Muscle Cell News 2.27 August 14, 2017 | |
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TOP STORYUSC Stem Cell Discovery Refreshes the Heart Zebrafish and newborn mammals, including mice and humans, have large numbers of mononuclear diploid cardiomyocytes (MNDCMs) and a relatively robust ability to regenerate heart muscle. However, adult mammals have few MNDCMs and a correspondingly limited capacity for regeneration after an injury such as a heart attack. [Press release from University of Southern California discussing online prepublication in Nature Genetics] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSCardiotrophin 1 Stimulates Beneficial Myogenic and Vascular Remodeling of the Heart Scientists identified the cytokine cardiotrophin 1 as a factor capable of recapitulating the key features of physiologic growth of the heart including transient and reversible hypertrophy of the myocardium, and stimulation of cardiomyocyte-derived angiogenic signals leading to increased vascularity. [Cell Res] Full Article | Press Release To unravel cardiac stem cells identity within the heterogeneous c-kit-expressing cardiac cell population, c-kitpos cardiac cells were separated through CD45-positive or -negative sorting followed by c-kitpos sorting. [Cell Death Differ] Full Article LGR5 expression was transiently upregulated during the early stage of cardiomyocyte differentiation, and knockdown of LGR5 resulted in reduced expression of cardiomyocyte-associated markers and poor cardiac differentiation. [Stem Cell Reports] Full Article | Graphical Abstract Investigators identified the co-regulation of molecular regulators and their interactions during cardiomyocyte specific differentiation of mouse embryonic stem cells based on parallel genome wide transcriptome analyses of mRNA and microRNA. [Biochim Biophys Acta] Abstract | Graphical Abstract SKELETAL MUSCLE CELLSResearchers developed an elastic conductive poly(ethylene glycol)-co-poly(glycerol sebacate) grafted aniline pentamer copolymer that could promote the formation of myotubes by differentiating the C2C12 myoblast cells. [Biomacromolecules] Abstract The authors found that intracellular esterase activity distinguishes a subpopulation of cultured satellite cells with high stemness using esterase-sensitive cell staining reagent, calcein-AM. Gene expression analysis of this subpopulation revealed that defined combinations of transcription factors reprogrammed fibroblasts into skeletal muscle progenitor cells. [Sci Rep] Full Article Using an in vivo skeletal muscle injury model, scientists showed that expression of Ror1 and Ror2 in skeletal muscles is induced transiently by the inflammatory cytokines, TNF-α and IL-1β, after injury, and that inhibition of TNF-α and IL-1β by neutralizing antibodies suppresses expression of Ror1 and Ror2 in injured muscles. [J Biol Chem] Abstract SMOOTH MUSCLE CELLSSRSF1 Promotes Vascular Smooth Muscle Cell Proliferation through a Δ133p53/EGR1/KLF5 Pathway The authors report that serine/arginine-rich splicing factor 1 (SRSF1), an essential splicing factor, promotes vascular smooth muscle cell proliferation and injury-induced neointima formation. [Nat Commun] Full Article Investigators demonstrated that WNK1, a Cl−-sensitive kinase, was involved in volume-regulated Cl− channel-induced proliferative signaling pathway in A10 vascular smooth muscle cells in vitro. [Acta Pharmacol Sin] Full Article Researchers determined the involvement of ADP ribosylation factor and cytohesin in U46619-induced stimulation of phospholipase D (PLD) in pulmonary artery smooth muscle cells, and the probable mechanism by which curcumin, a natural phenolic compound, inhibits the U46619 response. [Mol Cell Biochem] Abstract | |
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REVIEWSThe authors explore recent research investigating the contribution of satellite cells (skeletal muscle stem cells) during muscle fiber atrophy as seen in periods of disuse, illness, and aging. [Curr Opin Clin Nutr Metab Care] Abstract Mapping the Human Skeletal Muscle Proteome: Progress and Potential Researchers critically analyze studies performed on muscle to date and identify what still remains unknown or poorly investigated in physiological and pathological states, such as training, aging, metabolic disorders and muscular dystrophies. [Expert Rev Proteomics] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSResearchers Receive $1.5 Million Each to Study Extracellular Matrix for Cardiovascular Research Two researchers have been awarded grants that could help uncover the next breakthrough in heart-health research, the American Heart Association and The Paul G. Allen Frontiers Group. [American Heart Association, Inc.] Press Release First FDA-Approved Treatment for ALS in 22 Years Now Available in U.S. Mitsubishi Tanabe Pharma America, Inc., announced RADICAVA™, an intravenous therapy indicated for all adult patients diagnosed with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is available for treatment in the United States. RADICAVA™, the first FDA-approved ALS treatment option in more than 20 years, has been demonstrated to slow the decline in the loss of physical function in ALS patients by 33 percent in its clinical trial. [Mitsubishi Tanabe Pharma America, Inc.] Press Release Mitobridge, Inc. announced a key milestone with the initiation of the first-in-human Phase I trial of its PPAR-delta modulator, MA-0211. [Mitobridge, Inc. (Business Wire Inc.)] Press Release | |
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POLICY NEWSUS Biomedical-Research Facilities Unprepared for Attacks and Natural Disasters When Hurricane Sandy hit New York City in 2012, the storm destroyed scientific equipment worth more than US$20 million at the New York University Langone Medical Center. Tropical Storm Allison hit the University of Texas Health Science Center in Houston in 2001, and caused so much damage that some researchers had to restart their careers elsewhere. Despite such catastrophes, a report found that many research institutions in the United States are still unprepared for disasters. [Nature News] Editorial Americans Are Becoming More Open to Human Genome Editing, Survey Finds, but Concerns Remain Earlier surveys of Americans found a reluctance to support human genome editing, with many respondents expressing ethical and other concerns about such intentional tinkering. A new survey found that two-thirds of the 1600 respondents thought genome editing was generally “acceptable.” But that acceptance was qualified, and colored by religious beliefs and scientific knowledge. [ScienceInsider] Editorial Thousands across India March in Support of Science Thousands of scientists, university students and science enthusiasts gathered in dozens of Indian cities to march in support of science — lamenting their country’s low levels of funding for research, and complaining about government promotion of ‘unscientific ideas’. [Nature News] Editorial
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EVENTSNEW Keystone Symposia: Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Student – Cardiac Stem Cell Differentiation (Ernst Moritz Arndt Universität Greifswald) NEW Scientist – Obesity, Metabolic & Muscle Diseases (Regeneron) Postdoctoral Research Scientist – Duchenne Muscular Dystrophy (University of Oxford) Assistant Professor – Skeletal Muscle Physiology (University of California, Davis) Postdoctoral Fellow – Neuromuscular Diseases and Rare Genetic Diseases (University of Alberta) Postdoctoral Positions – Center for Research on Inflammatory Diseases (The University of Sao Paulo) Postdoctoral Fellow – Diabetes and Heart Disease (University Health Network) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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