 | | Vol. 6.02 – 18 January, 2021 |
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| Researchers developed a workflow enabling proteomics analysis of pools of isolated muscle fibers from freeze-dried human muscle biopsies.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Neonatal rat cardiomyocytes and cardiac fibroblasts were used to validate the protective effects of 6-gingerol in response to phenylephrine and transforming growth factor-β challenge.
[Acta Pharmacologica Sinica] |
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| Investigators developed a simple culture protocol under which the adult murine inguinal adipose tissue-derived stromal vascular fraction (Ad-SVF) reproducibly transdifferentiated into beating cardiomyocyte (CMs) without induction. The beating CMs showed the striated ventricular phenotype of cardiomyocytes and synchronised oscillation of the intracellular calcium concentration among cells on day 28 of Ad-SVF primary culture.
[Scientific Reports] |
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| The authors generated the first single-base resolution DNA methylome and transcriptome maps of porcine skeletal muscle across 27 developmental stages.
[Nucleic Acids Research] |
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| Myogenesis in human induced pluripotent stem cells with the Tet/ON-myogenic differentiation 1 gene was induced by culturing them in doxycycline-supplemented differentiation medium for seven days.
[Scientific Reports] |
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| | Scientists report the origin and molecular mechanisms of calcium signals that control the internal anal sphincter (IAS) basal tone, using a combination approach including a novel IAS slice preparation that retained cell arrangement and architecture as in vivo, 2‐photon imaging, and cell‐specific gene‐modified mice.
[Journal of Cellular Physiology] |
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| Investigators tested the hypothesis that TMEM16A, a calcium-activated chloride channel, contributed to modifications in arterial contractility during type 2 diabetes (T2D). They indicated that T2D increased TMEM16A mRNA in arterial smooth muscle cells and total and surface TMEM16A protein in resistance-size arteries of mice.
[American Journal of Physiology-Heart and Circulatory Physiology] |
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| Researchers investigated the mechanism by which sphingosine‐1‐phosphate contributes to age‐associated contractile dysfunction.
[Neurogastroenterology and Motility] |
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| The authors describe the current knowledge of the mechanisms allowing muscle stem cell fate transitions during regeneration and how it is altered in muscle disease.
[Skeletal Muscle] |
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| Sarepta Therapeutics, Inc. and Genevant Sciences announced a research collaboration and option agreement for the delivery of lipid nanoparticle-gene editing therapeutics in Sarepta’s pipeline for neuromuscular diseases.
[Sarepta Therapeutics, Inc.] |
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| April 21 – 23, 2021
Virtual |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| | The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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| | Hannover Medical School – Hannover, Germany |
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| | Mayo Clinic – Rochester, Minnesota, United States |
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| | Stanford University – Stanford, California, United States |
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| | National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States |
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