Mesenchymal Cell News 9.16 April 25, 2017 | |
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TOP STORYInvestigators hypothesized that a nitric oxide (NO)-releasing polymer could boost the proangiogenic compositions of exosomes and enhance their proangiogenic capacity. Their results demonstrated that exosomes, released from human placenta-derived mesenchymal stem cells by NO stimulation, augmented the angiogenic effects of human umbilical vein endothelial cells in vitro. [Biomaterials] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROScientists found that Jagged1 was the sole Notch ligand packaged into mesenchymal stem cell (MSC) exosomes and was more abundant in hypoxia inducible factor (HIF)-MSCs than in MSC controls. The addition of Jagged1-containing exosomes from MSCs and HIF-MSC cultures to endothelial cells triggered transcriptional changes in Notch target genes and induced angiogenesis in an in vitro model of capillary-like tube formation, and both processes were stimulated by HIF-1α. [Stem Cells] Abstract Researchers systematically compared the morphologic characteristics, immunophenotypes and the adipogenic differentiation of mesenchymal stem cells (MSCs) derived from umbilical cord (UC), adipose tissue (Ad) and bone marrow (BM). They found that the three tissues-derived MSCs displayed decreased adipogenic capacity in the order: Ad-MSC > BM-MSC > UC-MSC, and no morphologic and immunophenotypic differences were observed. [Sci Rep] Full Article Investigators report an easy way to control Ca2+ oscillations in mesenchymal stem cells, through their cancellation or the addition of supplementary Ca2+ spikes. The direct link between microsecond electric pulse(s) delivery and the occurrence/cancellation of cytosolic Ca2+ spikes allowed them to mimic and regulate the Ca2+ oscillations in the cells. [Stem Cell Res Ther] Full Article The authors compared the effects of murine MSCs from bone marrow (BM), adipose tissue (AD), and lung tissue (LUNG) on inflammatory and remodeling processes in experimental allergic asthma. Intratracheal administration of MSCs from BM, AD, and LUNG were differentially effective at reducing airway inflammation and remodeling and improving lung function comparably reduced inflammation and fibrogenesis in the asthma model. [Stem Cells Transl Med] Full Article Investigators aimed to elucidate osteogenic effects of two silica-based xerogels with different degrees of bioactivity on human bone-derived mesenchymal stromal cells. The results referred to the capacity of the bone-derived stromal cells to overcome calcium deficiency even though proliferation, migration and osteogenic differentiation capabilities were diminished. [Biomed Mater] Abstract IN VIVOScientists showed in mice that transglutaminase 2 (TG2) and Factor XIII-A (FXIII-A) control monocyte-macrophage cell differentiation into osteoclasts as well as RANKL production in mesenchymal stem cells and in adipocytes. [Cell Death Differ] Abstract The authors investigated whether hypoxic preconditioning (HPC) improved the functional survival of bone marrow mesenchymal stem cells (BM-MSCs) and increased their cardiac protective effect. HPC dose-dependently increased the autophagy in BM-MSCs. However, the protective effects of HPC for 24 hours were the most pronounced. [Stem Cell Res Ther] Full Article Scientists used a mouse model to assess the effect of mesenchymal stem cells (MSCs) on the development of aneurysm rupture. They administered allogeneic bone marrow-derived MSCs or vehicle, six and nine days after aneurysm induction. MSC administration significantly reduced rupture rate. [Neurosurgery] Abstract The authors established endothelin-1 (EDN-1) overexpressed bone marrow-derived mesenchymal stem cells (BMSCs), proliferation ability and osteogenesis differentiation were detected respectively. Transduced BMSCs were then combined with CPC-scaffold to repair calvarial defects in rats to evaluate the in vivo osteogenic potential of EDN-1. EDN-1 overexpressed BMSCs showed increased proliferation and significantly increased osteogenesis potential ability than vector transfected control. [Exp Cell Res] Abstract Researchers investigated mesenchymal stem cells’ curative effects on methotrexate (MTX)-induced kidney and liver injuries. They found that MTX caused marked increase in malondialdehyde and nitrite/nitrate concentrations. [J Biochem Mol Toxicol] Abstract | |
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REVIEWSInvestigators discuss the possibility to achieve satisfactory regeneration of articular cartilage by means of human mesenchymal stem cells depleted of anti-chondrogenic factors and implanted in the site of injury. [Cell Mol Life Sci] Abstract The authors review the evidence for using bone marrow–derived mesenchymal stromal cells (BMSCs) to treat acute graft-versus-host disease and how this experience may inform the potential use of BMSCs as a treatment for inflammatory bowel diseases. [Cytotherapy] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSHitGen Ltd. announced a collaboration with the Scripps Research Institute and its affiliate, the Calibr. This collaboration is to discover and develop potential new therapies in areas of unmet clinical need, with an initial focus in oncology, regenerative medicine and virology. [The Scripps Research Institute] Press Release Cartiva, Inc. announced that it has completed enrollment and treatment of all 50 patients in a multi-center study evaluating the safety and effectiveness of Cartiva Synthetic Cartilage Implant for first carpometacarpal joint osteoarthritis at the base of the thumb. [Cartiva, Inc.] Press Release | |
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POLICY NEWSWhat Happened at March for Science Events around the World Tens of thousands of people gathered in Washington D.C., and at least 600 other cities around the world, in what may have been one of the largest-ever demonstrations in support of scientific research and evidence-based policymaking. [Nature News] Editorial French Scientists Focus on the Big Political Picture Researchers in France overwhelmingly oppose the far right and can stamp out its rise by turning out to register their disapproval. [Nature News] Editorial
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EVENTSNEW 18th International Congress of Developmental Biology Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Scientist – Stem Cell Biology (National Eye Institute) Part-Time Research Assistant – Mesenchymal Stem/Stromal Cell Research (NUI Galway) Postdoctoral Position – Craniofacial Molecular Biology (University of Southern California) Postdoctoral Researcher – Sequencing Analysis of Mesenchymal Tumors (University of Oxford) Postdoctoral Fellow – Cardiopulmonary Molecular Biology (Hannover Medical School) Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University) Postdoctoral Fellow – Tissue Engineering (University of California, Davis) Assistant/Associate Professors – Bone Biology (University of Michigan) Postdoctoral Fellow – Bone Biology and Bioinformatics (Stanford University) Postdoctoral Fellow – Bone Regeneration and Stem Cell Biology (New York University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mesenchymal Cell News Volume 9.16 | Apr 25 2017