Mesenchymal Cell News Volume 9.34 | Aug 29 2017

TOP STORY

Self-Assembled N-Cadherin Mimetic Peptide Hydrogels Promote the Chondrogenesis of Mesenchymal Stem Cells through Inhibition of Canonical Wnt/β-Catenin Signaling

Encapsulation of human MSCs in self-assembled N-cadherin mimetic peptide hydrogels showed enhanced expression of chondrogenic marker genes and deposition of cartilage specific extracellular matrix rich in proteoglycan and type II collagen compared to control hydrogels, with a scrambled-sequence peptide after 14 days of chondrogenic culture. [Biomaterials] Abstract

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IN VITRO

Methylome Analysis of Human Bone Marrow MSCs Reveals Extensive Age- and Culture-Induced Changes at Distal Regulatory Elements

Scientists revealed that the breadth of DNA methylation dynamics associated with aging and expansion is greater than previously reported. Methylation changes are enriched at known distal transcription factor binding sites such as enhancer elements, instead of CpG-rich regions, and are associated with changes in gene expression. [Stem Cell Reports] Full Article | Graphical Abstract

Doxorubicin Upregulates CXCR4 via miR-200c/ZEB1-Dependent Mechanism in Human Cardiac Mesenchymal Progenitor Cells

Investigators showed that in a mouse model of doxorubicin (DOXO)-induced cardiomyopathy, C-X-C chemokine receptor type 4 (CXCR4)⁺ cells were increased in response to DOXO, mainly in human cardiac mesenchymal progenitor cells, a subpopulation with regenerative potential. [Cell Death Dis] Full Article

Quantitative Proteomic Characterization of Lung-MSC and Bone Marrow-MSC Using DIA-Mass Spectrometry

The authors present an in-depth mass spectrometry based strategy to investigate the proteomes of lung-MSC and bone marrow-MSC. [Sci Rep] Full Article

Homogeneity Evaluation of Mesenchymal Stem Cells Based on Electrotaxis Analysis

Researchers suggest an electrotaxis analysis as a new method to evaluate the homogeneity of mesenchymal stem cells which can observe the stem cell population in culture condition and wide use to various types of stem cells. [Sci Rep] Full Article

Microgrooved-Surface Topography Enhances Cellular Division and Proliferation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells

Investigators cultured mouse bone marrow-derived MSCs on microgrooved bearing surface, partially mimicking in vivo reticulated niche, to study its effect on morphology, pluripotency factor-associated stemness, cell division and rate of proliferation. [PLoS One] Full Article

Carvacrol Promotes Angiogenic Paracrine Potential and Endothelial Differentiation of Human Mesenchymal Stem Cells at Low Concentrations

Carvacrol was able to increase mesenchymal stem cell survival and migration rate. An increased activity of SOD was obtained while GPx activity unchanged or reduced. Scientists confirmed the endothelial differentiation of stem cells by detecting vWF and VE-cadherin expression. [Microvasc Res] Abstract

IN VIVO

Peptide Modified Mesenchymal Stem Cells as Targeting Delivery System Transfected with miR-133b for the Treatment of Cerebral Ischemia

A peptide-based targeting approach was established to enhance cell homing to cerebral ischemic lesion. Palmitic acid–peptide painted onto the cell membrane was able to direct MSCs to ischemic tissues without any observed cell cytotoxicity and influence on differentiation, thus reducing accumulation of cells in peripheral organs and increasing engraftment of cells in the targeted tissues. [Int J Pharm] Abstract

Mesenchymal Stem Cells Correct Impaired Diabetic Wound Healing by Decreasing ECM Proteolysis

Investigators demonstrated that collagen I and III protein content is significantly reduced in diabetic wounds, and treatment with MSCs significantly improved collagen I content in both non-diabetic and diabetic wounds. [Physiol Genomics] Abstract

In Vivo Immunological Properties Research on Mesenchymal Stem Cells Based Engineering Cartilage by a Dialyzer Pocket Model

Based on a dialyzer pocket model, changes in immunological properties and the differentiation of seeded MSCs in collagen hydrogel were studied in muscle and articular cavity implantation, respectively. [J Mater Sci Mater Med] Abstract

Targeted Antitumor Therapy Mediated by Prodrug-Activating Mesenchymal Stromal Cells

The authors summarize major determinants to be considered for the application of the prodrug-activating MSCs in antitumor therapy in order to maximize therapeutic efficiency. [Cancer Lett] Abstract

Mesenchymal Stem Cells in Cardiovascular Regeneration: Emerging Research Directions and Clinical Applications

Researchers summarize information about the most important features of MSCs and recent discoveries in the field of MSCs research, and describe current data from preclinical and early clinical studies on the use of MSCs in cardiovascular regeneration. [Stem Cells Transl Med] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Positive Data from Cynata MSCs in Second Preclinical Asthma Study

Cynata Therapeutics Limited announced further highly promising data supporting the efficacy of its proprietary Cymerus™ MSCs in a second preclinical asthma study. [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] Press Release

Symic Bio Enrolls First Patient in MODIFY2 Phase II Trial of SB-061 for the Treatment of Osteoarthritis

Symic Bio announced the treatment of the first patient in the MODIFY2 Phase II clinical trial investigating SB-061 for pain management in mild-to-moderate osteoarthritis of the knee. [Symic Bio] Press Release

Statement from FDA Commissioner Scott Gottlieb, M.D. on the FDA’s New Policy Steps and Enforcement Efforts to Ensure Proper Oversight of Stem Cell Therapies and Regenerative Medicine

In the last few days alone, the FDA has taken steps in Florida and California to address a number of especially troubling products being marketed. But unfortunately, these are examples of a larger pool of actors who claim that their unproven and unsafe products will address a serious disease, but instead put patients at significant risk. [U.S. Food and Drug Administration] Editorial

FDA Warns US Stem Cell Clinic of Significant Deviations

The FDA posted a warning letter issued to US Stem Cell Clinic of Sunrise, Florida, and its Chief Scientific Officer Kristin Comella for marketing stem cell products without FDA approval and for significant deviations from current good manufacturing practice requirements, including some that could impact the sterility of their products, putting patients at risk. [U.S. Food and Drug Administration] Editorial

NEW Stem Cell Society Singapore (SCSS) Symposium 2017
November 16-17, 2017
Singapore, Singapore

Visit our events page to see a complete list of events in the community.

NEW Researcher – Skeletal Tissue Engineering (KU Leuven)

Assistant Professor – Cell, Developmental, and Regenerative Biology (Icahn School of Medicine at Mount Sinai)

Faculty Position – Regenerative Biology (Northwestern University)

Professor – Bioengineering (University of Pittsburgh)

Assistant Professor – Stem Cell and Regenerative Biology (Harvard University)

Postdoctoral Position – Epigenetic Control of Stem Cell Function and Metabolism (University of Freiburg)

Assistant Professor – Human Anatomy and Cell Science (University Of Manitoba)

Postdoctoral Fellow – Oral Biology (Rutgers School of Dental Medicine)

Assistant/Associate Professor – Pharmacology & Pharmaceutical Sciences (University of Southern California)

Postdoctoral Position – Cell Biology (The Scripps Research Institute)

Postdoctoral Fellow – Regenerative Medicine (Loma Linda University)

PhD Position – Stem Cells and Tissue Engineering (Queensland University of Technology)

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