEMCELL Technologies, Inc.) Faculty Position – Pluripotent Stem Cell Research (Stanford University) Research Group Leader Position – Mesenchymal Cancer Biology (Oslo University Hospital) Postdoctoral Fellow – Role of Stromal Mesenchymal Cells in Tissue Injury/Repair (Institut Pasteur) Faculty Positions – Various Areas (Jackson Laboratory) Postdoctoral Fellow/Scientist – Osteoblast Biology (Michigan State University) Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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