Mesenchymal Cell News Volume 14.28 | Jul 19 2022

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    2022-07-19 | MESCN 14.28


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.28 – 19 July, 2022
    TOP STORY

    Paracrine-Mediated Rejuvenation of Aged Mesenchymal Stem Cells Is Associated with Downregulation of the Autophagy-Lysosomal Pathway

    To help understand the effect of age on stem cell potency, bone marrow-derived MSCs were isolated from young and old mice.
    [npj Aging and Mechanisms of Disease]

    Full Article
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    PUBLICATIONSRanked by the impact factor of the journal

    Enhancing Metabolic Activity and Differentiation Potential in Adipose Mesenchymal Stem Cells via High-Resolution Surface-Acoustic-Wave Contactless Patterning

    Investigators developed a standing surface acoustic wave-based platform and demonstrated its capability for the well-controlled and rapid cell patterning of adipose-derived MSCs in a high-density homogenous collagen hydrogel.
    [Microsystems & Nanoengineering]

    Full ArticleGraphical Abstract

    Differences in Chemotaxis of Human Mesenchymal Stem Cells and Cervical Cancer Cells

    Researchers isolated different MSCs from various human tissues including adipose, umbilical cord, amniotic membrane, and chorion.
    [Apoptosis]

    Abstract

    Mesenchymal Stem Cells Promote Spermatogonial Stem/Progenitor Cell Pool and Spermatogenesis in Neonatal Mice In Vitro

    Scientists explored whether a co-culture setup supported by syngeneic bone marrow-MSC that contributed to the air–liquid interphase could lead to survival, expansion, and differentiation of spermatogonial stem/progenitor cells in vitro.
    [Scientific Reports]

    Full Article

    Melatonin Protects Gingival Mesenchymal Stem Cells and Promotes Differentiation into Osteoblasts

    Investigators studied the antioxidant and differentiating effect of melatonin on an in vitro system of gingiva-derived MSCs.
    [Cell Biochemistry and Function]

    Abstract

    Tumor Suppressive Role of MicroRNA-139-5p in Bone Marrow Mesenchymal Stem Cells-Derived Extracellular Vesicles in Bladder Cancer through Regulation of the KIF3A/p21 Axis

    A nude mouse model of subcutaneous xenograft tumor was constructed to detect the effect of miR-139-5p in bone-marrow MSCs-extracellular vesicles on the tumorigenesis and lung metastasis of bladder cancer cells in vivo.
    [Cell Death & Disease]

    Full Article

    Effects of Human Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells on Airway Inflammation and Remodeling in a Murine Model of Chronic Asthma

    Scientists assessed the effects of MSC treatments using a murine model of chronic ovalbumin-challenged asthma.
    [Scientific Reports]

    Full Article

    Intratracheal Administration of Mesenchymal Stem Cells Modulates Lung Macrophage Polarization and Exerts Anti-Asthmatic Effects

    Researchers investigated the effects of direct MSC administration on asthmatic airways. Umbilical cord MSCs were intratracheally administered to six-week-old female BALB/c mice sensitized and challenged with ovalbumin.
    [Scientific Reports]

    Full Article

    Mesenchymal Stem Cell-Derived Extracellular Vesicle-Enclosed MiR-93 Prevents Hypoxic-Ischemic Brain Damage in Rats

    The authors clarified the mechanism of MSC-derived extracellular vesicles containing microRNA-93 in influencing this damage via regulation of the histone deacetylase 4/B-cell lymphoma-2 axis.
    [Neuroscience]

    Abstract
    Listen to the Stem Cell Podcast episodes covering ISSCR 2022 sessions.
    REVIEWS

    Mesenchymal Stromal Cells: Promising Treatment for Liver Cirrhosis

    Investigators summarize the characteristics of MSCs, representative clinical study data, and the potential mechanisms of MSC-based strategies for attenuating liver cirrhosis.
    [Stem Cell Research & Therapy]

    Full Article

    TA-MSCs, TA-MSCs-EVs, MIF: Their Crosstalk in Immunosuppressive Tumor Microenvironment

    The authors summarize the main effects and related mechanisms of tumor-associated MSCs (TA-MSCs), TA-MSCs-derived extracellular vesicles (MSCs-EVs), and migration inhibitory factor (MIF) on tumors, and describe their relationships.
    [Journal of Translational Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Antengene Announces Research Collaboration with Celularity to Evaluate the Potential Therapeutic Synergy of Combining Antengene’s Best-in-Class Bispecific Antibody with Celularity’s Natural Killer Cell Platform

    Antengene Corporation Limited announced that it has entered into a pre-clinical research collaboration with Celularity, Inc., a clinical-stage biotechnology company developing placental-derived allogeneic cell therapies.
    [Antengene Corporation Ltd (Cision US Inc.)]

    Press Release
    FEATURED EVENT

    GISM Annual Meeting 2022

    October 20 – 21, 2022
    Turin, Italy

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Combined Omics

    UT Health Science Center at San Antonio – San Antonio, Texas, United States

    Postdoctoral Researcher – Microfluidics, Organoids, and Precision Medicine

    Lehigh University – Bethlehem, Pennsylvania, Untied States

    Director – Bone & Soft Tissue Pathology

    Michigan Medicine – Ann Arbor, Michigan, United States

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Postdoctoral Position – Sarcoma Pathology

    The University of Iowa – Iowa City, Iowa, United States

    > See All Jobs

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