Muscle Cell News Volume 5.39 | Nov 9 2020

May 12, 2022

2020-09-11 | MUSCN 5.39

Muscle Cell News by STEMCELL Technologies

Vol. 5.39 – 9 November, 2020

TOP STORY

Loss
of Endogenously Cycling Adult Cardiomyocytes Worsens Myocardial Function

The ablation of endogenously cycling adult cardiomyocytes in αDKRC::DTA mice caused progressive worsening left ventricular chamber size and function after ischemic-reperfusion myocardial infarction, compared to controls.
[Circulation Research]

Abstract

Generate functional cardiomyocytes from hPSCs with the STEMdiff™ Cardiomyocyte Differentiation Kit

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

Dystrophin
Gene Editing Stability Is Dependent on Dystrophin Levels in Skeletal but not Cardiac Muscles

Investigators explored the persistence of dystrophin expression following rAAV6:CRISPR/Cas9-mediated multi-exon deletion/reframing in systemically injected 2- and 11-week old dystrophic mice, and showed that induction of low dystrophin levels persisted for several months in cardiomyocytes, but not in skeletal muscles, where myofibers remained susceptible to necrosis and regeneration.
[Molecular Therapy]

Abstract Graphical Abstract

Membrane
Nanotubes Facilitate the Propagation of Inflammatory Injury in the Heart upon Overactivation of the β-Adrenergic Receptor

β-adrenergic receptor (β-AR) overactivation induced inflammasome activation in both the cardiomyocytes and cardiac fibroblasts of mice hearts following a subcutaneous injection of isoproterenol, a selective agonist of β-AR.
[Cell Death & Disease]

Full Article

Activation
of Toll Like Receptor 4 (TLR4) Promotes Cardiomyocyte Apoptosis through SIRT2 Dependent p53 Deacetylation

Scientists attempted to find the role of TLR4 in cardiac fibrosis and apoptosis, and molecular mechanism thereof. Myocardial oxidative stress, inflammation, fibrosis and mitochondrial parameters were evaluated both in vitro and in vivo.
[Scientific Reports]

Full Article

Human
Perinatal Stem Cell Derived Extracellular Matrix Enables Rapid Maturation of hiPSC-CM Structural and Functional Phenotypes

Researchers tested the hypothesis that human perinatal stem cell derived extracellular matrix (ECM) promotes human induced pluripotent stem cell derived cardiomyocyte maturation to a greater extent than mouse cell derived ECM.
[Scientific Reports]

Full Article

SKELETAL MUSCLE CELLS

FABP3-Mediated
Membrane Lipid Saturation Alters Fluidity and Induces ER Stress in Skeletal Muscle with Aging

Investigators report that FABP3 was upregulated in aged skeletal muscles, disrupting homeostasis via lipid remodeling. Lipidomic analyses revealed that FABP3 overexpression in young muscles altered the membrane lipid composition to that of aged muscle by decreasing polyunsaturated phospholipid acyl chains, while increasing sphingomyelin and lysophosphatidylcholine.
[Nature Communications]

Full Article

Intravital
Imaging Reveals Cell Cycle-Dependent Myogenic Cell Migration during Muscle Regeneration

Researchers found that in vivo, extracellular signal-regulated kinase was maximally activated in myogenic cells two days after injury, and this was then followed by increases in cell number and motility.
[Cell Cycle]

Abstract

Dead
Muscle Tissue Promotes Dystrophic Calcification by Lowering Circulating TGF-β1 Level

Scientists demonstrated that suppression of transforming growth factor-beta (TGF-β) signaling promoted dystrophic calcification in vivo, and potentiated osteogenic differentiation of muscle-derived stromal cells in vitro.
[Bone & Joint Research]

Full Article

CARM1 Regulates AMPK Signaling in Skeletal Muscle

Coactivator-associated arginine methyltransferase 1 (CARM1) skeletal muscle-specific knockout mice displayed reduced muscle mass and dysregulated autophagic and atrophic processes downstream of AMP-activated protein kinase (AMPK).
[iScience]

Abstract Graphical Abstract

SMOOTH MUSCLE CELLS

Spermine Promotes Pulmonary Vascular Remodelling and Its Synthase Is a Therapeutic Target for Pulmonary Arterial Hypertension

The roles of spermine and spermine synthase were examined in pulmonary arterial smooth muscle cells and rodent models of pulmonary hypertension.
[European Respiratory Journal]

Abstract

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REVIEWS

The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease

The authors highlight some of the findings on the multifaceted functions of cullin-RING E3-ligases, their substrate adapters, muscle protein substrates, and regulatory proteins, such as the Cop9 signalosome, for the development of cross striated muscles, and their roles in the etiology of myopathies.
[International Journal of Molecular Sciences]

Full Article

INDUSTRY AND POLICY NEWS

FDA Grants Rare Pediatric Disease Designation to AMO Pharma for AMO-02 for Treatment of Congenital Myotonic Dystrophy

AMO Pharma Limited announced that the FDA has granted a Rare Pediatric Disease designation to AMO-Pharma for AMO-02, the company’s investigational therapy in development for the treatment of congenital myotonic dystrophy.
[AMO Pharma Limited (PR Newswire Association LLC.)]

Press Release

Sarepta Therapeutics to Commence Dosing of the Next Study with Commercial Process Material for the SRP-9001 Gene Therapy Program for the Treatment of Duchenne Muscular Dystrophy

Sarepta Therapeutics, Inc. announced important updates related to the development plan for SRP-9001, the company’s investigational gene transfer therapy for the treatment of Duchenne muscular dystrophy.
[Sarepta Therapeutics, Inc.]

Press Release

FEATURED EVENT

Loss
of Endogenously Cycling Adult Cardiomyocytes Worsens Myocardial Function

Dystrophin
Gene Editing Stability Is Dependent on Dystrophin Levels in Skeletal but not Cardiac Muscles

Membrane
Nanotubes Facilitate the Propagation of Inflammatory Injury in the Heart upon Overactivation of the β-Adrenergic Receptor

Activation
of Toll Like Receptor 4 (TLR4) Promotes Cardiomyocyte Apoptosis through SIRT2 Dependent p53 Deacetylation

Human
Perinatal Stem Cell Derived Extracellular Matrix Enables Rapid Maturation of hiPSC-CM Structural and Functional Phenotypes

FABP3-Mediated
Membrane Lipid Saturation Alters Fluidity and Induces ER Stress in Skeletal Muscle with Aging

Intravital
Imaging Reveals Cell Cycle-Dependent Myogenic Cell Migration during Muscle Regeneration

Dead
Muscle Tissue Promotes Dystrophic Calcification by Lowering Circulating TGF-β1 Level

CARM1 Regulates AMPK Signaling in Skeletal Muscle

Spermine Promotes Pulmonary Vascular Remodelling and Its Synthase Is a Therapeutic Target for Pulmonary Arterial Hypertension

The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease

FDA Grants Rare Pediatric Disease Designation to AMO Pharma for AMO-02 for Treatment of Congenital Myotonic Dystrophy

Sarepta Therapeutics to Commence Dosing of the Next Study with Commercial Process Material for the SRP-9001 Gene Therapy Program for the Treatment of Duchenne Muscular Dystrophy

2021 Muscular Dystrophy Association (MDA) Clinical and Scientific Conference

> See All Events

Faculty
Member – Bacaner Endowed Chair in Physiology

Postdoctoral Fellow – Cardiovascular Development and Regeneration

Staff
Scientist – Heart Disease Molecular Mechanisms

Postdoctoral Research Fellow Position – Urinary Physiology

Postdoctoral Fellow – Computational Systems Biology/Bioinformatics

Faculty
Position – Cytoskeleton, Molecular Motors or Contractile Systems

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