Muscle Cell News Volume 4.09 | Mar 18 2019

TOP STORY

Stem Cell-Derived Cardiomyocyte Tool Could Improve Drug Safety

Researchers developed a tool to isolate specific subpopulations of cardiovascular cells to provide a model for more precise drug testing. [Press release from Stanford Medicine discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

CARDIAC MUSCLE CELLS

Human Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Breast Cancer Patients

The authors assessed the effects of trastuzumab on structural and functional properties in induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from healthy individuals and performed RNA-sequencing to further examine the effect of trastuzumab on iPSC-CMs. [Circulation] Abstract

RBFox2-miR-34a-Jph2 Axis Contributes to Cardiac Decompensation during Heart Failure

Investigators report a regulatory pathway consisting of the RNA binding protein RBFox2, a stress-induced microRNA miR-34a, and the essential excitation-contraction coupler JPH2. [Proc Natl Acad Sci USA] Abstract

Definition of a Cell Surface Signature for Human Cardiac Progenitor Cells after Comprehensive Comparative Transcriptomic and Proteomic Characterization

Assisted by complementary RNAseq analysis, researchers defined the fraction of the cardiac progenitor cell proteome associable with specific functions by comparison with human bone marrow mesenchymal stem cells, the reference population for cell therapy, and human dermal fibroblasts, as a distant reference. [Sci Rep] Full Article

The Intracellular Ca²⁺ Concentration Is Elevated in Cardiomyocytes Differentiated from hiPSCs Derived from a Duchenne Muscular Dystrophy Patient

The authors examined the intracellular Ca²⁺ concentration and calcium transients in cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs). hiPSCs were derived from a Duchenne muscular dystrophy patient, in whom exon 44 of the gene encoding dystrophin was deleted, and from his parents, who did not carry this mutation. [PLoS One] Full Article

SKELETAL MUSCLE CELLS

Oscillations of MyoD and Hes1 Proteins Regulate the Maintenance of Activated Muscle Stem Cells

Scientists demonstrate that the transcriptional regulator Hes1 controls the balance between proliferation and differentiation of activated muscle stem cells in both developing and regenerating muscle. [Genes Dev] Full Article | Press Release

SUMOylation of G9a Regulates Its Function as an Activator of Myoblast Proliferation

The authors report that endogenous G9a is SUMOylated in proliferating skeletal myoblasts. There are four potential SUMOylation consensus motifs in G9a. Mutation of all four acceptor lysine residues inhibited SUMOylation. [Cell Death Dis] Full Article

The Nuclear Receptor and Clock Repressor Rev-erbα Suppresses Myogenesis

Scientists showed that Rev-erbα exerted cell-autonomous inhibitory effects on proliferation and differentiation of myogenic precursor cells, and these actions concertedly inhibited muscle regeneration in vivo. [Sci Rep] Full Article

SMOOTH MUSCLE CELLS

A Microphysiological Model of the Bronchial Airways Reveals the Interplay of Mechanical and Biochemical Signals in Bronchospasm

Investigators showed that a mechanical stimulus mimicking a bronchospastic challenge triggers the marked contraction and delayed relaxation of airway smooth muscle, and that this was mediated by the discordant expression of cyclooxygenase genes in epithelial cells and regulated by the mechanosensor and transcriptional co-activator Yes-associated protein. [Nat Biomed Eng] Abstract

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Cell Therapy to Improve Regeneration of Skeletal Muscle Injuries

Recent improvements in the understanding of cell behavior and the mechanistic basis for their modes of action have led to a new paradigm in cell therapies where physical, chemical, and signaling cues presented through biomaterials can instruct cells and enhance their regenerative capacity. [J Cachexia Sarcopenia Muscle] Full Article

Visit our reviews page to see a complete list of reviews in the muscle cell research field.

GeNeuro’s ANGEL-MS Phase IIb Extension Study Confirms and Extends the Neuroprotective Effects of Temelimab in MS

GeNeuro announced positive results from the ANGEL-MS study of its lead product, temelimab in multiple sclerosis (MS). [GeNeuro] Press Release

Celgene Submits Application to EMA for Ozanimod for the Treatment of Relapsing-Remitting Multiple Sclerosis

Celgene Corporation announced that the company has submitted a Marketing Authorization Application to the European Medicines Agency (EMA) for ozanimod for the treatment of adults with relapsing-remitting multiple sclerosis. [Celgene Corporation] Press Release

Survey Highlights “Shocking” Gender Bias Among PI Pay in UK

Organizers of a survey of early-career scientists in the UK say they are shocked by the picture it paints of gender bias in British science. Women principal investigators (PIs) who have started their own lab in recent years are paid thousands of pounds a year less than men at the same stage of their career, the results show. [The Scientist] Editorial

Norway Joins List of Countries Canceling Elsevier Contracts

Norway has become latest country to cancel its contracts with Elsevier following a dispute over access to research papers. In a statement published March 12, the Norwegian Directorate for ICT and Joint Services in Higher Education and Research, which represents a consortium of research institutions in the country, rejected Elsevier’s offer to lower some of its costs for Norwegian institutions because it didn’t go far enough to promote free access to published research. [The Scientist] Editorial

NEW Advanced Cell Therapies and Tissue Engineering
November 14-16, 2019
Milan, Italy

Visit our events page to see a complete list of events in the community.

NEW Early Stage Researchers – Various (Institutions across Europe in the TRIM-NET – ITN Network)

Postdoctoral Research Associate – Cardiovascular Research (Old Dominion University)

Postdoctoral Position – Mechanotransduction in Heart Development and Regeneration (Brown University)

Assistant Professor – Sarcoma or Skeletal Related Malignancies (University of California, Davis)

Postdoctoral Position – Muscle Stem Cell Biology (University of Sherbrooke)

Postdoctoral Fellow – Stem Cells & Cardiac Regeneration (Temple University)

Assistant Specialist – Cardiovascular Research (University of California, Davis)

Postdoctoral Research Associate – Cardiac Stem Cells (University of Louisville)

Postdoctoral Position – Cardiomyopathy (University of Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute)

Clinical Tenure Track/Tenure-Eligible Investigator – Cardiology (National Heart, Lung and Blood Institute)

Postdoctoral Research Position – Cardiovascular Medicine (University of California, Davis)

Assistant/Associate Adjunct Professor – Cardiovascular Medicine (University of California Davis)

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