Muscle Cell News 3.40 December 3, 2018 | |
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TOP STORYResearchers showed that the immunoglobulin superfamily containing leucine-rich repeat (Islr), a newly identified marker for mesenchymal stem cells, stabilizes canonical Wnt signaling and promote skeletal muscle regeneration. Loss of Islr delayed skeletal muscle regeneration in adult mice. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSHuman induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a powerful tool for human disease modeling and therapeutic testing. However, their use remains limited by their immaturity and heterogeneity. To characterize the source of this heterogeneity, scientists applied complementary single-cell RNA-seq and bulk RNA-seq technologies over time during hiPSC cardiac differentiation and in the adult heart. [Nat Commun] Full Article | Press Release The authors found that miR‐181a could inhibit the apoptosis of hypoxic‐reoxygenated cardiomyocytes by targeting XIAP to downregulate Bax and upregulate Bcl expression. [J Cell Biochem] Abstract mir‐203 Accelerates Apoptosis and Inflammation Induced by LPS via Targeting NFIL3 in Cardiomyocytes Researchers explored the roles and potential mechanisms of miR‐203 in myocarditis in vitro. Cardiomyocyte H9c2 was subjected to 10 μg/mL lipopolysaccharide (LPS) for 24 hours. Real‐time polymerase chain reaction analysis revealed that LPS upregulated miR‐203 expression in H9c2 cells. [J Cell Biochem] Abstract Scientists investigated the role of GUCY1B3 in cardiomyocyte ischemia and reperfusion injury and myocardial infarction in vitro and in vivo. [J Cell Biochem] Abstract SKELETAL MUSCLE CELLSMyotubes from athletic subjects showed lower fatty acid (FA) accumulation, lower incorporation of FA into total lipids, triacylglycerol (TAG), diacylglycerol and cholesteryl ester, higher TAG-related lipolysis and re-esterification, and higher complete oxidation and incomplete β-oxidation of FA compared to myotubes from sedentary subjects. [Sci Rep] Full Article Knockdown of coactivator-associated arginine methyltransferase 1 (CARM1) repressed the progression of muscle wasting and the expression of the atrophy-related genes Atrogin-1 and MuRF1 in vivo and in vitro. [Exp Cell Res] Abstract | Graphical Abstract SMOOTH MUSCLE CELLSIsolation and Culture of Vascular Smooth Muscle Cells from Rat Placenta The authors developed a new separation method for isolating placental vascular smooth muscle cells (PVSMCs) from a rat. Their method used the magnetic force between a magnet and ferrous ferric oxide to make the separation and extraction processes easier and more efficient. [J Cell Physiol] Abstract Researchers report a method for the scalable manufacturing of vascular smooth muscle cells (VSMCs) from human pluripotent stem cells (hPSCs). hPSCs were expanded and differentiated into VSMCs in a 3D thermoreversible hydrogel. [Biomater Sci] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & ESC & iPSC News. | |
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REVIEWSBig Bottlenecks in Cardiovascular Tissue Engineering The authors discuss important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges. [Commun Biol] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSALS Organizations Collaborate to Advance New Therapeutic into Trials Several ALS organizations announced that the first participant was successfully given a dose of AT-1501 in the first in-human trial of the potential treatment for ALS. [ALS ONE] Press Release Pioneering Personalised Heart Models Could Improve Cardiac Care With funding from the Engineering and Physical Sciences Research Council and in collaboration with St Thomas’ Hospital, a team at King’s College London has taken the first steps in developing models designed to optimise a procedure that corrects atrial fibrillation, a condition which causes abnormal heart rhythms. [Engineering and Physical Sciences Research Council] Press Release FDA Approves First Treatment for Lambert-Eaton Myasthenic Syndrome, a Rare Autoimmune Disorder FDA approved Firdapse tablets for the treatment of Lambert-Eaton myasthenic syndrome (LEMS) in adults. LEMS is a rare autoimmune disorder that affects the connection between nerves and muscles and causes weakness and other symptoms in affected patients. [The U.S. Food and Drug Administration] Press Release Novartis announced that the FDA has accepted the company’s Biologics License Application for AVXS-101, now known as ZOLGENSMA®, an investigational gene replacement therapy for the treatment of spinal muscular atrophy (SMA) Type 1. [Novartis] Press Release | |
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POLICY NEWSRomania Cuts Research Budget for Second Time This Year The Romanian government has sliced off another €49 million from its research budget, as the ministry for research and innovation failed to put out funding calls to spend all of the €350 million it had allocated for 2018. [Science|Business] Editorial Biomedical Research Is Becoming More Open about Its Funding and Data Biomedical research is shifting to become more open and transparent by providing increasing amounts of information about funding, conflicts of interest and data sharing in their publications, according to a survey of recent papers. [Nature News] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR) 2019 Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Sarcopenia (Lee Kong Chian School of Medicine) Assistant Professor – Skeletal Muscle Biology (University of Alabama at Birmingham) Tenure Track Assistant Professor – Muscle Biology (University of Zurich) Assistant/Associate Adjunct Professor – Cardiovascular Medicine (UC Davis) Postdoctoral Research Fellow – Cardiac RNA Biology (University of Illinois at Chicago) Postdoctoral Position – Cardiac Hypertrophy & Heart Failure (Masonic Medical Research Laboratory) Postdoctoral Fellow – Muscle Degeneration (Rice University) Assistant/Associate Professor – Exercise Science (Syracuse University) Postdoctoral Research Scientist – Integrative Cardiac Pathophysiology (Columbia University) Postdoctoral Associate Specialist – Muscle Aging Biology (Nestle Research – EPFL Campus) Postdoctoral Fellow – Cardiovascular Tissue Engineering (Stanford University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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