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Pulmonary Cell News| Mesenchymal Cell News 9.37 September 19, 2017 | |
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TOP STORYAdipose-derived stem cells (hADSCs), a kind of promising stem cell for autologous stem cell tissue engineering, were used as stem cell model. Researchers proved that hydroxyapatite morphology can determine the performance of hADSCs cultured on different substrates. [ACS Appl Mater Interfaces] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITRORepair of Calvarial Bone Defect Using Jarid1a-Knockdown Bone Mesenchymal Stem Cells in Rats To define the function and regulatory mechanisms of Jarid1a in the osteogenic differentiation of bone mesenchymal stem cells (BMSCs), investigators compared the expression of Jarid1a between undifferentiated and osteo-inductive BMSCs. Knockdown of Jarid1a by small interfering RNA enhanced osteogenic differentiation of BMSCs in vitro. [Tissue Eng Part A] Abstract The authors sequenced microRNAs from exosomes isolated from marrow-derived MSCs from patients with acute myeloid leukemia and from healthy controls. [Stem Cell Rev] Full Article IN VIVOBy performing in vitro and in vivo studies with MSCs, and lipopolysaccharide-induced mouse calvarial osteolytic bone defect model, scientists found that LL37 significantly promoted cell differentiation, migration, and proliferation in both unmodified MSCs and BMP2 gene modified MSCs. [Mol Ther] Abstract This Phase I, first in human, first in class clinical study evaluated the safety, tolerability and efficacy of treatment with genetically modified mesenchymal stromal cells in combination with ganciclovir. MSC_apceth_101 are genetically modified autologous MSCs used as vehicles for a cell-based gene therapy in patients with advanced gastrointestinal adenocarcinoma. [Oncotarget] Full Article Investigating the advanced glycation end-product-albumin from activated macrophages is critical in both muscle cell and stem cell death, the authors evaluated the recovery of post-ischemic reperfusion injury critical limb ischemia by injection of human bone marrow derived mesenchymal stem cells (MSCs) with or without soluble receptor for AGEs. [Sci Rep] Full Article An Engineered Biomarker System to Monitor and Modulate Immune Clearance of Cell Therapies Researchers studied a unique feature of cell transplant pharmacology—namely, immune clearance—using mesenchymal stromal cells (MSCs) as a proof-of-concept cell therapy. Using this engineered reporter, they observed specific sensitivity of cell therapy exposure to the preparation of cells, cytolysis of MSCs in an allogeneic setting and a NK cell-mediated destruction of MSCs in an autologous setting. [Cytotherapy] Abstract Scientists determined the protective effects of Nrf2-transfected human amniotic mesenchymal stem cells (hAMSCs) against lipopolysaccharide-induced lung injury in mice. Nrf2-overexpressing hAMSCs also exhibited increased cell retention in the lung, more efficient differentiation into AT II cells, and more prominent effects on the increased mRNA and protein expression as well as DNA-binding activity of Nrf2 than control. [J Cell Biochem] Abstract Researchers investigated the immunomodulatory properties of MSC in an acute and chronic model of lipopolysaccharide (LPS)-induced inflammation, emphysema and atherosclerosis development in APOE*3-Leiden mice. [PLoS One] Full Article | |
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REVIEWSThe authors focus on the formation of biomaterial substrate-mediated multicellular spheroids and their applications in tissue engineering and tumor models. They describe the special chitosan substrate-derived mesenchymal stem cell spheroids and their greater regenerative capacities in various tissues. [Biotechnol J] Abstract Mammalian MSC from Selected Species: Features and Applications Multiple differentiation potential into at least the osteogenic, adipogenic, and chondrogenic lineage is a main criterion for MSC definition. Human MSC and MSC of a variety of mammals isolated from different tissues meet these criteria. [Cytometry A] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSBioLife Solutions, Inc. announced that Cellular Biomedicine Group has validated BioLife’s proprietary CryoStor freeze media for use in immunotherapies for cancer and stem cell therapies for degenerative diseases planned US Phase I clinical trial of AlloJoin, an off the shelf allogeneic stem cell therapy for knee osteoarthritis. [BioLife Solutions, Inc.] Press Release Axolotl Biologix Launches AxoBioFluid A™ an Ambient Temperature Amnion-Derived Allograft Fluid Axolotl Biologix announced that it will begin shipping its third amniotic allograft product, AxoBioFluid® A on October 1st of this year. [Axolotl Biologix] Press Release | |
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POLICY NEWSThey Got Hundreds of Thousands to Rally. Where Does the March for Science Go from Here? The hundreds of thousands of people who rallied on the National Mall and in cities worldwide for the March for Science came to be noticed. But as two dozen of them met in New York the following month for a debrief, they faced an obvious reality: A grass-roots organization that was quickly formed to plan a singular event was not, at least immediately, equipped for far-reaching and long-term science advocacy. [STAT News] Editorial After Uproar, U.K. Parliament’s Science Committee Now Has a Female Member The House of Commons Science and Technology Committee tweeted that it was “pleased to announced our membership has been confirmed.” Parliamentary committees had been dissolved after the recent U.K. election, and now the panel was rolling out its new contingent of lawmakers. [ScienceInsider] Editorial U.S. House Approves 2018 Spending Bills, but Process Far from Finished The U.S. House of Representatives took a major step toward setting federal science budgets for the 2018 fiscal year. But Congress is still far from the finish line, and final spending levels aren’t likely to be finalized until late this year at the earliest. [ScienceInsider] Editorial
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EVENTSNEW Keystone Symposia: Novel Aspects of Bone Biology Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Positions – Tissue Regeneration and Engineering (Duke University) NEW Assistant or Associate Professor – Biomedical Engineering (University of British Columbia) Faculty Position – Stem Cell Biology (University of Texas Southwestern Medical Center) Researcher – Skeletal Tissue Engineering (KU Leuven) Faculty Position – Regenerative Biology (Northwestern University) Professor – Bioengineering (University of Pittsburgh) Assistant Professor – Human Anatomy and Cell Science (University Of Manitoba) PhD Position – Stem Cells and Tissue Engineering (Queensland University of Technology) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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