 | | Vol. 5.42 – 30 November, 2020 |
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| Investigators generated muscle stem cell‐specific androgen receptor and estrogen receptor 2 double knockout mice and pharmacologically inhibited the hypothalamic–pituitary–gonadal axis to mimic decreased serum levels of sex steroid hormones in aged mice.
[Journal of Cachexia Sarcopenia and Muscle] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that protein levels of the Bromodomain and extra-terminal domain (BET) protein BRD4 were significantly increased in the muscle of the mouse model of Duchenne muscular dystrophy, the mdx mouse, and that pharmacological inhibition of the BET proteins had a beneficial outcome, tempering oxidative stress and muscle damage.
[Nature Communications] |
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| Researchers analyzed a new type of oscillation called hyperthermal sarcomeric oscillation. Sarcomeres in rat neonatal cardiomyocytes that were warmed at 38–42 °C oscillated at both slow, Ca2+-dependent frequencies and fast, Ca2+-independent frequencies.
[Scientific Reports] |
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| The authors investigated the role and the underlying regulatory mechanism of ubiquitin specific peptidase 7 (USP7) in myocardial infarction.
[APMIS] |
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| Researchers identified nine distinct major clusters including myeloid‐derived cells, fibroblast/fibro/adipogenic progenitors, and skeletal muscle stem cells in glycerol‐injured skeletal muscle.
[Journal of Cachexia Sarcopenia and Muscle] |
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| The authors observed altered interactions between coactivator-associated arginine methyltransferase 1 (CARM1) and AMP-activated protein kinase (AMPK) and its network, including forkhead box protein O1, during muscle disuse.
[iScience] |
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| Osthole inhibited phosphodiesterase 4D activity to amplify autocrine prostaglandin E2 signaling in airway smooth muscle cells that eventually triggered cAMP/PKA-dependent relaxation of airways.
[Science Signaling] |
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| Investigators found abundant transient receptor potential channel M2 (TRPM2) expression in lysosomes/autolysosomes in the primary cultured mouse aortic smooth muscle cells.
[Scientific Reports] |
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| The authors demonstrated that the Hippo pathway effectors YAP and TAZ play a critical role in maintaining the differentiated contractile phenotype of vascular smooth muscle cells.
[iScience] |
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| Scientists discuss recent findings of miR‐128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.
[Journal of Cellular Physiology] |
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| April 27 – April 29, 2021
Wuxi, China |
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| | National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States |
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| | Imperial College London – London, England, United Kingdom |
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| | Stanford University – Stanford, California, United States |
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| | University of Minnesota Medical School – Minneapolis, Minnesota, United States |
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| | Novo Nordisk A/S – Copenhagen, Denmark |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, China |
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