Muscle Cell News 3.32 September 24, 2018 | |
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TOP STORYResearchers identified cell death by mitotic catastrophe as a cause of impaired stem cell proliferative expansion in aged animals. They discovered that ligand-dependent stimulation of Notch activated p53 in muscle stem cells via inhibition of Mdm2 expression through Hey transcription factors during normal muscle regeneration and that this pathway was impaired in aged animals. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSMosaic serum response factor (SRF) depletion in neonatal cardiomyocytes (CMs) disrupted many aspects of their maturation, including sarcomere expansion, mitochondrial biogenesis, transverse-tubule formation, and cellular hypertrophy. Maintenance of maturity in adult CMs was less dependent on SRF. [Nat Commun] Full Article The authors revealed that extensively junctional SR-associated mitochondrial segments contained a minor portion of Na+/Ca2+ exchanger (NCLX) and lacked Na+-dependent Ca2+ extrusion. In cells with non-polarized MCU complex distribution, upon NCLX overexpression the same given increase in matrix Ca2+ expended more inner membrane potential. [Cell Rep] Full Article | Press Release | Graphical Abstract Connexin 26 Expression in Mammalian Cardiomyocytes Investigators tested the expression of Cx26. This connexin was found in cardiomyocytes, at the level of clusters scattered over the cell cytoplasm but not at the level of the intercalated discs where the other cardiac connexins are usually located. The expression of Cx26 in H9c2 myoblast cells increased when they were differentiated into a cardiac-like phenotype. [Sci Rep] Full Article SKELETAL MUSCLE CELLSScientists demonstrated that the inhibition of components of the canonical NF-κB pathway caused precocious differentiation of cultured satellite cells both ex vivo and in vitro. [J Mol Cell Biol] Abstract The authors confirmed that miR-499 targeted transforming growth factor β receptor 1 (TGFβR1), a known regulator of skeletal myoblast development. They showed that TGFβR1 significantly promoted the differentiation of C2C12 cells and inhibited their proliferation. [J Cell Physiol] Abstract SMOOTH MUSCLE CELLSPolymerase delta-interacting protein 2 (Poldip2) expression was observed in the intima and media of human atherosclerotic arteries, where it colocalized with proliferating cell nuclear antigen (PCNA). Downregulation of Poldip2 in rat aortic smooth muscle cells significantly reduced serum-induced proliferation and PCNA expression, but upregulated p21 expression. [Lab Invest] Abstract Researchers contrasted cytoskeletal reorganization, epigenetic reprogramming, signaling transduction, and changes in miRNA profiles in primary human aortic smooth muscle cells between unstressed cells and cells exposed to shear stress. [J Cell Physiol] Abstract In cultured vascular smooth muscle cells (VSMCs), phosphoinositide 3-kinases γ (PI3Kγ) blockade with pharmacological inhibitor or genetic knockdown markedly abrogated TNF-α-induced downregulation of VSMC contractile genes and increase in cellular proliferation and migration. [EBioMedicine] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & ESC & iPSC News. | |
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REVIEWSTGFβ, Smooth Muscle Cells and Coronary Artery Disease: A Review The authors present an overview of transforming growth factor-beta (TGFβ) signaling in vascular smooth muscle cell (SMCs), highlighting the ways in which this multifaceted cytokine regulates SMC behaviour and phenotype in cardiovascular diseases driven by intimal hyperplasia. [Cell Signal] Abstract Estrogen in Vascular Smooth Muscle Cells: A Friend or a Foe? Investigators review the conflicting effects of estrogen on vascular smooth muscle cells, mainly proliferation and migration as two cellular capacities intimately related to physiology and pathophysiology of the cardiovascular system. They critically discuss the major parameters and signaling pathways that may account for the aforementioned paradoxical observations, as well as the key molecular players involved. [Vascul Pharmacol] Abstract | Graphical Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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SCIENCE NEWSCatabasis Pharmaceuticals, Inc. announced that the company will share three presentations, including in the late breaking session. [Press release from Catabasis Pharmaceuticals, Inc. discussing research to be presented at the 23rd International Congress of the World Muscle Society, Argentina] Press Release | |
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INDUSTRY NEWSFSD Pharma and SciCann Therapeutics Launch Cardiovascular Research Program in Tel Aviv University SD Pharma Inc. announced the launch of a comprehensive sponsored research program in Tel Aviv University together with its strategic R&D partner, SciCann Therapeutics Inc., focused on the cardiovascular disease field. [FSD Pharma Inc. (PR Newswire Association LLC.)] Press Release GTx, Inc. announced that the ASTRID Trial, a Phase II double-blind, placebo-controlled clinical trial of orally-administered enobosarm in post-menopausal women with stress urinary incontinence, did not achieve statistical significance on the primary endpoint of the proportion of patients with a greater than 50% reduction in incontinence episodes per day compared to placebo. [GTx, Inc.] Press Release Cardurion Pharmaceuticals announced that the U.S. FDA has accepted its Investigational New Drug Application for CRD-733, a Phosphodiesterase-9 (PDE-9) inhibitor in development to improve cardiac function in heart failure patients. [Cardurion Pharmaceuticals] Press Release Sarepta Therapeutics, Inc. announced that the FDA has lifted the clinical hold for the company’s Duchenne muscular dystrophy (DMD) micro-dystrophin gene therapy program. [Sarepta Therapeutics] Press Release Case Western Reserve University School of Medicine has received a three-year, $1,118,556 grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) to investigate a new imaging approach for diagnosing peripheral arterial disease, a common and potentially serious circulatory problem. [Case Western Reserve University] Press Release Coalition to Cure Calpain 3 Provides Gene Therapy Initiative Updates Coalition to Cure Calpain 3 (C3) announced updates to its Gene Therapy Initiative. C3 recently funded two new research grants to explore the potential of gene therapy for limb-girdle muscular dystrophy type 2A/calpainopathy. [Coalition to Cure Calpain 3] Press Release | |
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POLICY NEWSResearchers Take Action to End Airlines’ Restrictions on Lab Animals In a recently filed complaint to the US Department of Transportation, the National Association for Biomedical Research accuses four major airlines of illegally discriminating against customers wishing to fly animals destined for the lab. [The Scientist] Editorial More and More Scientists Are Preregistering Their Studies. Should You? Preregistration, in its simplest form, is a one-page document answering basic questions such as: What question will be studied? What is the hypothesis? What data will be collected, and how will they be analyzed? In its most rigorous form, a “registered report,” researchers write an entire paper, minus the results and discussion, and submit it for peer review at a journal, which decides whether to accept it in principle. [ScienceInsider] Editorial
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EVENTSNEW 6th World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases (BMJD) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Fellow – Cardiac Regeneration & Heart Failure (Icahn School of Medicine at Mount Sinai) Faculty Positions – Cardiovascular Research (Nationwide Children’s Hospital Research Institute) Postdoctoral Fellow – Cardiovascular Biology (Weill Cornell Medicine) Postdoctoral Fellows – Cardiac & Skeletal Muscle Research (Duke University) Scientist – Cardiovascular Research (University of Iowas Hospital and Clinics) Postdoctoral Fellow – Cardiovascular Tissue Engineering (Stanford University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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