Mesenchymal Cell News 9.48 December 5, 2017 | |
| |
TOP STORYThe authors performed a global profiling of differentially expressed miRNAs in bone marrow-derived skeletal cells during in vitro osteoblast differentiation. [Mol Ther] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)IN VITROResearchers developed a method for long-term drug modification to C3H10T1/2 cells, murine mesenchymal stem cells, without any damage, using the avidin-biotin complex method. [Sci Rep] Full Article The neurogenic potential of adipose tissue – derived human mesenchymal stem cells was evaluated in vitro. The expression pattern and localization of vimentin confirmed the mesenchymal origin of cells and tracked morphological changes during differentiation. [Sci Rep] Full Article Investigators studied FSK-MSCs-NK interaction and showed that the result of such cross talk was robustly dependent on the type of cytokines employed to activate NK cells. Distinctly activated-NK cells showed uneven cytotoxicity against FSK-MSCs, triggering their death in fine. [J Cell Physiol] Abstract Scientists investigated single-cell RNA-sequencing data for identification of differentially expressed genes in 12 mouse-derived single spermatogonial stem cells and compared these with 16 mouse-derived single mesenchymal stem cells. [J Cell Physiol] Abstract IN VIVOResearchers investigated whether persistent and adaptive hypoxia treatment of bone marrow MSCs prior to their transplantation in injured mice enhanced survival and improved curative effects in radiation-induced lung injury. [Cell Physiol Biochem] Full Article Scientists evaluated the therapeutic efficacy and mechanisms of miR-133-overexpressing MSCs on acute myocardial infarction. [Stem Cell Res Ther] Full Article CD105+-Mesenchymal Stem Cells Migrate into Osteoarthritis Joint: An Animal Model The authors investigated the risk of xenogenicity of human synovial membrane-derived MSCs, injected into the monkeys using intravenous and intra-articular administration. [PLoS One] Full Article Investigators evaluated the feasibility, safety, and biocompatibility of intravitreal injection of human MSCs in immunocompetent pigmented rabbits. [Graefes Arch Clin Exp Ophthalmol] Abstract | |
| |
REVIEWSThe Future of Mesenchymal Stem Cell-Based Therapeutic Approaches for Cancer – From Cells to Ghosts Many questions are still unanswered regarding the biology of MSCs in normal and pathophysiological settings. In addition to summarizing the current state of MSC-based therapeutic approaches for cancer, the authors describe the remaining questions, obstacles and risks, as well as novel developments such as MSC-derived nanoghosts. [Cancer Lett] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
| |
INDUSTRY NEWSTWOCELLS Co., Ltd. announced that the first patient has undergone surgery in the Phase III comparative trial of “gMSC®1”. [Chugai Pharmaceutical Co., Ltd.] Press Release Regentis Biomaterials Performs the First Cases in Gelrinc Pivotal Study Regentis Biomaterials announced the start of its Phase III pivotal clinical trial of GelrinC for the treatment of focal knee cartilage defects with successful surgery on three patients in the U.S. and Denmark. [Regentis Biomaterials] Press Release | |
| |
POLICY NEWSTrump Science Job Nominees Missing Advanced Science Degrees When it comes to filling jobs dealing with complex science, environment, and health issues, the Trump administration is nominating people with fewer science academic credentials than their Obama predecessors. And it’s moving slower as well. [STAT News] Editorial Biohackers Disregard FDA Warning on DIY Gene Therapy Despite a warning from the federal government about do-it-yourself (DIY) gene therapy, two companies say they’ll continue offering DNA-altering materials to the public. The companies, The Odin and Ascendance Biomedical, both recently posted videos online of people self-administering DNA molecules their labs had produced. [MIT Technology Review] Editorial Health Agency Reveals Scourge of Fake Drugs in Developing World One in ten medicines in developing countries is fake or substandard, data from the World Health Organization suggest. Malaria drugs and antibiotics are among the most commonly reported, the agency found. But the problem extends to a variety of medications, including those for cancer, heart disease and HIV, as well as contraceptives and painkillers. [Nature News] Editorial
| |
EVENTSNEW Cold Spring Harbor (CSH): Mouse Development, Stem Cells & Cancer Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Research Position – Mesenchymal Stem Cells (Università degli Studi di Genova) NEW Chair – Models of Regeneration (The Technische Universität Dresden) Research Technologist – Mesenchymal and Endothelial Cells (STEMCELL Technologies Inc.) Postdoctoral Researchers – Stem Cell Metabolism (University of Helsinki) Postdoctoral Fellows – Stem Cell Biology and Regenerative Medicine (Stanford University) PI Positions – Developmental Biology and Stem Cell Research (Hubrecht Institute) Postdoctoral Fellow – Cardiac Recovery after Myocardial Infarction (University of Kentucky) Assistant Professor – Stem Cell And Regenerative Biology (Columbia University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Mesenchymal Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|