Muscle Cell News 2.28 August 21, 2017 | |
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TOP STORYInjectable Tissue Patch Could Help Repair Damaged Organs Repairing heart tissue destroyed by a heart attack or medical condition with regenerative cells or tissues usually requires invasive open-heart surgery. But now biomedical engineering Professor Milica Radisic and her colleagues have developed a technique that lets them use a small needle to inject a repair patch, without the need to open up the chest cavity. [Press release from the University of Toronto discussing online prepublication in Nature Materials] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSScientists describe how to efficiently direct human pluripotent stem cells differentiation into self-renewing epicardial cells in a completely defined, xeno-free system by temporal modulation of regulators of canonical Wnt signaling. [Nat Protoc] Abstract Cardiac Injury of the Newborn Mammalian Heart Accelerates Cardiomyocyte Terminal Differentiation Investigators tested the hypothesis that apical resection either inhibits, delays, or reverses cardiomyocyte centrosome disassembly and binucleation. Consistent with the nearly two-fold increased rate of binucleation there was a nearly two-fold increase in the number of cardiomyocytes in mitosis indicating that the majority of injury-induced cardiomyocyte cell cycle activity results in binucleation, not proliferation. [Sci Rep] Full Article Researchers evaluated the impact of miR-26b during the progression of cardiomyocyte differentiation from the P19 cell line. Overexpression of miR-26b upregulated the expression level of cardiomyocyte-related genes such as Gata4, cTNT, α-MHC and α-Actinin that comprehensively represent cardiomyocyte differentiation by effecting Wnt5a signaling and Gsk3β activity. [Cell Prolif] Abstract The authors investigated the expression patterns and functional roles of the Cited4 gene during in vitro cardiogenesis. Using embryoid bodies formed from mouse embryonic stem cells, they evaluated the expression patterns of the Cited4 gene by quantitative reverse transcriptase-polymerase chain reaction. [PLoS One] Full Article SKELETAL MUSCLE CELLSInvestigators developed a novel approach to enhance the proliferation and differentiation of human skeletal muscle progenitor cells in vitro with skeletal muscle extracellular matrix in combination with a modified alginate hydrogel conjugated with gelatin and heparin as a substrate. [Acta Biomater] Abstract | Graphical Abstract Scientists found that intracellular esterase activity distinguishes a subpopulation of cultured satellite cells with high stemness using esterase-sensitive cell staining reagent, calcein-AM. [Sci Rep] Full Article P2Y6 Regulates Cytoskeleton Reorganization and Cell Migration of C2C12 Myoblasts via ROCK Pathway Researchers examined the role of P2Y6 receptor in C2C12 myoblasts migration. C2C12 myoblasts were treated with P2Y6 agonist UDP, P2Y6 antagonist MRS2578, Ca2+ channel blocker BTP2, or ROCK inhibitor GSK269962 or Y27632, and the migration ability of C2C12 cells was assessed by wound healing assay. [J Cell Biochem] Abstract SMOOTH MUSCLE CELLSThe authors investigated the role of transient receptor potential channel-3 (TRPC3) in acetylcholine (ACh)-induced airway smooth muscle cell (ASMC) proliferation. Primary mouse ASMCs were cultured with or without ACh treatment, then cell viability, TRPC3 expression, nonselective cation channel currents and [Ca2+]i changes were examined by MTT assay, cell counting, Western blotting, standard whole-cell patch clamp recording and calcium imaging, respectively. [Life Sci] Abstract Lactate Dehydrogenase-A Is Indispensable for Vascular Smooth Muscle Cell Proliferation and Migration Scientists investigated the role of lactate dehydrogenase-A in the proliferation and migration of vascular smooth muscle cells (VSMCs). Activation of primary rat VSMCs with fetal bovine serum or platelet-derived growth factor increased their proliferation and migration, glycolytic activity, and expression of lactate dehydrogenase-A. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSRegulation of Human Airway Smooth Muscle Cell Migration and Relevance to Asthma Increased airway smooth muscle mass may be collectively due to airway infiltration of myofibroblasts, neighbouring airway smooth muscle cells in the bundle, or circulating hemopoietic progenitor cells. Researchers discuss the current evidence with respect to the regulation of airway smooth muscle cell migration in asthma. [Respir Res] Full Article Regulation and Phylogeny of Skeletal Muscle Regeneration The authors provide an overview of the some of the main regulatory cellular and molecular players involved in skeletal muscle repair. [Dev Biol] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWS$3.7 Million Grant to Fund Research on Novel Drug Targeting Heart Diseases The Exscien Corporation of Louisville, KY, in conjunction with LSU Health New Orleans Cardiovascular Center of Excellence, has been awarded an SBIR Fast-Track grant in the amount of $3.7 million by the National Heart, Lung and Blood Institute. The funding will be used to study the company’s first in a new class of drugs that repairs DNA damage to reduce cardiac tissue injury and improve outcomes in cardiovascular diseases. [LSU Health Sciences Center New Orleans] Press Release Global Group to Investigate Genetic Causes of Cerebral Palsy A new international research group has been established to investigate the underlying genetic causes of cerebral palsy, spurred on by the discoveries of University of Adelaide researchers. The news comes as the Adelaide team behind the new collaboration has been awarded a $1 million grant to continue its groundbreaking work, from The Tenix and Cerebral Palsy Foundations. [The University of Adelaide] Press Release Alexion Pharmaceuticals, Inc. announced that the European Commission approved the extension of the indication for Soliris® to include the treatment of refractory generalized myasthenia gravis in adults who are anti-acetylcholine receptor antibody-positive. [Alexion Pharmaceuticals, Inc.] Press Release | |
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POLICY NEWSNSF Reiterates Policy on Teaching Good Research Habits despite Its Limitations The National Science Foundation (NSF) in Arlington, Virginia, has decided to double down on its implementation of a congressionally mandated policy aimed at reducing research misconduct among NSF-funded scientists, despite a new report that notes problems with the agency’s approach. [ScienceInsider] Editorial Trump’s First List of Science Priorities Ignores Climate—and Departs from His Own Budget Request President Donald Trump has translated his campaign promise to “make America great again” into his administration’s first blueprint for federal investment in science and technology. [ScienceInsider] Editorial Budget Cuts Fuel Frustration among Japan’s Academics Japan’s premier scientific research institution, RIKEN, turned 100 this year, and celebrated with a grand ceremony attended by the empress and emperor. But not everybody was in the mood to party. In the old days, RIKEN was known as a paradise for scientists because of its generous funding. No longer: as Japan cuts off funds in the face of continuing financial uncertainty, the cracks are starting to show. [Nature News] Editorial
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EVENTSNEW American Society for Cell Biology (ASCB)-European Molecular Biology Organization (EMBO) 2017 Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Muscular Dystrophy (University of Florida) PhD Student – Cardiac Stem Cell Differentiation (Ernst Moritz Arndt Universität Greifswald) Scientist – Obesity, Metabolic & Muscle Diseases (Regeneron) Postdoctoral Research Scientist – Duchenne Muscular Dystrophy (University of Oxford) Assistant Professor – Skeletal Muscle Physiology (University of California, Davis) Postdoctoral Fellow – Neuromuscular Diseases and Rare Genetic Diseases (University of Alberta) Postdoctoral Positions – Center for Research on Inflammatory Diseases (The University of Sao Paulo) Postdoctoral Fellow – Diabetes and Heart Disease (University Health Network) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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