Mesenchymal Cell News 9.15 April 18, 2017 | |
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TOP STORYResearchers demonstrated that novel hybrid materials consisting of gelatin-derived graphene and silicate nanosheets of Laponite are biocompatible and promote osteogenic differentiation of MSCs. [ACS Appl Mater Interfaces] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROActivation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease Scientists identified IRF1 as differentially regulated between primary and in vitro-derived genetically matched adipocytes. Utilizing adipose-derived mesenchymal progenitors, they demonstrated that expression of IRF1 in adipocytes indeed contributes to upregulation of inflammatory processes, both in vitro and in vivo. [Stem Cell Reports] Full Article | Graphical Abstract The authors showed that highly suppressive human adipose tissue-derived mesenchymal stem cells (AdMSC) displayed and induced a differential immunologic profile. Upon ongoing AdMSC suppressive activity, they promoted (i) early correlated inhibition of IFN-γ and TNF-α production, along IL-10 increase, (ii) CD73+Foxp3+Treg subset expansion, and (iii) specific correlations between gene expression increases. [Sci Rep] Full Article Researchers tested the hypothesis that pre-treatment with inflammatory cytokines can prime mesenchymal stem cells (MSCs) towards an anti-inflammatory and pro-trophic phenotype in vitro. MSCs primed with interleukin (IL)-1α or IL-1β showed increased secretion of granulocyte-colony stimulating factor, which was blocked by IL-1Ra. [Stem Cell Res Ther] Full Article Investigators demonstrated that the interaction between miR-450a-5p and miR-28-5p and signal transducer and activator of transcription 1 (STAT1) mRNA correlates with the osteoblastic differentiation of mesenchymal stem cells from human exfoliated deciduous teeth. [J Cell Biochem] Abstract Absence of NUCKS Augments Paracrine Effects of Mesenchymal Stem Cells-Mediated Cardiac Protection The authors investigated the potential mechanisms of the nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS) in regulation of the profiles of bone marrow-derived mesenchymal stem cells (BM-MSCs) secretion and compared the therapeutic efficacy of NUCKS-/-– and wide type-BM-MSCs in myocardial infarction. [Exp Cell Res] Abstract IN VIVOTo develop an alternative therapy for acute liver failure, mesenchymal stem cell (MSC) seeded regenerated silk fibroin (RSF) matrices were evaluated in vitro and in vivo. Scientists found that MSCs exhibited good biocompatibility with RSF and differentiated to hepatocyte-like cells in vitro. Liver functions of the mice in the experimental group were significantly improved than the control group. [ACS Appl Mater Interfaces] Abstract Bone Marrow Mesenchymal Stem Cells Combine with Treated Dentin Matrix to Build Biological Root To assess the odontogenic and osteogenic potential of jaw bone marrow mesenchymal stem cell (JBMMSCs), cells were induced by treated dentin matrix (TDM) extraction in vitro and combined with TDM in vivo. PCR and Western Blotting showed odontogenic and osteogenic makers were significantly enhanced in varying degrees after induced by TDM extraction in vitro. In vivo, JBMMSCs expressed both odontogenic and osteogenic-related protein, and the latter showed stronger positive expression. [Sci Rep] Full Article Investigators hypothesized that human umbilical cord-derived MSCs (hUC-MSCs) would improve survival in experimental neonatal sepsis. They found that treatment with either hUC-MSCs or preconditioned hUC-MSCs significantly increased survival. [Stem Cells Dev] Abstract Preconditioning of mesenchymal stem cells (MSCs) with melatonin (MT) has shown promising results in animal models of myocardial infarction, renal ischemia and cerebral ischemia. Scientists used this strategy in the liver fibrosis induced by CCl4. The CCl4 + MT-bone marrow-derived MSCs group showed higher percentage of glycogen storage but lower percentage of collagen and lipid accumulation. [Cell Tissue Res] Abstract Researchers investigated whether microRNA-146a (miR-146a) influences the secretion of vascular endothelial growth factor (VEGF) and angiogenesis of mesenchymal stem cells (MSCs). Their data indicated that miR-146a-transfected human MSCs decreased the expression of neurofibromin 2, an inhibitor of p21-activated kinase-1. [J Vasc Res] Abstract | |
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REVIEWSMesenchymal Stem Cells in Obesity: Insights for Translational Applications The authors discuss the current understanding of mesenchymal stem cells in adipogenesis and their potential clinical applications for obesity. [Lab Invest] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSSentien Announces Active IND for SBI-101 in Patients with Acute Kidney Injury Sentien announced that the company’s investigational new drug (IND) application for SBI-101 for the treatment of adult patients with acute kidney injury is now active. [Sentien Biotechnologies, Inc.] Press Release Intrinsic Imaging Awarded GIST Clinical Trial for the Treatment of Gastrointestinal Stromal Tumors Intrinsic Imaging, LLC announced that it has been awarded a multi-year clinical trial for the treatment of gastrointestinal tumors (GIST). [Intrinsic Imaging, LLC.] Press Release | |
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POLICY NEWSFrench-Election Fears Unite Scientists in Defense of Liberal Democracy For scientists in France, the presidential contest is often a chance to debate research and science-related issues. When Nicolas Sarkozy was elected a decade ago, for example, university reforms and environmental policy featured prominently in the campaigns. But this time, science has barely been mentioned — elbowed out by political scandals and the rise of Marine Le Pen’s far-right Front National party. [Nature News] Editorial Republican Scientists Negotiate the Trump Era Conservative academics face a growing tension between their politics and the liberal atmosphere on many US campuses. [Nature News] Editorial With This New System, Scientists Never Have to Write a Grant Application Again Almost every scientist agrees: Applying for research funding is a drag. Writing a good proposal can take months, and the chances of getting funded are often slim. Funding agencies, meanwhile, spend more and more time and money reviewing growing stacks of applications. That’s why two researchers are proposing a radically different system that would do away with applications and reviews; instead scientists would just give each other money. [ScienceInsider] Editorial
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EVENTSNEW ISSCR Annual Meeting 2017 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Part-Time Research Assistant – Mesenchymal Stem/Stromal Cell Research (NUI Galway) Postdoctoral Position – Craniofacial Molecular Biology (University of Southern California) Postdoctoral Researcher – Sequencing Analysis of Mesenchymal Tumors (University of Oxford) Postdoctoral Fellow – Cardiopulmonary Molecular Biology (Hannover Medical School) Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University) Postdoctoral Fellow – Tissue Engineering (University of California, Davis) Assistant/Associate Professors – Bone Biology (University of Michigan) Postdoctoral Fellow – Bone Biology and Bioinformatics (Stanford University) Postdoctoral Fellow – Bone Regeneration and Stem Cell Biology (New York University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mesenchymal Cell News Volume 9.15 | Apr 18 2017