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Pulmonary Cell News| Mesenchymal Cell News 9.00 January 3, 2017 | |
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TOP STORYIdiopathic pneumonia syndrome (IPS) is a serious and life-threatening lung complication following allogeneic hematopoietic stem cell transplantation and currently no effective therapies exist. The authors sought to determine whether transplantation of allogeneic murine compact bone derived-mesenchymal stem cells (CB-MSCs) could prevent the development of IPS. They found that allogeneic CB-MSCs effectively controlled the occurrence of IPS due to its profound immunomodulatory capacity. [Cell Physiol Biochem] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROAccelerated Bone-Regeneration by Two Photon Photoactivated Carbon Nitride Nanosheets Researchers report that red-light absorbing carbon nitride (C3N4) sheets lead to remarkable proliferation and osteogenic differentiation by runt-related transcription factor 2 activation, a key transcription factor associated with osteoblast differentiation. This fast bone-regeneration was attributed to the deep penetration strength of red-light into cellular membranes via tissue and the resulting efficient cell stimulation by enhanced photocurrent upon two-photon excitation of C3N4 sheets near cells. [ACS Nano] Abstract | Graphical Abstract The authors aimed to investigate the effect of the structures of crosslinkers on the in vitro chondrogenic differentiation of bone mesenchymal stem cells in hyaluronic acid-based hydrogels. [ACS Appl Mater Interfaces] Abstract Proteasome Activation Enhances Stemness and Lifespan of Human Mesenchymal Stem Cells Scientists revealed a significant age-related decline in proteasome content and peptidase activities, accompanied by alterations of proteasomal complexes. Additionally, they showed that senescence and the concomitant failure of proteostasis negatively affects stemness. Remarkably, the loss of proliferative capacity and stemness of human adult mesenchymal stem cells can be counteracted through proteasome activation. [Free Radic Biol Med] Abstract | Graphical Abstract Investigators demonstrated for the first time that electrical stimulation enhances expression levels of chondrogenic markers, such as type II collagen, aggrecan, and Sox9, and decreases type I collagen levels, thereby inducing differentiation of mesenchyme stem cells into hyaline chondrogenic cells without the addition of exogenous growth factors. [Sci Rep] Full Article Scientists investigated the effect of human palatine tonsil-derived mesenchymal stem cells on estradiol-induced B-cell responses in vivo and in vitro. [Cell Mol Immunol] Abstract LL-37 Boosts Immunosuppressive Function of Placenta-Derived Mesenchymal Stromal Cells Researchers investigated the effects of LL-37 upon the proliferation and migratory capacity of human placenta-derived MSCs (pMSCs) by MTT and wound scratch assays. The influence of LL-37 over the immunosuppressive function of pMSCs was investigated using CFSE cell division kit. [Stem Cell Res Ther] Full Article Mesenchymal Stem Cells Cultured on Magnetic Nanowire Substrates The interface between the human mesenchymal stem cells (hMSCs) and iron nanowires (NWs) was studied using scanning electron microscopy. Investigators showed that hMSCs underwent a re-organization of actin filaments that translated into a change from an elongated to a spherical cell shape. [Nanotechnology] Abstract The authors investigated pargyline, an inhibitor of lysine-specific demethylase 1, which mainly catalyzes the demethylation of the di- and mono-methylation of H3K4. They demonstrated that 1.5 mmol·L−1 pargyline was the optimal concentration for the osteogenic differentiation of human bone marrow mesenchymal stem cells. [Bone Res] Full Article Bio-Active Molecules Modified Surfaces Enhanced Mesenchymal Stem Cell Adhesion and Proliferation Investigators evaluated the behavior of human bone marrow mesenchymal stem cells on glass substrates modified with fibronectin, collagen, RGD peptides and designed peptide as bio-active molecules. [Biochem Biophys Res Commun] Abstract | Graphical Abstract IN VIVOScientists examined the efficacy and safety of autologous bone marrow-derived mesenchymal stem cells and mononuclear cells transplantation in type 2 diabetes mellitus and explores the alterations in glucose-insulin homeostasis by metabolic studies. [Stem Cells Dev] Abstract | |
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REVIEWSOsteogenic Differentiation in Healthy and Pathological Conditions This authors focus on the osteogenic differentiation of mesenchymal stem cells, bone formation and turn-over in good and ill skeletal fates. [Int J Mol Sci] Full Article | Graphical Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSKeck School of Medicine Receives $2.5 Million Grant for Translational Osteoarthritis Research Keck School of Medicine of the University of Southern California is one of four institutions to receive a multi-million dollar grant from the California Institute for Regenerative Medicine for translational research projects. The $2.5 million grant will support potential osteoarthritis therapies that could significantly impact standards of care for the disease. [University of Southern California] Press Release Vivex Biomedical, Inc. has received level II HCPCS Q-Code for Cygnus. Cygnus, an amniotic tissue matrix with innate regenerative capability to support healing, is a product that is available in multiple sizes for multiple uses. Cygnus’ amnion patch is an immune-privileged tissue with proven clinical success in regenerative healing. [Vivex Biomedical, Inc.] Press Release | |
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POLICY NEWSArgentina’s Researchers Occupy Science Ministry Hundreds of young researchers occupied Argentina’s science ministry in Buenos Aires last month, angry at budget cuts that they say have denied them permanent jobs at the country’s National Scientific and Technical Research Council. The occupation was the most extreme action yet by Argentinian scientists after months of protests at last year’s budget, the first under President Mauricio Macri. And the occupation seems to have paid off, in part: many of those involved have been offered extensions to their fellowships. [Nature News] Editorial Scientists in Germany, Peru and Taiwan to Lose Access to Elsevier Journals Thousands of scientists in Germany, Peru and Taiwan are preparing for a new year without online access to journals from the Dutch publishing giant Elsevier. Contract negotiations in both Germany and Taiwan broke down in December, while Peru’s government has cut off funding for a licence. [Nature News] Editorial
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EVENTSNEW Keystone Symposium: Lipidomics and Bioactive Lipids in Metabolism and Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Assistant Professor – Cardiovascular Repair (Bone Marrow Stem Cells) (University of Cincinnati) NEW Visiting Assistant Professor – Biology (Molecular or Cellular) (Colgate University) NEW Principle Investigator – Mechanobiology Institute (University of Singapore) NEW Sequencing Specialist – Stem Cell and Developmental Biology (University of Copenhagen) NEW Postdoctoral Research Associate – Stem Cell Biology (University of Nebraska) NEW Associate or Senior Editor – Stem Cells/Cell Biology (Nature Communications) NEW Independent Research Group Leaders – Stem Cell Science (University of Cambridge) NEW Tenure Track Faculty Position – Stem Cell Biology & Regenerative Medicine (Stanford University) Postdoctoral Position – Mesenchymal Stem Cells (University Southern California) Scientist – Upstream Process Development-Mesenchymal Stem Cell (Codiak BioSciences) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mesenchymal Cell News Volume 9.00 | Jan 3 2017
