Mesenchymal Cell News Volume 9.29 | Jul 25 2017

TOP STORY

Limbal Stromal Cells Derived from Porcine Tissue Demonstrate Mesenchymal Characteristics In Vitro

Limbal stromal cells from the human ocular surface display MSC characteristics in vitro. Researchers isolated cells from the porcine limbal stroma, characterized them, and evaluated their ability to support angiogenesis and the culture of porcine limbal epithelial stem cells. [Sci Rep] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Hepatic Perivascular Mesenchymal Stem Cells with Myogenic Properties

Pericytes are multipotent MSCs located on the walls of blood vessels in various organs and are characterized as CD146⁺ cells. Scientists immunohistochemically detected such pericytes in the perivascular regions of liver from two mouse genotypes, namely wild-type and myostatin null. [J Tissue Eng Regen Med] Abstract

Role of the Protease Corin in Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

Investigators isolated and cultured human bone marrow-derived MSCs that were capable of undergoing chondrogenic, osteogenic and adipogenic lineage differentiation. By RT-PCR and immunostaining, they found that corin expression was up-regulated when these MSCs underwent chondrogenic, osteogenic and adipogenic differentiation. [J Tissue Eng Regen Med] Abstract

Human Menstrual Blood-Derived Mesenchymal Stem Cells as Potential Cell Carriers for Oncolytic Adenovirus

The authors indicated that menstrual blood-derived MSCs can be isolated without invasive methods, they have an increased proliferation rate compared to bone marrow-MSCs, and they can be efficiently infected with different serotype 5-based capsid-modified adenoviruses, leading to viral replication and release. [Stem Cells Int] Full Article

Megakaryocytes Enhance Mesenchymal Stromal Cells Proliferation and Inhibit Differentiation

Researchers examined MSC proliferation and osteoblastic differentiation when rabbit or mouse megakaryocytes were cultured with rabbit bone marrow stromal cells, rabbit dental pulp stromal cells, or mouse bone marrow stromal cells. [J Cell Biochem] Abstract

Genetically Engineered Suicide Gene in Mesenchymal Stem Cells Using a Tet-On System for Anaplastic Thyroid Cancer

Scientists designed the Tet-On system using a retroviral vector expressing herpes simplex virus thymidine kinase with dual reporters. Mouse bone marrow-derived MSCs were transduced using this system with or without the Tet-On system. [PLoS One] Full Article

Glycinol Enhances Osteogenic Differentiation and Attenuates the Effects of Age on Mesenchymal Stem Cells

The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older and younger subjects. BMSCs isolated from older donors demonstrated reduced osteogenesis. [Regen Med] Abstract

Migration Ability and Toll-Like Receptor Expression of Human Mesenchymal Stem Cells Improves Significantly after Three-Dimensional Culture

The authors seeded human umbilical cord-derived MSCs (hUCMSCs) in a 3D culture system with porcine acellular dermal matrix, and investigated the phenotypic changes, the expression changes of some important receptors, including Toll-like receptors and C-X-C chemokine receptor type 4 when hUCMSCs were transferred from 2D to 3D systems, as well as the alterations in in vivo homing and migration potential. [Biochem Biophys Res Commun] Abstract

IN VIVO

In Vivo Imaging to Monitor Differentiation and Therapeutic Effects of Transplanted Mesenchymal Stem Cells in Myocardial Infarction

Investigators used a noninvasive multimodality imaging approach to monitor differentiation of transplanted bone marrow MSCs and recovery of cardiac function in an in vivo model of myocardial infarction. [Sci Rep] Full Article

Interleukin-3 Enhances the Migration of Human Mesenchymal Stem Cells by Regulating Expression of CXCR4

Scientists investigated the role of interleukin-3 (IL-3) in migration of human MSCs under both in vitro and in vivo conditions. The in vivo migration of IL-3-preconditioned MSCs was investigated using a subcutaneous matrigel-releasing stromal cell-derived factor-1 alpha model in immunocompromized mice. [Stem Cell Res Ther] Full Article

Mesenchymal Stem Cell-Derived Factors: Immuno-Modulatory Effects and Therapeutic Potential

Investigators emphasize current findings regarding immuno-modulatory effects of MSC-derived factors and emphasize their potential in the therapy of immune-mediated diseases. [Biofactors] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Brainstorm Awarded $16 Million Non-Dilutive Grant from CIRM in Support of Phase III Clinical Trial of NurOwn^® in ALS

Brainstorm Cell Therapeutics Inc. announced that the California Institute for Regenerative Medicine (CIRM) has awarded Brainstorm a grant of $16 million to support the pivotal Phase III study of NurOwn^®, for the treatment of amyotrophic lateral sclerosis (ALS). [Brainstorm Cell Therapeutics Inc.] Press Release

BrainStorm Announces Agreements with Mass. General Hospital and California Pacific Medical Center to Participate in Phase III Trial of NurOwn^® in ALS

BrainStorm Cell Therapeutics Inc. announced that it has signed definitive agreements with Massachusetts General Hospital and California Pacific Medical Center to enroll patients in the planned Phase III clinical trial of NurOwn^® in amyotrophic lateral sclerosis (ALS), pending FDA and Institutional Review Board approvals. [BrainStorm Cell Therapeutics Inc.] Press Release

French Funding Agency President Resigns amidst Tensions

Michael Matlosz, president and CEO of the French National Research Agency in Paris, resigned following months of controversy over how the agency handles grant proposal evaluations. [ScienceInsider] Editorial

US Defence Agencies Grapple with Gene Drives

The JASONs, a group of elite scientists that advises the US government on national security, has weighed in on issues ranging from cyber security to renewing America’s nuclear arsenal. But at a meeting in June, the secretive group took stock of a new threat: gene drives, a genetic-engineering technology that can swiftly spread modifications through entire populations and could help vanquish malaria-spreading mosquitoes. [Nature News] Editorial

NEW EuroSciCon Stem Cell 2018
April 16-17, 2018
Amsterdam, Netherlands

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Oral Biology (Rutgers School of Dental Medicine)

NEW Researcher – Adipose-Derived Stem Cells for the Therapy of Chronic Cutaneous Ulcers (Università degli Studi di Parma)

Postdoctoral Researcher(s) – Therapeutic Potential of Mesenchymal Stem Cells in Sepsis (NUI Galway)

Assistant/Associate Professor – Pharmacology & Pharmaceutical Sciences (University of Southern California)

NEW Postdoctoral Position – Cell Biology (The Scripps Research Institute)

Postdoctoral Fellow – Regenerative Medicine (Loma Linda University)

Postdoctoral Position – Metabolism (University of North Carolina, Chapel Hill)

Postdoctoral Researcher – Vascular-Stromal Regulation (Weill Cornell Medical College)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

PhD Position – Stem Cells and Tissue Engineering (Queensland University of Technology)

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