Muscle Cell News Volume 5.24 | Jul 6 2020

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    MUSCN 5.24 | Jul 6


    Muscle Cell News by STEMCELL Technologies
    Vol. 5.24 – 06 July, 2020
    TOP STORY

    Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy

    Primary adult rat ventricular myocytes were studied for morphology and intracellular signaling. Cardiac myocyte-specific CIP4 gene deletion in mice attenuated pressure overload-induced pathological cardiac remodeling and heart failure.
    [Circulation]

    Abstract

    51078b28-8a06-404f-a411-23c10ab9c25e_ON678MSC-STEMdiff-Cardiomyocyte-645x110-For_CXN
    PUBLICATIONSRanked by the impact factor of the journal

    Intrinsic Color Sensing System Allows for Real-Time Observable Functional Changes on Human Induced Pluripotent Stem Cell Derived Cardiomyocytes

    Scientists developed an intrinsic color sensing system utilizing a microgroove structural color methacrylated gelatin film, which allowed them to monitor the cardiac differentiation process of hiPSC-derived cardiac progenitor cells in real time.
    [ACS Nano]

    Abstract

    Induced Pluripotent Stem Cells of Patients with Tetralogy of Fallot Reveal Transcriptional Alterations in Cardiomyocyte Differentiation

    Induced pluripotent stem cells were generated and further differentiated to cardiomyocytes using standard methods from two well-characterized Tetralogy of Fallot patients and their healthy relatives serving as controls.
    [Scientific Reports]

    Full Article

    Human iPSC-Derived Cardiomyocytes are Susceptible to SARS-CoV-2 Infection

    Investigators utilized human induced pluripotent stem cell-derived cardiomyocytes as a model to examine the mechanisms of cardiomyocyte-specific infection by SARS-CoV-2.
    [Cell Reports Medicine]

    AbstractFull ArticleGraphical Abstract

    GJA1-20k Attenuates Ang II-Induced Pathological Cardiac Hypertrophy by Regulating Gap Junction Formation and Mitochondrial Function

    In neonatal rat cardiomyocytes, overexpression of GJA1-20k attenuated Ang II-induced cardiomyocyte hypertrophy and caused elevated levels of gap junction coupling at the cell-cell borders.
    [Acta Pharmacologica Sinica]

    Abstract

    Irradiation Dependent Inflammatory Response May Enhance Satellite Cell Engraftment

    Scientists found no difference in the percentage of dying cells in immunodeficient dystrophic mouse muscles at the times after the irradiation dose that enhanced donor cell engraftment.
    [Scientific Reports]

    Full Article

    A Reference Single-Cell Transcriptomic Atlas of Human Skeletal Muscle Tissue Reveals Bifurcated Muscle Stem Cell Populations

    Differential expression analysis identified transcriptional profiles altered in the activated muscle stem/progenitor cells including genes associated with aging, obesity, diabetes, and impaired muscle regeneration, as well as long non-coding RNAs previously undescribed in human myogenic cells.
    [Skeletal Muscle]

    Full Article

    Novel Airway Smooth Muscle-Mast Cell Interactions and a Role for the TRPV4-ATP Axis in Non-Atopic Asthma

    Trypsin was shown to evoke contraction of tracheal tissue via activation of PAR-2-TRPV4-ATP-cysLT axis indicating the potential disease relevance of this signaling pathway.
    [European Respiratory Journal]

    Full Article

    Distinctive Roles of Abi1 in Regulating Actin-Associated Proteinsd during Human Smooth Muscle Cell Migration

    Abelson interactor 1 (Abi1) knockdown by shRNA reduced human airway smooth muscle cell migration, which was restored by Abi1 rescue. Abi1 localized at the tip of lamellipodia and its protrusion coordinated with F-actin at the leading cell edge of live cells.
    [Scientific Reports]

    Full Article

    Cytokine Regulation of Apoptosis-Induced Apoptosis and Apoptosis-Induced Cell Proliferation in Vascular Smooth Muscle Cells

    Vascular smooth muscle cells (VSMCs) undergoing apoptosis through Fas/CD95 or the protein kinase inhibitor staurosporine transcriptionally activated interleukin 6 and granulocyte-macrophage colony stimulating factor, leading to their secretion.
    [Apoptosis]

    Full Article

    a6b79c2b-118d-4b2b-a71e-6239c561b622_ON810MYO-MyoCult
    REVIEWS

    Exercise Adaptations: Molecular Mechanisms and Potential Targets for Therapeutic Benefit

    The authors provide an overview of the beneficial adaptive responses to exercise and detail the molecular mechanisms involved. The possibility of designing therapeutic interventions based on these molecular mechanisms is addressed, using relevant examples that have exploited this approach.
    [Nature Reviews Endocrinology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Sarepta Therapeutics Signs Agreement with Hansa Biopharma for Imlifidase

    Sarepta Therapeutics, Inc. announced an agreement with Hansa Biopharma, the leader in immunomodulatory enzyme technology for rare Immunoglobulin G mediated diseases, for imlifidase.
    [Sarepta Therapeutics]

    Press Release

    Initiative Recruits Scientist-Volunteers to Aid COVID-19 Research

    In mid-March, as businesses and universities across Europe were shutting down in a bid to slow the COVID-19 pandemic, three longtime friends were talking about how they wished they could do something to combat the disease.
    [The Scientist]

    Editorial

    FEATURED EVENT

    2020 Parenteral Drug Association (PDA) Virtual Pharmaceutical Manufacturing Data Science Workshop

    July 13 – July 16
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoc Position – Cardiovascular Research

    Albert Einstein College of Medicine – Bronx, New York, United States

    PhD Student – Musculoskeletal Diseases

    University Hospital of Muenster – Muenster, Germany

    Postdoctoral Researcher/Surgery – Muscle Fibrosis

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Fellow – Aging Muscle

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Assistant Specialist – Cardiovascular Medicine

    University of California, Davis – Davis, California, United States

    Postdoctoral Position – Muscle Function

    Spanish National Center for Cardiovascular Research – Madrid, Spain

    > See All Jobs

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