 | | Vol. 14.15 – 19 April, 2022 |
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| A human MSC-derived miniature joint system was generated, in which engineered osteochondral complex, synovial-like fibrous tissue, and adipose tissue were integrated into a microfluidics-enabled bioreactor.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that the lymph nodes contain immunosupportive MSCs. They produced and secreted a high level of MCP-1 to promote T cell proliferation and differentiation, in contrast to bone marrow MSCs, which repressed T cell activation.
[Cell Death & Disease] |
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| Researchers identified the suppressing roles of exosomal miR-15a-5p from umbilical cord mesenchymal stem cells in the EMT and metastasis of cholangiocarcinoma.
[Cell Death Discovery] |
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| The expression of Oct4 was elevated when the chondrogenic differentiation (CD) of cultured MSCs was induced. Silencing Oct4 damaged MSC growth and proliferation and decreased CD, indicated by decreased cartilage matrix formation and the expression of Col2a1, Col10a1, Acan, and Sox9.
[Cell and Tissue Research] |
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| Investigators explored the effect of all-trans retinoic acid (ATRA) on the periodontal ligament stem cells (PDLSCs) osteogenic differentiation. PDLSCs were harvested from the periodontal membrane and treated with or without ATRA.
[International Immunopharmacology] |
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| | Scientists observed reduced osteoblast number and bone formation in lipopolysaccharide (LPS)-induced bone loss mice. Levels of circulating exosomes were increased by ~ twofold in LPS mice, and the expression of exosomal miRNAs was significantly changed.
[Calcified Tissue International] |
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| The authors established some important characteristics that can be used to distinguish between MSC-NTF and MSCs: different multi-factor secretion ability and secretion characteristics, immunogenicity, three-line differentiation ability, stemness, etc.
[Experimental Cell Research] |
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| A gamma-glutamyltransferase knockout Helicobacter. pylori strain was constructed, and downstream histone H3K9 and H3K27 methylation and the PI3K/AKT signaling pathway of alpha-ketoglutarate were detected using Western blotting. The biological characteristics of MSCs were also examined.
[Journal of Microbiology] |
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| Researchers assessed the effect of human umbilical cord blood mesenchymal stem cells transplantation on schistosomal hepatic fibrosis in mice.
[Pathogens and Global Health] |
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| Investigators summarize the newly-described capacity of melatonin to improve mitochondrial fusion/fission dynamics and promote tunneling nanotubes formation.
[Journal of Pineal Research] |
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| Scientists assess the effected of MSC therapy on salivary gland function after radiation-induced injury via systematic review.
[Systematic Reviews] |
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| Scientists at Cedars-Sinai are launching their expertise into space to see if they can elevate the next generation of stem cell and gene therapies by harnessing the near-zero gravity conditions of spaceflight.
[Cedars Sinai] |
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| BioRestorative Therapies, Inc. announced that it has selected 10 of its 15 clinical sites for its Phase II clinical trial targeting chronic lumbar disc disease.
[BioRestorative Therapies, Inc. (GlobeNewswire, Inc.)] |
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| June 19 – 24, 2022
Smithfield, Rhode Island, United States |
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| | Wayne State University – Detroit, Michigan, United States |
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| | Johns Hopkins University – Baltimore, Maryland, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Novo Nordisk – Fremont, California, United States |
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| | Cancer Research UK Manchester Institute – Manchester, England, United Kingdom |
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