Muscle Cell News 1.27 October 3, 2016 | |
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TOP STORYCardiosphere-derived cell exosomes delivered intramyocardial (IM) decrease scarring, halt adverse remodeling and improve left ventricular ejection fraction in porcine acute and convalescent myocardial infarction. While conceptually attractive as cell-free therapeutic agents for myocardial infarction, exosomes have the disadvantage that IM delivery is necessary. [Eur Heart J] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSInvestigators tested the hypothesis that mesenchymal stem cells stimulate endogenous cardiac cKit+ cells to proliferate, migrate, and differentiate via the SDF1/CXCR4 and stem cell factor/cKit pathways. [Circ Res] Full Article Scientists aimed to explore the relationship between miR-185 and dilated cardiomyopathy progression. [Sci Rep] Full Article Researchers sought to investigate the inhibitory effects of hesperetin on human cardiac nav 1.5 channels stably expressed in human embryonic kidney 293 (HEK 293) cells and on the voltage-gated cardiac sodium current in human atrial myocytes. [Acta Pharmacol Sin] Abstract SKELETAL MUSCLE CELLSDysferlin-Mediated Phosphatidylserine Sorting Engages Macrophages in Sarcolemma Repair Investigators showed that membrane repair is a multi-tiered process involving immediate, cell-intrinsic mechanisms as well as myofiber/macrophage interactions. [Nat Commun] Full Article Muscle Satellite cells (SCs) from samples from rodents and human subjects with type 1 diabetes were examined to discern differences in SC density and functionality compared with samples from their respective control subjects. Examination of the Notch pathway was undertaken to investigate its role in changes to SC functionality. [Diabetes] Abstract A Human In Vitro Model of Duchenne Muscular Dystrophy Muscle Formation and Contractility Researchers hypothesized that Duchenne muscular dystrophy myoblasts are less sensitive to cues in the extracellular matrix designed to potentiate structure–function relationships of healthy muscle. To test this hypothesis, they drew inspiration from the tongue and engineered contractile human muscle tissues on thin films. [J Cell Biol] Abstract | Press Release Scientists sought to identify critical pathways altered in muscle that underlie disease manifestations in AR113Q mice. This led to the unanticipated identification of gene expression changes affecting regulators of carbohydrate metabolism, similar to those triggered by denervation. [Cell Rep] Full Article | Graphical Abstract HMGB2 Regulates Satellite Cell-Mediated Skeletal Muscle Regeneration via IGF2BP2 Scientists identified HMGB2 as an essential nuclear transcriptional co-regulator in myogenesis. [J Cell Sci] Abstract SMOOTH MUSCLE CELLSThe authors assessed whether proliferation and plasticity in disease is a general characteristic of vascular smooth muscle cell (VSMCs) or a feature of a subset of cells. [Circ Res] Abstract Investigators designed a study to determine the interaction between Ang-(1–7) and Ang II on vascular smooth muscle cells (VSMCs) proliferation, migration and inflammation as well as their underlying mechanisms. [Sci Rep] Full Article Eotaxin Augments Calcification in Vascular Smooth Muscle Cells The authors observed that eotaxin increases the rate of calcification significantly in VSMCs as evidenced by increased alkaline phosphatase activity, calcium deposition, and osteogenic marker expression. In addition, eotaxin promotes proliferation in VSMCs and triggers oxidative stress in a NADPH oxidase dependent manner. [J Cell Biochem] Abstract | |
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REVIEWSRecent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy In this review, the authors summarize recent breakthroughs in an in vivo laminopathy model and in vitro study using patient-specific human induced pluripotent stem cells that reproduce the pathophysiological phenotype for further drug screening. [Stem Cell Res Ther] Full Article Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWS$8 Million Grant to Support Research to Repair Hearts with Bioengineered Patch To prevent heart failure and restore heart function, researchers at the University of Alabama at Birmingham, the University of Wisconsin-Madison and Duke University will work to create a bioengineered, human heart-tissue patch that is large, standardized and highly functional. This preclinical work will be supported by a seven-year, $8 million grant just awarded by the National Heart, Lung, and Blood Institute. [University of Alabama at Birmingham] Press Release The National Science Foundation (NSF) has awarded the University of Pennsylvania a $24 Million, five-year grant to establish a Science and Technology Center (STC) focused on engineering mechanobiology, or the way cells exert and are influenced by the physical forces in their environment. This award is part of an overall $94 million from NSF to support four new STCs. In addition to these latest awards NSF supports eight other STCs. [The University of Pennsylvania] Press Release This year’s Nobel Laureate discovered and elucidated mechanisms underlying autophagy, a fundamental process for degrading and recycling cellular components. [Nobel Prize] Press Release | Editorial Summit Therapeutics plc announced that it has received Rare Pediatric Disease designation from the US Food and Drug Administration (FDA) for ezutromid in the treatment of Duchenne muscular dystrophy (DMD). As a utrophin modulator, ezutromid has potential as a disease-modifying treatment for all patients with the fatal muscle wasting disease DMD, regardless of their underlying dystrophin gene mutation. [Summit Therapeutics plc] Press Release | |
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POLICY NEWSDemocratic Databases: Science on GitHub Scientists are turning to a software–development site to share data and code. [Nature Toolbox] Editorial Biologists Plan Scoring System for Antibodies Biomedical experts plan to create a scoring system that will help researchers choose reliable antibodies for their experiments. The only problems: figuring out how such a ranking would work — and getting manufacturers to adopt the standard. [Nature News] Editorial UK Bioethicists Eye Designer Babies and CRISPR Cows From designer babies to engineered mosquitoes, advances in genome-editing technologies such as CRISPR–Cas9 have raised the possibility of tremendous scientific advances — and serious ethical concerns. [Nature News] Editorial
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EVENTSNEW Advances in Cell Engineering, Imaging and Screening Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Position (Tenure) – Cardiovascular Biology (University of Maryland School of Medicine) National Field Product Service Specialist (Cook MyoSite) Research and Development Specialist- Muscle Stem Cell (Nestlé Institute of Health Sciences) Postdoctoral Position – Lipid Metabolism (Baylor College of Medicine) Project Scientist – Muscle Metabolism (University of California, Berkeley) Chair – Medical Biology (Masaryk University) Faculty Positions – Cell and Molecular Physiology (Loyola University Chicago) Faculty Positions – Genetics and Genomics (Boston University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 1.27 | Oct 3 2016