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Pulmonary Cell News| Mesenchymal Cell News 9.44 November 7, 2017 | |
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TOP STORYOsteoblast Production by Reserved Progenitor Cells in Zebrafish Bone Regeneration and Maintenance Researchers found from cell-lineage tracing and ablation experiments that a group of cells reserved in niches serves as osteoblast progenitor cells (OPCs) and have a significant role in fin ray regeneration. They further showed that OPCs are derived from embryonic somites, as is the case with embryonic osteoblasts, and are replenished from mesenchymal precursors in adult zebrafish. [Dev Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROThe authors investigated the cellular behaviors of bone marrow mesenchymal stem cells after incubation in different conditioned media generated by unpolarized macrophages (Mφs) or polarized Mφs. [J Cell Mol Med] Full Article SCARA5 Plays a Critical Role in the Commitment of Mesenchymal Stem Cells to Adipogenesis Using gene expression profile studies, scientists determined that Scavenger receptor class A, member 5 (SCARA5) is a novel mediator of adipocyte commitment. SCARA5 was expressed at a higher level in committed A33 preadipocyte cells compared to C3H10T1/2 pluripotent stem cells. [Sci Rep] Full Article Using expression analysis of components and target genes, investigators showed that pathway activity was restricted to the mesenchymal and epithelial progenitor pools. Inhibition of retinoic acid signaling in ureter explant cultures resulted in tissue hypoplasia with a relative expansion of smooth muscle cells at the expense of lamina propria fibroblasts in the mesenchyme, and of superficial cells at the expense of intermediate cells in the ureteric epithelium. [Sci Rep] Full Article Scientists investigated the potential of two serum/xeno-free, good manufacturing practice-compliant culture systems to maintain long-term “stemness” of oral MSCs and alveolar bone marrow MSCs, compared to conventional serum-based expansion. [Stem Cell Res Ther] Full Article IN VIVOThe miRNAs sponge potential of lnc-NTF3-5 was assessed through RNA immunoprecipitation, dual luciferase reporter assay, and in vivo ectopic bone formation. The in vivo bone formation study showed that lnc-NTF3-5 and miR-93-3p inhibitor co-transfection group displayed the strongest bone formation. [Clin Implant Dent Relat Res] Full Article Researchers investigated the effect of treatment with allogenic MSCs on survival and liver regeneration 48 hours and 7 days after 80% hepatectomy in C57Bl/6 mice. To optimize their biodistribution, MSCs were grown on acellular human amniotic membranes and applied as a patch on the remnant liver. [J Tissue Eng Regen Med] Abstract Scientists investigated the use of a lentiviral vector containing the mCherry fluorescent reporter gene to transduce and label endometrial MSCs following in vitro culturing in A83-01-containing medium, and different methods of tracing the labelled cells following transplantation under the kidney capsule of immunocompromised NSG mice. [Stem Cells Dev] Abstract Investigators developed a method for collecting porcine brain extract and investigated its effects on osteogenic differentiation of rat bone marrow derived mesenchymal stem cells and bone consolidation in a rat distraction osteogenesis model. [PLoS One] Full Article Researchers investigated the efficacy of three-dimensional scaffolds of silk fibroin/chitosan/nano-hydroxyapatite and bone marrow derived mesenchymal stem cells on the repair of long segmental bone defects in rabbits. [Biomed Pharmacother] Abstract | |
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REVIEWSThe authors highlight the limitations of musculoskeletal regeneration and summarize the most relevant acellular tissue engineering approaches. They focus on the strategies that could be most effectively translate in clinical practice and reflect on contemporary and cutting-edge regenerative strategies in surgery. [Stem Cells Transl Med] Full Article The Therapeutic Potential of Bone Marrow Mesenchymal Stem Cells in Myocardial Infarction Researchers examine recent literature concerning the application of bone marrow mesenchymal stem cells (BMSCs) for the treatment of myocardial infarction and consider the following aspects: activity of transplanted cells, migration and homing of BMSCs, immunomodulatory and anti-inflammatory effects of BMSCs, anti-fibrotic activity of BMSCs, the role of BMSCs in angiogenesis, and differentiation of BMSCs into cardiomyocyte-like cells and endothelial cells. [Stem Cell Res Ther] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSCellular Biomedicine Group Inc. announced the establishment of a strategic partnership with Thermo Fisher Scientific (China) Ltd. to build a joint Cell Therapy Technology Innovation and Application Center at CBMG’s newly opened Shanghai Zhangjiang GMP facility. [Cellular Biomedicine Group Inc.] Press Release $10 Million Gift Supports Personalized Medicine Washington University School of Medicine in St. Louis has received a $10 million commitment from longtime benefactors George and Debra Couch to support research that advances personalized medicine. [Washington University School of Medicine] Press Release | |
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POLICY NEWSCourt Demands that Search Engines and Internet Service Providers Block Sci-Hub The American Chemical Society (ACS) has won a lawsuit against Sci-Hub, a website providing illicit free access to millions of paywalled scientific papers. ACS had alleged copyright infringement, trademark counterfeiting and trademark infringement; a district court in Virginia ruled that Sci-Hub should pay the ACS $4.8 million in damages after Sci-Hub representatives failed to attend court. [ScienceInsider] Editorial When Representative Lamar Smith announced that he would not run for re-election in 2018, after 32 years in Congress, many scientists reacted with glee. [ScienceInsider] Editorial Leading Western Publisher Bows to Chinese Censorship Springer Nature, whose publications include Nature and Scientific American, acknowledged that at the government’s request, it had removed articles from its mainland site that touch on topics the ruling Communist Party considers sensitive, including Taiwan, Tibet, human rights and elite politics. [The New York Times] Editorial
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EVENTSNEW 25th Biennial Congress of the European Association for Cancer Research (EACR) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PI Positions – Developmental Biology and Stem Cell Research (Hubrecht Institute) NEW Research Scientist – Global Research for Stem Cells (Novo Nordisk) Postdoctoral Position – Stem Cell Therapy (University of Southern Denmark) Research Assistant – Tissue Repair (Structural Genomics Consortium, University of Oxford) Postdoctoral Fellow – Cardiac Recovery after Myocardial Infarction (University of Kentucky) Assistant Professor – Stem Cell And Regenerative Biology (Columbia University) Faculty Positions – Tissue Regeneration and Engineering (Duke University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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