Mesenchymal Cell News Volume 9.45 | Nov 14 2017

TOP STORY

Mitochondrial Oxidative Stress Reduces the Immunopotency of Mesenchymal Stromal Cells in Adults with Coronary Artery Disease

Researchers assessed the role of mitochondrial dysfunction in the impaired immunomodulatory properties of MSCs from atherosclerosis (ATH) patients. An impaired mitochondrial function of ATH-MSCs underlies their altered secretome, and reduced immunopotency. [Circ Res] Abstract

(Ranked by impact factor of the journal)

IN VITRO

Molecular Spectrum of Secretome Regulates the Relative Hepatogenic Potential of Mesenchymal Stem Cells from Bone Marrow and Dental Tissue

Scientists investigated the comparative hepatogenic potential of human bone marrow stem cells with stem cells derived from human dental pulp, apical papilla and follicle during this study. Hepatogenic potential of stem cells were assessed by functional assays at both genetic and protein level. [Sci Rep] Full Article

Passage-Dependent Accumulation of Somatic Mutations in Mesenchymal Stromal Cells During In Vitro Culture Revealed by Whole Genome Sequencing

Investigators performed whole genome sequencing of two peripheral blood-derived MSC lines at various passages. [Sci Rep] Full Article

miRNA Profiling of Nurown^®: Mesenchymal Stem Cells Secreting Neurotrophic Factors

Researchers determined whether the miRNA profile could provide a tool for MSC-neurotrophic factor cell characterization and to distinguish them from the matched MSC from which they are derived. [Stem Cell Res Ther] Full Article | Press Release

ω-3 Polyunsaturated Fatty Acids Direct Differentiation of the Membrane Phenotype in Mesenchymal Stem Cells to Potentiate Osteogenesis

Th authors report that differentiation of human mesenchymal stem cells into osteoblasts or adipocytes results in extensive remodeling of the plasma membrane, producing cell-specific membrane compositions and biophysical properties. [Sci Adv] Full Article | Press Release

Coculture of Meniscus Cells and Mesenchymal Stem Cells in Simulated Microgravity

Scientists investigated the effect of simulated microgravity on cocultures of primary human meniscus cells and adipose-derived MSCs. Simulated microgravity significantly enhanced cartilaginous matrix formation in cocultures of primary meniscus cells and adipose-derived MSCs. [npj Microgravity] Full Article

IN VIVO

TGFβ3 Recruits Endogenous Mesenchymal Stem Cells to Initiate Bone Regeneration

In vivo, a 2-mm FVB/N mouse femur defect model was used to evaluate chemokine secretion, endogenous cell homing, and bone regeneration induced by scaffolds loading 1 μg transforming growth factor beta-3 (TGFβ3) through qPCR, immunofluorescent staining, immunohistochemical analysis, and Micro-CT, compared to the vehicle group. [Stem Cell Res Ther] Full Article

Reduction of Protein Phosphatase 2A Cα Promotes In Vivo Bone Formation and Adipocyte Differentiation

Scientists examined the role of the α-isoform of protein phosphatase 2A catalytic subunit (PP2A Cα) in in vivo bone formation by generating transgenic mice, in which the dominant negative form of PP2A Cα was specifically expressed in osteoblasts. [Mol Cell Endocrinol] Abstract | Graphical Abstract

Resveratrol Pretreatment Enhanced Homing of SDF-1α-Preconditioned Bone Marrow-Derived Mesenchymal Stem Cells in a Rat Model of Liver Cirrhosis

A combined strategy was applied to evaluate bone marrow-derived MSCs (BMSCs) homing to the rat model of liver cirrhosis induced by common bile duct ligation: A pretreatment delivery of resveratrol into the cirrhotic liver, and a transplantation of ex vivo BMSC preconditioning with stromal cell-derived factor-1α (SDF-1α). [J Cell Biochem] Abstract

Coculture of Allogenic DBM and BMSCs in the Knee Joint Cavity of Rabbits for Cartilage Tissue Engineering

Investigators assessed coculture of allogenic decalcified bone matrix (DBM) and bone marrow mesenchymal stem cells (BMSCs) in the knee joint cavity of rabbits for cartilage tissue engineering. [Biosci Rep] Full Article

Promoting Neuroregeneration after Perinatal Arterial Ischemic Stroke: Neurotrophic Factors and Mesenchymal Stem Cells

The authors focus on effectiveness of neurotrophic growth factors, including erythropoietin, brain-derived neurotrophic factor, vascular endothelial growth factor, glial-derived neurotrophic factor, and MSC therapy, in both experimental neonatal stroke studies and first clinical trials for neonatal ischemic brain injury. [Pediatr Res] Abstract

Strategies to Enhance Paracrine Potency of Transplanted Mesenchymal Stem Cells in Intractable Neonatal Disorders

Researchers focus on recent investigations that elucidate the specifically regulated paracrine mechanisms of MSCs by injury type and discuss potential strategies to enhance paracrine potency, and thus therapeutic efficacy, of transplanted MSCs, including determining the appropriate source and preconditioning strategy for MSCs and the route and timing of their administration. [Pediatr Res] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

VetCell Therapeutics and Western University Seek Allogeneic Stem Cell Treatment for Canine Atopic Dermatitis

VetCell Therapeutics announced that it has entered into a collaborative clinical study with Western University of Health Sciences, College of Veterinary Medicine, one of only two esteemed veterinary programs in California, to study the efficacy and safety of treating canine atopic dermatitis with mesenchymal stem cells. [VetCell Therapeutics] Press Release

Orthocell Receives CE Mark for CelGro^®

Regenerative medicine company Orthocell Limited announced receipt of European regulatory approval for its CelGro^® collagen medical device. [Orthocell Limited (Business Wire, Inc.)] Press Release

Graduate Students Face Alarming Tax Hike

The last thing that graduate students need is a tax hike. But that is what many would face under a clause in the federal-tax-reform bill passed by the US House of Representatives. It will need to be reconciled with the Senate’s tax-reform bill (which retains many existing student tax benefits), and signed by the president. [Nature News] Editorial

UK Government Appoints Next Chief Scientific Adviser

Patrick Vallance, president of research and development at the pharmaceutical giant GlaxoSmithKline, has been appointed as chief scientific adviser, the UK government announced. [Nature News] Editorial

NEW Gordon Research Conferences: Bones and Teeth
January 28-February 2, 2018
Galveston, Texas, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Positions – Cytokines in Immunity, Stem Cells and Tissue Repair (Hospital for Special Surgery and Weill Cornell Medicine)

PI Positions – Developmental Biology and Stem Cell Research (Hubrecht Institute)

Research Scientist – Global Research for Stem Cells (Novo Nordisk)

Postdoctoral Position – Stem Cell Therapy (University of Southern Denmark)

Postdoctoral Fellow – Cardiac Recovery after Myocardial Infarction (University of Kentucky)

Assistant or Associate Professor – Sarcoma/Melanoma Surgery (The University of Texas MD Anderson Cancer Center)

Assistant/Associate Professors – Developmental and Regenerative Biology (The Chinese University of Hong Kong)

Assistant Professor – Stem Cell And Regenerative Biology (Columbia University)

Postdoctoral Trainee – Cardiovascular Biology and Regenerative Medicine (Albert Einstein College of Medicine in New York)

Faculty Positions – Tissue Regeneration and Engineering (Duke University)

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