Muscle Cell News 3.08 March 12, 2018 | |
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TOP STORYScientists showed that Van Gogh-like 2 (Vangl2), a core regulator of the non-canonical Wnt/planar cell polarity pathway, affects tumor propagating cell self-renewal in rhabdomyosarcoma-a pediatric cancer of muscle. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSProspective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy Comparative quantitative proteomic analysis of enriched ISL1+ cells identified ALCAM as a surface marker that enabled the isolation of ISL1+ progenitor cells. ALCAM+/ISL1+ progenitors are multipotent and differentiate into cardiomyocytes, endothelial cells, and smooth muscle cells. [Stem Cell Reports] Full Article MiR34 Inhibition Induces Human Heart Progenitor Proliferation The decrease of miR34 expression in the cardiac progenitor cell population indicated its role in maintaining an undifferentiated status and consequently in a lower proliferation rate with the involvement of genes such as Notch-1, Numb, and p63. [Cell Death Dis] Full Article Signature of Circular RNAs in Human Induced Pluripotent Stem Cells and Derived Cardiomyocytes Investigators explored the circular RNA (circRNA) profiles in human induced pluripotent stem cells (hiPSCs) and hiPSC-derived cardiomyocytes, and identified cardiac or disease-specific circRNAs. [Stem Cell Res Ther] Full Article SKELETAL MUSCLE CELLSResearchers demonstrated that miR-16-5p directly targets SESN1 to regulate the p53 signaling pathway, and therefore affecting myoblast proliferation and apoptosis. Additionally, SESN1 targeted myogenic genes to control myoblast differentiation. [Cell Death Dis] Full Article Investigators showed that the majority of small RNAs present in quiescent, activated and differentiated muscle cells belong to the microRNA class. Furthermore, by comparing expression in distinct cell states, they report a massive and dynamic regulation of microRNAs, both in numbers and amplitude, highlighting their pivotal role in regulation of quiescence, activation and differentiation. [Sci Rep] Full Article Muscle Stem Cell Dysfunction Impairs Muscle Regeneration in a Mouse Model of Down Syndrome Impairment of satellite cell function, which further declines as Ts65Dn mice age, underscores stem cell deficiencies as an important contributor to Down syndrome pathologies. [Sci Rep] Full Article SMOOTH MUSCLE CELLSAn HDAC9-MALAT1-BRG1 Complex Mediates Smooth Muscle Dysfunction in Thoracic Aortic Aneurysm Researchers showed that mutations affecting TGF-β signaling and vascular smooth muscle cell cytoskeleton both lead to the formation of a ternary complex comprising the histone deacetylase HDAC9, the chromatin-remodeling enzyme BRG1, and the long noncoding RNA MALAT1. [Nat Commun] Full Article The authors report a novel regulatory axis, phosphatidylinositol 3‐kinase–DNA methyltransferase 1–miR‐1281–histone deacetylase 4, integrating multiple epigenetic regulators that participate in platelet‐derived growth factor BB–stimulated pulmonary artery smooth muscle cell proliferation and migration and pulmonary vascular remodeling. [J Am Heart Assoc] Full Article | |
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REVIEWSPotential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration Based on current in vitro investigations, scientists focus on novel mechanisms linking omega-3 polyunsaturated fatty acids (n-3 PUFAs) to satellite cell activity and how they may improve muscle repair. [Nutrients] Full Article Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSScientists Honored with Kappa Delta Awards for Advancing Orthopaedic Research Four scientists who have made significant contributions to orthopaedic research were honored by the Kappa Delta Foundation and the Orthopaedic Research and Education Foundation. This year’s award winners have made a major impact to research in the areas of tendon healing and remodeling, the use of adult stem cells for musculoskeletal tissue repair, joint degeneration and anterior cruciate ligament reconstruction. [American Academy of Orthopaedic Surgeons (PR Newswire Association LLC.)] Press Release MDA Collaborates with IQVIA to Expand Disease Registry into the New MOVR Data Hub The Muscular Dystrophy Association (MDA) is enhancing and expanding its disease registry into a comprehensive data hub as part of a new initiative with IQVIA, a company known worldwide for its expertise in cutting-edge information management, analytics and technology. [Muscular Dystrophy Association] Press Release | |
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POLICY NEWSKey Republican Lawmaker Releases New ‘Right-to-Try’ Legislation A key Republican lawmaker released a new version of so-called “right to try” legislation, a pivotal next step in the effort to help dying patients get access to experimental therapies. [STAT News] Editorial Scientists Win and Lose in Texas Primary Contests Texas primary was the first test for scientists seeking seats in the U.S. House of Representatives, and the results were mixed. [ScienceInsider] Editorial Behavioral ‘Violations’ Cost Prominent Neuroscientist Positions at Columbia, HHMI Prominent Columbia University neuroscientist Tom Jessell, 66, has been fired for “serious [behavioral] violations” and the university is closing his lab, the New York City institution said in a statement. The Howard Hughes Medical Institute (HHMI) in Chevy Chase, Maryland, which effectively employed Jessell, a leader in understanding neural development, also terminated him as an investigator because he “violated HHMI policy,” according to a statement from the institute. [ScienceInsider] Editorial Police Probe of Brazilian Marijuana Researcher Sparks Protests A police investigation targeting Brazil’s most prominent marijuana researcher has ignited a wave of protest among scientists. They say that the move by authorities from the state of São Paulo threatens research freedoms at a time when science in the country faces severe problems because of draconian budget cuts. [Nature News] Editorial
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EVENTSNEW Gordon Research Conferences: Chemotactic Cytokines Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Assistant – Cardiovascular Medicine (University of Oxford) Director – Whitaker Cardiovascular Institute (Boston University) Postdoctoral Fellowship – Basic and Translational Heart Failure (University of South Florida) Postdoctoral Position – Stem Cell Biology (University of California, Los Angeles) Fellowship – Cardio-Biology (Johns Hopkins University) Postdoctoral Associate – Bioengineering (University of Pittsburgh) Principal Investigator – Cardiology (Boston Children’s Hospital) Postdoctoral Fellow – Metabolic Regulation (Harvard University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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