Muscle Cell News 2.01 January 16, 2017 | |
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TOP STORYA p53 Based Genetic Tracing System to Follow Postnatal Cardiomyocyte Expansion in Heart Regeneration Investigators established a p53 based genetic tracing system to investigate postnatal cardiomyocyte proliferation and heart regeneration. By selectively tracing the proliferative cardiomyocytes, a differential pattern of clonal expansion in p53+ cardiac myocytes was revealed in neonatal, adolescent and adult stages. [Development] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSThe authors showed that Pnmt+ cells are predominantly localized to the left side of the adult heart. Remarkably, many of the Pnmt+ cells in the left atrium and ventricle appeared to be working cardiomyocytes based on their morphological appearance and functional properties. [Sci Rep] Full Article Myeloid Leukemia Factor-1 Is a Novel Modulator of Neonatal Rat Cardiomyocyte Proliferation Researchers focused on the identification of the gene expression profile of neonatal rat cardiomyocytes after dynamic mechanical stretch through microarrays of RNA isolated from cells stretched for 2, 6 or 24 hours. [Biochim Biophys Acta] Abstract SKELETAL MUSCLE CELLSParacrine Cross-Talk between Skeletal Muscle and Macrophages in Exercise by PGC-1α-Controlled BNP Scientists demonstrated that besides a dominant role in controlling cellular metabolism, the peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) also has a profound effect on cytokine expression in muscle tissue. Muscle PGC-1α expression resulted in activation of tissue-resident macrophages, at least in part mediated by PGC-1α-dependent B-type natriuretic peptide (BNP) production and secretion. [Sci Rep] Full Article Myoblast Replication Is Reduced in the IUGR Fetus Despite Maintained Proliferative Capacity In Vitro To explore the basis of restricted fetal muscle growth, investigators used a sheep model of progressive placental insufficiency-induced intrauterine growth restriction (IUGR) to assess myoblast proliferation within intact skeletal muscle in vivo and isolated myoblasts stimulated with insulin in vitro. [J Endocrinol] Abstract MicroRNA-432 Targeting E2F3 and P55PIK Inhibits Myogenesis through PI3K/AKT/mTOR Signaling Pathway Researchers found that microRNA (miR)-432 is able to down-regulate E2F transcription factor 3 (E2F3) to inactivate the expression of cell cycle and myogenic genes. They also identified that phosphatidylinositol 3-kinase regulatory subunit (P55PIK) is another target gene of miR-432 in muscle cells. [RNA Biol] Abstract SMOOTH MUSCLE CELLSInvestigators demonstrated a novel method to generate smooth muscle cell (SMC)-like cells from human dermal fibroblasts by transdifferentiation to study the effect of variants in genes encoding proteins of the SMC contractile apparatus in patients with aortic aneurysms. [Hum Mutat] Abstract Scientists analyzed the potential of S100A8 to regulate allergen-induced airway hyperresponsiveness and airway smooth muscle contraction. Treatment with recombinant S100A8 diminished airway hyperresponsiveness in OVA-sensitized rats. [Biochem Biophys Res Commun] Full Article The authors investigated the role of STriated muscle Activator of Rho Signaling (STARS) in the proliferation of pulmonary arterial smooth muscle cells and the potential effect on the progression of pulmonary arterial hypertension. [Biomed Pharmacother] Abstract Investigators determined the effects of NO2-ox high density lipoprotein (HDL) and Cl-oxHDL on smooth muscle cell migration using wound healing and transwell assays, proliferation using MTT and BrdU assays, and apoptosis using Annexin-V assay in vitro, as well as on atherosclerotic plaque stability in vivo using a coratid artery collar implantation mice model. [Lipids Health Dis] Full Article | |
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REVIEWSLkb1 Regulation of Skeletal Muscle Development, Metabolism and Muscle Progenitor Cell Homeostasis Researchers discuss the roles of liver kinase B1 (Lkb1) in regulating skeletal muscle progenitor cells homeostasis and skeletal muscle development and metabolism. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSNeuroVive Signs Collaboration Agreement with Karolinska Institutet NeuroVive Pharmaceutical AB announced that a collaboration agreement has been signed with Karolinska Institutet regarding development of the company’s compound NV556 for the treatment of mitochondrial myopathy. [NeuroVive Pharmaceutical AB] Press Release Sarepta Therapeutics, Inc. announced it has entered a license agreement with Nationwide Children’s Hospital, for their Galgt2 gene therapy program developed by researcher Dr. Paul Martin, Ph.D. [Nationwide Children’s Hospital] Press Release | |
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POLICY NEWSSurprising Contenders Emerge for Trump’s NIH Chief Could US president-elect Donald Trump be close to choosing a leader for the National Institutes of Health (NIH)? Current NIH chief Francis Collins and Representative Andy Harris (Republican, Maryland), both front-runners for job, met separately with Trump on 11 January, as did billionaire surgeon Patrick Soon-Shiong on 10 January. Several people familiar with the Collins and Harris meetings described them as job interviews. [Nature Breaking News] Editorial European Commission Clears Up Questions on Orphan Drug Regulation Following a public consultation in November 2015, the European Commission has released a new communication intended to clarify some lingering questions about the EU’s Orphan Regulation. The consultation sought to address five issues that have arisen since the Orphan Regulation came into effect in January 2000. [Regulatory Affairs Professionals Society] Editorial
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EVENTSNEW World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Researcher – Actin and Myosin (Linnaeus University) Associate Professorship – Cell Biology & Physiology (University of Copenhagen) Assistant/Associate Professor – Physiology and Cell Biology (University of Nevada) Assistant Professor – Heart Tissue Regeneration (University of Cincinnati) Cell Engineering Scientist – (Oxford Genetics Ltd.) Postdoctoral Fellow – Cardiovascular Research (Thomas Jefferson University) Scientist(s) – Various Biological Research Areas (Sanofi) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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