Mesenchymal Cell News Volume 9.28 | Jul 18 2017

TOP STORY

Mesenchymal Stromal Cell-Derived IL-6 Promotes Epithelial-Mesenchymal Transition and Acquisition of Epithelial Stem-Like Cell Properties in Ameloblastoma Epithelial Cells

To explore the stromal effect on tumor pathogenesis, researchers isolated and characterized both mesenchymal stromal (AM-MSCs) and epithelial cells (AM-EpiCs) from follicular ameloblastoma and demonstrated that, in in vitro culture, AM-MSCs secreted a significantly higher level of IL-6 as compared to the counterpart AM-EpiCs. [Stem Cells] Abstract

(Ranked by impact factor of the journal)

IN VITRO

Pleiotropic Effects of Sphingosine-1-Phosphate Signaling to Control Human Chorionic Mesenchymal Stem Cell Physiology

The authors revealed the presence of multiple sphingosine-1-phosphate receptor isoforms in chorion-derived MSCs. [Cell Death Dis] Full Article

Human Platelet Lysate versus Fetal Calf Serum: These Supplements Do Not Select for Different Mesenchymal Stromal Cells

Scientists isolated and expanded human bone marrow-derived MSCs in parallel with human platelet lysate (HPL) or fetal calf serum and demonstrated that HPL significantly increases proliferation and leads to dramatic differences in cellular morphology. [Sci Rep] Full Article

Mesenchymal Stem/Multipotent Stromal Cells from Human Decidua Basalis Reduce Endothelial Cell Activation

Investigators examined the ability of MSCs from the decidua basalis of human placenta to protect endothelial cells from activation through monocyte adhesion, by modulating endothelial proliferation, migration, adhesion and inflammatory marker expression. [Stem Cells Dev] Abstract

Bone Marrow-Derived Mesenchymal Stem Cells Propagate Immunosuppressive/Anti-Inflammatory Macrophages in Cell-to-Cell Contact-Independent and -Dependent Manners under Hypoxic Culture

Scientists demonstrated that bone marrow-derived lineage-positive blood cells proliferated and differentiated into M2-macrophages by cooperation with the bone marrow-derived MSCs under hypoxic conditions. [Exp Cell Res] Abstract

Flow Velocity-Driven Differentiation of Human Mesenchymal Stromal Cells in Silk Fibroin Scaffolds: A Combined Experimental and Computational Approach

The authors demonstrated the feasibility to drive cell behavior of human mesenchymal stromal cells by the flow velocity applied in agreement with mechanical loading mimicking early fracture healing or bone remodeling. [PLoS One] Full Article

IN VIVO

TSG-6 Secreted by Human Adipose Tissue-Derived Mesenchymal Stem Cells Ameliorates DSS-Induced Colitis by Inducing M2 Macrophage Polarization in Mice

Researchers investigated the therapeutic effects of human adipose tissue-derived-MSCs in an inflammatory bowel disease mouse model and explored the mechanisms of the regulation of inflammation. [Sci Rep] Full Article

Stromal Derived Factor-1 Mediates the Lung Regenerative Effects of Mesenchymal Stem Cells in a Rodent Model of Bronchopulmonary Dysplasia

The authors tested the hypothesis that stromal derived factor-1 mediates MSC protective effects in experimental bronchopulmonary dysplasia by modulating angiogenesis. [Respir Res] Full Article

Pericytes Extend Survival of ALS SOD1 Mice and Induce the Expression of Antioxidant Enzymes in the Murine Model and in iPSCs Derived Neuronal Cells from an ALS Patient

Pericytes and MSCs were derived from the same adipose tissue sample and were administered to SOD1 mice intraperitoneally. The effects of the two treatments were compared. [Stem Cell Rev] Full Article | Graphical Abstract

Mesenchymal Stem Cell Transplantation Carried in SVVYGLR Modified Self-Assembling Peptide Promoted Cardiac Repair and Angiogenesis after Myocardial Infarction

Investigators designed a new self-assembling peptide through adding angiogenic polypeptide SVVYGLR to the carboxyl terminal of RADA16, and evaluated the therapeutic potential of MSC transplantation carried in this designer self-assembling peptide on myocardial infarction. [Biochem Biophys Res Commun] Abstract

Concise Review: The Deleterious Effects of Cigarette Smoking and Nicotine Usage and Mesenchymal Stem Cell Function and Implications for Cell-Based Therapies

The authors provide a brief introduction into MSCs and their respective niches and a summary regarding the interactions of cigarettes and nicotine with MSCs populations. Specifically, the effects of cigarette smoke and nicotine on the regenerative potential of MSCs are covered with an emphasis on considerations for the development of future cell based clinical trials and therapies. [Stem Cells Transl Med] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

MAX BioPharma Announces Key Update to its Oxysterol Therapeutics^® Development Program

MAX BioPharma, Inc. announced that it has obtained promising positive results from its Proof of Concept study using one of its therapeutic candidates for intervention in osteoporosis. [MAX BioPharma, Inc. (PR Newswire Association LLC.)] Press Release

Korea Approves the World’s First Cell and Gene Therapy for Knee Osteoarthritis

TissueGene, Inc. announced that Kolon Life Science has received marketing approval for Invossa-K Inj., the world’s first cell and gene therapy for degenerative arthritis from the Korea Ministry of Food and Drug Safety. [TissueGene, Inc.] Press Release

ISSCR Opposes U.S. Ban on Federal Funding for Fetal Tissue Research

The ISSCR opposes a provision of the U.S. House of Representatives Labor-HHS-Education FY18 Appropriations bill that would ban federal funding for fetal tissue research. If enacted, this legislation would severely impede research that is necessary for the development of new treatments for a wide range of serious and incurable diseases. It would have a devastating effect on the future of biomedical advances and regenerative medicine. [International Society for Stem Cell Research] Editorial

Johnson Calls on House to Include Right to Try in FDA Reauthorization Bill

Sen. Ron Johnson (R-Wis.) released a statement calling on House leadership to include right to try language in the House FDA Reauthorization bill. [U.S. Senate Committee on Homeland Security and Governmental Affairs] Press Release

Relatively Few NIH Grantees Get Lion’s Share of Agency’s Funding

The rich have been getting richer in the biomedical research enterprise, and the system favors those who are already doing pretty well, according to a new analysis of National Institutes of Health (NIH) grant recipients. [ScienceInsider] Editorial

NEW ICSCB 2018: 20^th International Conference on Stem Cell Biology
March 12-13, 2018
Miami, Florida, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher(s) – Therapeutic Potential of Mesenchymal Stem Cells in Sepsis (NUI Galway)

NEW Assistant/Associate Professor – Pharmacology & Pharmaceutical Sciences (University of Southern California)

NEW Postdoctoral Position – Cell Biology (The Scripps Research Institute)

Postdoctoral Fellow – Regenerative Medicine (Loma Linda University)

PhD Student Position – Skeletal Cell Biology (KU Leuven)

Postdoctoral Position – Metabolism (University of North Carolina, Chapel Hill)

Postdoctoral Researcher – Vascular-Stromal Regulation (Weill Cornell Medical College)

Postdoctoral Position – Gene Regulation in Stem Cells and Tissue Regeneration (Northwestern University)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

PhD Position – Stem Cells and Tissue Engineering (Queensland University of Technology)

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