 | | Vol. 5.32 – 14 September, 2020 |
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| Investigators developed an in vitro disease-in-a-dish model using iPSCs from type 2 diabetes (T2D) patients differentiated into myoblasts (iMyos). They found that T2D iMyos in culture exhibited multiple defects mirroring human disease, including an altered insulin signaling, decreased insulin-stimulated glucose uptake, and reduced mitochondrial oxidation.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators knocked out the main de novo DNA methyltransferase in cardiomyocytes, DNMT3A, in human (h)iPSCs. Functional consequences of DNA methylation-deficiency under control and stress conditions were then assessed in human engineered heart tissue from knockout hiPSC-derived cardiomyocytes.
[Circulation] |
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| Scientists cross-referenced differentially-expressed proteins with their differentially-expressed genes from single-cell transcriptomes of non-myocyte cardiac cells isolated from a murine myocardial infarction model.
[Circulation] |
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| With age, expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) was increased in the pulmonary alveolar epithelial barrier, cardiomyocytes, and vascular endothelial cells.
[Cell Research] |
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| Researchers developed a method to generate heart organoids from mouse embryonic stem cell-derived embryoid bodies.
[Nature Communications] |
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| Scientists investigated protective effects of canagliflozin in isoprenaline-induced cardiac oxidative stress, and their underlying molecular mechanisms in Long-Evans rat heart and in HL-1 cardiomyocyte cell lines.
[Scientific Reports] |
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| The authors demonstrated that loss of Z-disc-anchored TTN recapitulates muscle remodeling in critical illness ‘myosinopathy’ patients, characterized by TTN-depletion and loss of thick filaments.
[Nature Communications] |
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| Researchers investigated whether damaged myofibers influence the activation of satellite cells. They revealed that satellite cells were directly activated by damaged-myofiber-derived factors.
[Stem Cell Reports] |
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| Muscle wasting pathway proteins were upregulated while those that promote growth decreased as did mitochondrial endpoints and muscle ATP levels.
[Scientific Reports] |
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| Scientists focused on defining extensive physical changes in chromatin organization in the process of skeletal myoblast differentiation.
[Scientific Reports] |
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| Researchers demonstrated that chronic mTORC1 inhibition with rapamycin was overwhelmingly, but not entirely, positive for aging mouse skeletal muscle, while genetic, muscle fiber-specific activation of mTORC1 was sufficient to induce molecular signatures of sarcopenia.
[Nature Communications] |
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| Investigatiors found that smooth muscle cells (SMCs) and SMC-conditioned media stimulated migration and invasion of an extravillous trophoblasts-like cell line, HTR8/SVneo.
[Molecular Human Reproduction] |
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| The authors discuss the various concepts of heart valve tissue engineering underlying the design of next-generation tissue-engineered heart valves, focusing on off-the-shelf technologies.
[Nature Reviews Cardiology] |
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| Scientists consider the biology of the neuromuscular junction (NMJ) and review emerging lines of investigation that are highlighting the importance of cell-cell interaction at the NMJ in spinal muscular atrophy, X-linked spinal and bulbar muscular atrophy, and amyotrophic lateral sclerosis.
[Trends in Neurosciences] |
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| Researchers summarize current knowledge on the critical role of Drp1 in the pathogenesis of CVDs including endothelial dysfunction, smooth muscle remodeling, cardiac hypertrophy, pulmonary arterial hypertension, myocardial ischemia–reperfusion, and myocardial infarction.
[Acta Pharmacologica Sinica] |
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| Rocket Pharmaceuticals, Inc. announced it has treated the first patient in the higher dose cohort in its open-label, Phase I clinical trial of RP-A501, the Company’s adeno-associated viral vector-based gene therapy for the treatment of Danon Disease.
[Rocket Pharmaceuticals, Inc.] |
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| | Swiss Federal Institute of Technology Zurich – Zürich, Switzerland |
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| | Duke University – Durham, North Carolina, United States |
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| | University of California, Davis – Davis, California, United States |
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| | University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States |
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| | UPMC Children’s Hospital of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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