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Pulmonary Cell News| Mesenchymal Cell News 9.08 February 28, 2017 | |
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TOP STORYFOXP1 Controls Mesenchymal Stem Cell Commitment and Senescence during Skeletal Aging Investigators used molecular and genetic approaches to investigate the role of forkhead box P1 (FOXP1) in transcriptional control of mesenchymal stem/progenitor cell (MSC) senescence. In bone marrow MSCs, FOXP1 expression levels declined with age in an inverse manner with those of the senescence marker p16INK4A. [J Clin Invest] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROIn order to identify the mechanisms by which skeletal maturity alters the mechanosensitivity of mesenchymal stromal cells (MSCs) and the implications for osteogenesis and angiogenesis during bone formation, researchers compared the response of MSCs derived from children and skeletally-mature healthy adults cultured on soft and stiff collagen-coated polyacrylamide substrates. [Acta Biomater] Abstract | Press Release | Graphical Abstract The authors investigated the mTOR pathway, which is involved in CD25 expression in T cells. They showed that mesenchymal stromal cells inhibited CD25 expression, which was restored in the presence of an inducible nitric oxide synthase inhibitor. [Cell Death Dis] Full Article To analyze the expression of superoxide dismutase in tumor stroma, scientists characterized stromal cells from the thyroid. They reported mutually exclusive desmoplasia and inflammation in papillary and follicular thyroid cancers and the presence of multipotent mesenchymal stem/stromal cells in non-carcinogenic thyroids and papillary thyroid cancer. [Sci Rep] Full Article By modulating the expression of SMAD2, SMAD3 and SMAD4 in human bone marrow-derived mesenchymal stem cells, researchers investigated their role in transforming growth factor-β (TGFβ)-induced chondrogenesis. Activation of TGFβ signaling, represented by SMAD2 phosphorylation, was decreased by SMAD2 knockdown and highly increased by SMAD2 overexpression. [Sci Rep] Full Article Aging reduces mesenchymal stromal cells (MSCs) immunopotency potentially limiting their therapeutic utility. The mechanisms that mediate the effect of age on MSCs immune-regulatory function remain elusive and were the focus of this study. MSCs from elderly subjects were found to exhibit a diminished capacity to suppress the proliferation of activated T cells. Soluble factors and, to a lesser extent, direct cell-cell contact mechanisms mediated the MSCs:T-cell suppression. [Stem Cells Transl Med] Full Article IN VIVOInvestigators wished to test whether intravenously-administered mesenchymal stem cells (MSCs) reduce LV dysfunction both post-AMI and in ischemic cardiomyopathy, and that these effects are caused, at least partly, by systemic anti-inflammatory activities. Intravenous MSCs eliminated the progressive deterioration in LVEF, LVEDV and LVESV. MSCs significantly decreased natural killer cells in the heart and spleen, and neutrophils in the heart. [Circ Res] Abstract Researchers designed assays to explore the responsiveness of mesenchymal stem cells (MSC) to immunological cues to address the immunomodulatory properties of MSC, one of their primary modes of therapeutic activity in traumatic brain injury. Their results showed intrinsic differences in the immunomodulatory capacity of MSC preparations from different bone marrow and amniotic fluid donors. [Stem Cells] Abstract The authors investigated the mechanism of action of PDA-002 in inducing angiogenesis using a mouse hind-limb ischemia model. They showed that PDA-002 improved blood flow and promoted collateral vessel formation in the injured limb. [Stem Cells] Abstract Scientists aimed to isolate exosomes from bone marrow-derived mesenchymal stem cells (BMSC) and tested them in a rat optic nerve crush model. Treatment of primary retinal cultures with BMSC-exosomes demonstrated significant neuroprotective and neuritogenic effects. [Stem Cells Transl Med] Full Article The study was designed to explore the potential role of mesenchymal stem cells (MSCs) in sepsis-induced cardiac dysfunction. In vivo bioluminescence imaging revealed 80% acute donor cell death of bone marrow-derived MSCs within three days after transplantation. [Cell Death Discov] Full Article | |
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REVIEWSIn light of the escalating need for culturing human adipose-derived mesenchymal stem cells (hASCs) under their physiological condition, the authors summarize the most recent advances in the hypoxia effect on hASCs. [Cell Mol Life Sci] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSCBMG Awarded $2.29 Million Grant from the California Institute for Regenerative Medicine Cellular Biomedicine Group Inc. (CBMG) announced that the governing Board of the California Institute for Regenerative Medicine, California’s stem cell agency, has awarded the company $2.29 million to support pre-clinical studies of AlloJoinTM, CBMG’s “Off-the-Shelf” Allogeneic Human Adipose-Derived Mesenchymal Stem Cells for the treatment of Knee Osteoarthritis in the United States. [Cellular Biomedicine Group Inc.] Press Release Cancer Prevention & Research Institute of Texas Awards 14 New Grants The CPRIT Scholars recruitment grants, totaling $22 million, include three to recruit established cancer scientists and two to bring first-time, tenure-track faculty members to academic institutions in Texas. [Cancer Prevention & Research Institute of Texas] Press Release Bristol-Myers Squibb Company announced that Columbia University Medical Center and Peter MacCallum Cancer Centre have joined the II-ON, a global peer-to-peer collaboration between Bristol-Myers Squibb and academia that aims to advance Immuno-Oncology science and translational medicine to improve patient outcomes. [Bristol-Myers Squibb Company] Press Release | |
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POLICY NEWSTrump’s 2018 Budget Will Squeeze Civilian Science Agencies The chunk of the federal budget that includes most of the U.S. government’s spending on basic science would shrink by 10.5% in 2018 under a plan outlined by President Donald Trump and administration officials. [ScienceInsider] Editorial UK Scientists Welcome Changes to Controversial Research Reforms Amendments aim to protect autonomy and the independence of research funders from political interference. [Nature News] Editorial
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EVENTSNEW 2nd Global Cancer Summit 2017 NEW 2nd International Conference on Stem Cells Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Cell Biology (University of Oslo) NEW Postdoctoral Fellow – 3D Bone Marrow (AstraZeneca) Postdoctoral Associate – Biomaterials (University of Minnesota) Assistant and Associate Professors – Regenerative & Cancer Cell Biology (Albany Medical College) Associate/Assistant Professor(s) – Biomedical Sciences (The Chinese University of Hong Kong) Postdoctoral Positions – Cancer Proteomics & Bioinformatics (University of British Columbia) Faculty Positions – Bone Biology (Vanderbilt Department of Medicine) Senior Scientist – Discovery Oncology (Genentech Research) Tenure-Track Faculty Positions – Department of Biomedical Sciences (University of Pennsylvania) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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