Mesenchymal Cell News Volume 9.31 | Aug 8 2017

TOP STORY

Therapeutic Effect of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Experimental Corneal Failure Due to Limbal Stem Cell Niche Damage

Investigators tested the tolerance and the efficacy of human adipose tissue-derived MSCs to regenerate the ocular surface in two experimental models of limbal stem cell deficiency that closely resemble the different severity grades of the human pathology. [Stem Cells] Abstract

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IN VITRO

Histone Deacetylase 3 Deletion in Mesenchymal Progenitor Cells Hinders Long Bone Development

The functions of histone deacetylase (Hdac) 3, one of the enzymes blocked by current Hdac inhibitor therapies, in skeletal mesenchymal progenitor cells were determined. [J Bone Miner Res] Abstract

Oleanolic Acid Enhances Mesenchymal Stromal Cell Osteogenic Potential by Inhibition of Notch Signaling

Scientists examined effects of oleanolic acid (OA) on cell viability, osteogenic differentiation in MSCs, and the involvement of Notch and BMP signaling. OA induced bone marrow derived MSC differentiation towards osteoprogenitor cells and inhibited Notch signaling in a dose dependent manner. [Sci Rep] Full Article

Mesenchymal Stem Cells Derived from Inflamed Dental Pulpal and Gingival Tissue: A Potential Application for Bone Formation

Investigators verified the ability of dental pulp MSCs and gingival MSCs harvested from periodontally affected teeth to produce new mineralized bone tissue in vitro, and compared this to cells from healthy teeth. [Stem Cell Res Ther] Full Article

Inhibition of Human Mesenchymal Stem Cell Proliferation via Wnt Signaling Activation

The authors observed that activation of endogenous canonical Wnt signaling with LiCl, which decreased β-catenin phosphorylation, leads to a decrease in hMSC proliferation. [J Cell Biochem] Abstract

In Situ Forming Gelatin Hydrogels-Directed Angiogenic Differentiation and Activity of Patient-Derived Human Mesenchymal Stem Cells

Scientists report in situ cross-linkable gelatin−hydroxyphenyl propionic acid hydrogels that can induce pro-angiogenic profiles of MSCs via purely material-driven effects. [Int J Mol Sci] Full Article

IN VIVO

Liposome-Indocyanine Green Nanoprobes for Optical Labeling and Tracking of Human Mesenchymal Stem Cells Post-Transplantation In Vivo

Labeled human MSC recapitulating a 3D cellular environment were transplanted as spheroids subcutaneously and intracranially in athymic nude mice. Cells emitted a strong NIR signal used for tracking post-transplantation with the IVIS imaging system up to two weeks and one week. [Adv Healthc Mater] Abstract

Co-Injection of Mesenchymal Stem Cells with Endothelial Progenitor Cells Accelerates Muscle Recovery in Hind Limb Ischemia through an Endoglin-Dependent Mechanism

Researchers examined whether co-administration of endothelial colony-forming cells (ECFCs) and MSCs bolsters vasculogenic activity in nude mice with hind limb ischemia. In addition, as they have previously shown that endoglin is a key adhesion molecule, they evaluated its involvement in ECFC/MSC interaction. [Thromb Haemost] Abstract

Human Adipose-Derived Mesenchymal Stem Cells Seeded into a Collagen-Hydroxyapatite Scaffold Promote Bone Augmentation after Implantation in the Mouse

In order to evaluate the regenerative potential of human adipose-derived stem cells along with an osteoinductive biomaterial, researchers used collagen/hydroxyapatite scaffolds to test ectopic bone formation after subcutaneous implantation in mice. [Sci Rep] Full Article

Mesenchymal Stem Cells in Fibrotic Disease

The authors give an overview of the emerging role of MSCs and MSC-like cells in myofibroblast-mediated fibrotic disease in the kidney, lung, heart, liver, skin, and bone marrow. [Cell Stem Cell] Abstract

Mesenchymal Stem Cell Differentiation: Control by Calcium-Activated Potassium Channels

Scientists evaluated the contribution of calcium-activated potassium channels to the three main components of MSC differentiation: initiation, proliferation and migration. They demonstrated the importance of the membrane potential and the apparent association of hyperpolarization with differentiation. [J Cell Physiol] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

MiMedx Files with the FDA to Initiate Its Investigational New Drug Achilles Tendonitis Phase III Clinical Trial

MiMedx Group, Inc. announced that the company has filed with the FDA to initiate its Investigational New Drug Phase III Achilles Tendonitis clinical study. [MiMedx Group, Inc.] Press Release

Ampio Announces the Allowance of a Composition and Methods Patent in the USA Using Ampion™ in Conjunction with Stem Cells

Ampio Pharmaceuticals, Inc. announced the allowance of an important composition and methods patent in the USA complimenting a series of patents on Ampion™. The patent is entitled: ”Compositions for the Mobilization, Homing, Expansion, and Differentiation of Stem Cells and Methods of Using the Same.” [Ampio Pharmaceuticals, Inc.] Press Release

FDA Cracks Down on Pioneering Doctor Who Created a Three-Parent Baby

The New York-based doctor who helped a couple have a child using DNA from three people has been told by the FDA that he can’t go ahead with clinical trials meant to test the technique. [MIT Technology Review] Editorial

CRISPR Patent Battle in Europe Takes a ‘Wild’ Twist with Surprising Player

MilliporeSigma, a subsidiary of pharmaceutical giant Merck KGaA of Darmstadt, Germany, has become a new major player in the complicated European patent battles over CRISPR, the revolutionary genome-editing tool. [ScienceInsider] Editorial

Discredited Gene-Editing Researcher Vows to Clear His Name

A Chinese biologist whose team retracted a high-profile paper on a gene-editing technology has vowed to press ahead with experiments that he hopes will vindicate the potential rival to the CRISPR/Cas9 system. [ScienceInsider] Editorial

Drug Approval Needs a Helping Hand

It’s time for researchers to lend their expertise to expediting the arrival of cutting-edge therapies that are waiting in the wings. [Nature News] Editorial

NEW Translational Stem Cell Research Conference
October 24-25, 2017
New York, New York, United States

Visit our events page to see a complete list of events in the community.

NEW Research Associate – Cellular and Molecular Medicine (University of Bristol)

Postdoctoral Position – Epigenetic Control of Stem Cell Function and Metabolism (University of Freiburg)

Assistant Professor – Human Anatomy and Cell Science (University Of Manitoba)

Postdoctoral Fellow – Oral Biology (Rutgers School of Dental Medicine)

Researcher – Adipose-Derived Stem Cells for the Therapy of Chronic Cutaneous Ulcers (Università degli Studi di Parma)

Assistant/Associate Professor – Pharmacology & Pharmaceutical Sciences (University of Southern California)

Postdoctoral Position – Cell Biology (The Scripps Research Institute)

Postdoctoral Fellow – Regenerative Medicine (Loma Linda University)

Postdoctoral Researcher – Vascular-Stromal Regulation (Weill Cornell Medical College)

PhD Position – Stem Cells and Tissue Engineering (Queensland University of Technology)

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