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Pulmonary Cell News| Mesenchymal Cell News 9.17 May 1, 2017 | |
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TOP STORYScientists showed using genetic fate tracing in two murine models of bone marrow fibrosis (BMF) that Gli1+ mesenchymal stromal cells are recruited from the endosteal and perivascular niche to become fibrosis-driving myofibroblasts in the bone marrow. Genetic ablation of Gli1+ cells abolished BMF and rescued bone marrow failure. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROThe authors established a protocol for human skin mesenchymal stem cell (MSC) differentiation towards Schwann cell-like cells (SC-lcs) and to analyze the expression of sigma-1 receptor (S1R) in SC-lcs. Their data demonstrated that S1R plays an important role in skin MSC differentiation towards myelinating Schwann cells. [Mol Neurobiol] Abstract Scientists investigated the effect of interferon (IFN)-γ on the immunomodulatory capacity of a mesenchymal stem cell (MSC)/extracellular matrix complex (C-MSC) in vitro and to test the bone regenerative activity of C-MSC or IFN-γ-pretreated C-MSC (C-MSCγ) xenografts in a mice calvarial defect model. IFN-γ stimulated IDO expression in C-MSC. C-MSCγ, but not C-MSC, attenuated CD3/CD28-induced T cell proliferation and its suppressive effect was reversed by an IDO inhibitor. [Stem Cell Res Ther] Full Article The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation Researchers increased and decreased MAN1 expression in mesenchymal stem cells upon which standard osteogenic and adipogenic differentiation were performed. MAN1 knockdown increased osteogenesis and mineralization. They found that low levels of MAN1 facilitated the nuclear accumulation of regulatory smads and smads-related complexes, with a concurrently high expression of nuclear β-Catenin. [J Cell Biochem] Abstract Scientists systematically evaluated the effects of age on the quantity and quality of human adipose-derived stem cells (hADSCs) isolated from excised chest subcutaneous adipose tissue and investigated the underlying molecular mechanism. hADSCs were available from individuals across all age groups and maintained mesenchymal stem cell characteristics. However, the increased age of the donors was found to have a significant negative effect on the hADSC frequency base on CFU-Fs assay. [Cell Transplant] Full Article The authors investigated the effect of fibulin-1 (FBLN1) on the ability of human nasal inferior turbinate-derived mesenchymal stem cells (hTMSCs) to undergo osteogenic differentiation. FBLN1 significantly enhanced the adhesion activity and proliferation of hTMSCs. [J Biomed Mater Res A] Abstract IN VIVOThe authors evaluated the therapeutic efficacy and safety of mesenchymal stem cells (MSCs) for the treatment of patients with knee osteoarthritis (OA). They demonstrated that MSC treatment could significantly decrease visual analogue scale and increase International Knee Documentation Committee scoresafter a 24-month follow-up compared with controls. [PLoS One] Full Article PKH26 (red) dye-labeled adipose-derived (AD)-mesenchymal stem cells (MSC) or bone marrow-derived (BM-MSC) were administered intravenously to Lewis rat recipients of mismatched Brown Norway hindlimb transplants. AD-MSC and BM-MSC were associated with both overlapping and distinct dynamic networks and principal characteristics of inflammatory/immune mediators in vascularized composite allotransplantation grafts with short course tacrolimus induction therapy. [J Trauma Acute Care Surg] Abstract Scientists uncovered whether bone marrow mesenchymal stem cells (BMSCs) could repair cadmium-induced rat testis injury and explored the role of mitochondrial apoptosis in this process. Following two-week BMSCs-treatment, the therapy rats were heavier than the model rats, despite there being no difference in testicular cadmium contents between these groups, which were both significantly higher than the control group. BMSCs were observed in the testis of the therapy rats, in which pathological changes improved significantly compared with the model group. [Chem Biol Interact] Abstract | |
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REVIEWSThe Therapeutic Potential of Three-Dimensional Multipotent Mesenchymal Stromal Cell Spheroids The efficiency of clinical trials involving transplantation of multipotent mesenchymal stromal cells is often insufficient due to harsh conditions present within the target tissue including hypoxia, low nutrient supply as well as inflammatory reactions. This indicates the necessity for optimization of cell-based therapy approaches which might include either modification of the cell manufacturing process or specific cell pretreatment procedures prior to transplantation. [Stem Cell Res Ther] Full Article Researchers focus on in vitro potency assays proposed for characterization and release of different mesenchymal stromal cell medicinal products. They discuss the most used functional assays, as presented in scientific advices and literature, highlighting specific advantages and limitations of the various assays. [Cytotherapy] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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SCIENCE NEWSBrainStorm to Present at Two Scientific Conferences in May BrainStorm Cell Therapeutics Inc. announced that the company will present data from its Phase II clinical study of NurOwn® in amyotrophic lateral sclerosis. [Press release from BrainStorm Cell Therapeutics Inc. discussing research to be presented at the International Society for Cellular Therapy (ISCT) Annual Conference in London, England, and the World Advanced Therapy and Regenerative Medicine Congress, London] Press Release | |
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INDUSTRY NEWSSpinalCyte, LLC Receives New Australian Patent SpinalCyte, LLC announced the issuance of the Australian Patent “Generation of Cartilage Ex Vivo from Fibroblasts.” The technology described in the patent involves using mechanical stress in an ex vivo, low oxygen environment under certain conditions to produce chondrocytes to regrow cartilage. [SpinalCyte, LLC.] Press Release Aspen Institute Now Offering Regenerative STEM Cell Therapy Aspen Institute has added umbilical cord blood STEM Cells to its treatment regimen focused on anti-aging and orthopedic regenerative medicine. [Aspen Institute for Anti-Aging & Regenerative Medicine (EIN Presswire)] Press Release | |
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POLICY NEWSResearchers Frustrated by Italian Misconduct Probe More than five years ago, Italian police began investigating allegations of research misconduct in papers by Alfredo Fusco, a prominent cancer scientist in Naples. Researchers frustrated by the case’s slow progress have told Nature that there is strong evidence that dozens of papers may contain manipulated data — and that a commercial photography studio was called in to cut and paste images. They say they are speaking out about the magnitude of the allegations because of their increasing impatience with the slow pace of investigations by police and by academic authorities. [Nature News] Editorial How Science Fares in the U.S. Budget Deal Congress has finally reached a deal on spending bills for the 2017 fiscal year. House of Representatives and Senate leaders announced that they expect lawmakers to vote on an agreement that wraps together all 12 appropriations bills that fund federal operations. For the past seven months, the government has been operating under a continuing resolution that froze 2017 spending at most agencies at 2016 levels and generally prevented them from starting new programs. [ScienceInsider] Editorial Controversial UK Research Reform Crosses Finish Line A controversial and wide-ranging shake-up of the United Kingdom’s (UK’s) research and higher-education landscape has been completed, amid a huge rush by the country’s parliament to push through legislation. [Nature News] Editorial $10 Million Settlement over Alleged Misconduct in Boston Heart Stem Cell Lab A research misconduct investigation of a prominent stem cell lab by the Harvard University-affiliated Brigham and Women’s Hospital in Boston has led to a massive settlement with the U.S. government over allegations of fraudulently obtained federal grants. [ScienceInsider] Editorial
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EVENTSNEW EACR-AACR-SIC Special Conference 2017: The Challenges of Optimizing Immuno- and Targeted Therapies: From Cancer Biology to the Clinic Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Position – Stem Cells and Tissue Engineering (Queensland University of Technology) NEW Postdoctoral Position – Mesenchymal Stem Cell Biology (Longboats Explorers Inc.) Part-Time Research Assistant – Mesenchymal Stem/Stromal Cell Research (NUI Galway) Postdoctoral Position – Craniofacial Molecular Biology (University of Southern California) Postdoctoral Researcher – Sequencing Analysis of Mesenchymal Tumors (University of Oxford) Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University) Postdoctoral Fellow – Tissue Engineering (University of California, Davis) Assistant/Associate Professors – Bone Biology (University of Michigan) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mesenchymal Cell News Volume 9.17 | May 2 2017
