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Pulmonary Cell News| Mesenchymal Cell News 9.30 August 1, 2017 | |
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TOP STORYMechanoresponsive Stem Cells to Target Cancer Metastases through Biophysical Cues Researchers present a mechanoresponsive cell system (MRCS) to selectively identify and treat cancer metastases by targeting the specific biophysical cues in the tumor niche in vivo. The MRCS uses mechanosensitive promoter–driven MSC–based vectors, which selectively home to and target cancer metastases in response to specific mechanical cues to deliver therapeutics to effectively kill cancer cells. [Sci Transl Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROShift of EMT Gradient in 3D Spheroid MSCs for Activation of Mesenchymal Niche Function Scientists showed that MSCs in 3D spheroids undergo progression towards the epithelial-mesenchymal transition (EMT), driven by upregulation of EMT-promoting microRNAs and suppression of EMT-inhibitory miRNAs. [Sci Rep] Full Article When human articular chondrocytes and human MSCs were inoculated at 20,000 cells/mL into 125 mL suspension bioreactors and fed weekly, they spontaneously formed 3D aggregates and proliferated, resulting in a 4.75-fold increase over 16 days. [J Tissue Eng Regen Med] Abstract The authors investigated the signaling pathway that minocycline modulates in MSCs which results in their enhanced wound healing phenotype and determined whether preconditioning MSCs with minocycline has an effect on antimicrobial activity. [Stem Cell Res Ther] Full Article Scientists found that pro-inflammatory cytokines have a strong impact on the secretome of human bone marrow-derived MSCs and that the large majority of cytokine-induced proteins are involved in inflammation and/or angiogenesis. [J Proteomics] Abstract | Graphical Abstract To study the proliferative and differentiation potential of MSCs isolated from bone marrow of sternum, the authors made a comparative analysis between samples of patients with ischemic or non-ischemic valvular heart diseases. [J Transl Med] Full Article IN VIVOInvestigators tested the efficacy of Good Manufacturing Practices compliant human bone marrow-MSCs, injected intravenously 3.5 hours after injury in mice subjected to transient middle cerebral artery occlusion. [Sci Rep] Full Article Mesenchymal Stem Cells with IGF-1 and TGF- β1 in Laminin Gel for Osteochondral Defects in Rabbits Researchers evaluated allogenic bone marrow MSCs alone or in combination with growth factors, insulin-like growth factor-1 (IGF-1) and transforming growth factor-β1 (TGF-β1) in laminin scaffolds for healing of osteochondral defects. [Biomed Pharmacother] Abstract The authors evaluated the potential of MSC derived from the amniotic fluid, an interesting MSC source for cell therapeutic applications in the perinatal period, for immune modulation when added to a biomaterial. [Hernia] Abstract | |
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REVIEWSThe authors focus on MSCs and their extracellular vesicles as active pharmaceutical/principle ingredients, as well as drug delivery systems, considering their ability to reach inflamed and damaged tissues and to prolong the release of encapsulated drugs. [J Control Release] Abstract | Graphical Abstract Scientists outline the biology of stem/progenitor cells derived from the articular cartilage, the synovial membrane, and the synovial fluid, including their tissue distribution, function and biological characteristics. [Stem Cell Rev] Abstract Therapeutic Potential of Mesenchymal Stem Cells for Diabetes The authors summarize the role of mesenchymal stem cells (MSCs) on tissue repair, provide emerging strategies to improve MSC function, and describe how these processes translate to clinical treatments for diabetes. [J Mol Endocrinol] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSStimLabs Enters Regenerative Medicine Market with Two Groundbreaking Amniotic Tissue Products StimLabs announced two products in regenerative medicine. Revita®, the first full thickness placental membrane allograft in a shelf-stable format, and Ascent™, an amniotic fluid allograft that captures key amniotic fluid components in a shelf-stable powder. [StimLabs (PR Newswire Association LLC.)] Press Release Gamida Cell Announces $3.5 Million Grant from the Israeli Government Gamida Cell announced that it has been awarded a grant of $3.5 million from the Israel Innovation Authority of the Israeli Ministry of Economy and Industry. [Gamida Cell] Press Release | |
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POLICY NEWSUniversity of Tokyo Probe Says Chromosome Team Doctored Images After a nearly year-long investigation into anonymous allegations of data and image falsification in numerous papers, a University of Tokyo committee announced it had confirmed that one research group falsified images and graphs in five papers. The panel cleared five other research groups of wrongdoing. [ScienceInsider] Editorial Why Would a University Pay a Scientist Found Guilty of Misconduct to Leave? In June 2016, investigators at the University of Georgia in Athens concluded that Azza El-Remessy, a faculty member who studied the impact of diabetes on the eye, had committed misconduct and recommended she be terminated. El-Remessy hired a lawyer to dispute the findings, but the following October she gave up her challenge after the university paid her $100,000—essentially to leave. [ScienceInsider] Editorial China Cracks Down after Investigation Finds Massive Peer-Review Fraud A massive peer-review fraud has triggered a tough response from the Chinese government. Officials last week announced that more than 400 researchers listed as authors on some 100 now-retracted papers will face disciplinary action because their misconduct has seriously damaged China’s scientific reputation. [ScienceInsider] Editorial At Harvard, Extraordinary Court Battle between Ph.D. Student and Prominent Researcher Grinds On The conflict between Gustavo German, a Harvard doctoral student in biomedicine, and Lee Rubin, a prominent stem cell researcher, has continued to evolve. Amid continued legal jousting, the situation has remained difficult for all of the parties involved in this tumultuous episode. [ScienceInsider] Editorial
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EVENTSNEW 5th Annual European Congress on Clinical & Translational Sciences (EUSTM-2017) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Assistant Professor – Human Anatomy and Cell Science (University Of Manitoba) Postdoctoral Fellow – Oral Biology (Rutgers School of Dental Medicine) Postdoctoral Position – Cell Biology (The Scripps Research Institute) Postdoctoral Fellow – Regenerative Medicine (Loma Linda University) Postdoctoral Position – Metabolism (University of North Carolina, Chapel Hill) Postdoctoral Researcher – Vascular-Stromal Regulation (Weill Cornell Medical College) PhD Position – Stem Cells and Tissue Engineering (Queensland University of Technology) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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