Muscle Cell News 1.20 August 8, 2016 | |
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TOP STORYMRF4 Negatively Regulates Adult Skeletal Muscle Growth by Repressing MEF2 Activity Investigators showed that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthesis and widespread activation of muscle-specific genes, many of which are targets of MEF2 transcription factors. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSInvestigators showed that superimposition of estrogen-related receptor gamma on the myostatin mouse null background results in hypertrophic muscle with a high oxidative capacity thus violating the inverse relationship between fiber size and oxidative capacity. [eLife] Full Article Tmem2 Regulates Cell-Matrix Interactions that Are Essential for Muscle Fiber Attachment Scientists demonstrated the impact of transmembrane protein 2 (tmem2) on cell-matrix interactions during muscle morphogenesis in zebrafish. [Development] Abstract The authors engineered microscale progenitor cardiac spheres from human pluripotent stem cells and exposed the spheres to simulated microgravity using a random positioning machine for 3 days during their differentiation to cardiomyocytes. [Sci Rep] Full Article Investigators hypothesized whether doxorubicin caused myocyte injury by impairing lysosomal function and signaling through negative regulation of transcription factor EB. [Biochem J] Abstract SKELETAL MUSCLE CELLSAdhesion and Fusion of Muscle Cells Are Promoted by Filopodia Indirect flight muscles in Drosophila are generated during pupariation by fusion of hundreds of myoblasts with larval muscle templates (myotubes). Live observation of these muscles during the fusion process revealed multiple long actin-based protrusions that emanate from the myotube surface and require Enabled and IRSp53 for their generation and maintenance. [Dev Cell] Abstract | Graphical Abstract The mouse skeletal muscle cells cell line C2C12, wild type mouse muscle tissue and primary mouse muscle cells were analyzed using quantitative PCR, western blotting and immuno-histochemical stainings as well as functional analysis including patch-clamp measurements and Ca2+-imaging. [Am J Physiol, Cell Physiol] Abstract Researchers designed a method to deliver a vibration stress and systemic heat stress to compare the effects with active skeletal muscle contraction. [PLoS One] Full Article SMOOTH MUSCLE CELLSβ-Catenin C-Terminal Signals Suppress p53 and Are Essential for Artery Formation Scientists found that embryos lacking smooth muscle cells (SMCs) β-catenin suffer impaired arterial maturation and die by E12.5, with increased vascular wall p53 activity. β-Catenin-deficient SMCs showed no change in p53 levels, but greater p53 acetylation and activity, plus impaired growth and survival. [Nat Commun] Full Article Researchers investigated if NF-E2 related factor 2 (Nrf2) mediates the anti-senescent effect of Exendin-4 in angiotensin II-induced VSMCs. [Am J Physiol, Cell Physiol] Abstract | |
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REVIEWSRegulatory T Cells and Skeletal Muscle Regeneration Skeletal muscle regeneration results from the activation and differentiation of myogenic stem cells, called satellite cells, located beneath the basal lamina of the muscle fibers. Inflammatory and immune cells have a crucial role in the regeneration process. [FEBS J] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSPfizer Aims to Become Industry Leader in Gene Therapy with Acquisition of Bamboo Therapeutics, Inc. Pfizer Inc. announced that it has acquired Bamboo Therapeutics, Inc. focused on developing gene therapies for the potential treatment of patients with certain rare diseases related to neuromuscular conditions and those affecting the central nervous system. [Pfizer Inc.] Press Release Southwest National Primate Research Center at Texas Biomed receives $40 million NIH grant The Southwest National Primate Research Center at Texas Biomedical Research Institute was awarded more than $40 million for a National Institutes of Health P51 grant through 2021 to continue research programs using nonhuman primates as part of the National Primate Research Center consortia. [Texas Biomedical Research Institute] Press Release | |
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EVENTSNEW Organoids: Modeling Organ Development and Disease in 3D Culture Visit our events page to see a complete list of events in the muscle cell community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Cardiovascular Stem Cell Biology (Yale University) Postdoctoral Research Fellowship – Functional Genomics and Bioinformatics (L’Institut du Thorax) Postdoctoral Position – Biomedical Engineering (University of South Dakota) Postdoctoral Position – Duchenne Muscular Dystrophy (Leiden University Medical Center) Group Leader – Cardio Pulmonary Science (Justus-Liebig-Universität Gießen) Postdoctoral Fellow – Muscle Energetics (National Institutes of Health) Postdoctoral Fellow – Skeletal Muscle Biology (University of Texas Health Science Center) Post-Doc/Associate Specialist – Autophagy (Nestlé Institute of Health Sciences) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 1.20 | Aug 8 2016