Muscle Cell News Volume 6.04 | Feb 1 2021

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    2020-02-01 | MUSCN 6.04


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.04 – 1 February, 2021
    TOP STORY

    FOS Licenses Early Events in Stem Cell Activation Driving Skeletal Muscle Regeneration

    Investigators identified a prominent FBJ osteosarcoma oncogene mRNA and protein signature in recently activated satellite cells that was rapidly, heterogeneously, and transiently induced by muscle damage.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Explore scientific events this February with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    Cyclophosphamide Arrhythmogenicity Testing Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

    Conduction properties and cytoskeleton structure of human induced pluripotent stem cell-derived cardiomyocytes obtained from a healthy donor under cyclophosphamide were evaluated.
    [Scientific Reports]

    Full Article

    iPSC-Derived Cardiomyocytes from Patients with Myotonic Dystrophy Type 1 Have Abnormal Ion Channel Functions and Slower Conduction Velocities

    Researchers developed a disease model using iPSC-derived cardiomyocytes (iPSC-CMs) from a healthy individual and two Myotonic Dystrophy type 1 patients with different CTG repeats lengths and clinical history.
    [Scientific Reports]

    Full Article

    Oxidized Phosphatidylcholines Trigger Ferroptosis in Cardiomyocytes during Ischemia/Reperfusion Injury

    Cardiomyocyte viability, bioenergetic response and calcium transients were determined in the presence of oxidized phosphatidylcholines (OxPCs). Fragmented OxPCs resulted in a decrease in cell viability with POVPC and PONPC having the most potent cardiotoxic effect in both a concentration and time dependent manner.
    [American Journal of Physiology-Heart and Circulatory Physiology]

    Abstract

    Transcription Factor Sp1 Ameliorates Sepsis-Induced Myocardial Injury via ZFAS1/Notch Signaling in H9C2 Cells

    Researchers revealed that the expressions of ZFAS1 and Sp1 were significantly reduced in LPS-treated H9C2 cells and primary cultured mouse neonatal cardiomyocytes. The downregulation of ZFAS1 and Sp1 were also found in cardiomyocytes obtained from LPS-challenged mice.
    [Cytokine]

    AbstractGraphical Abstract

    Shape-Morphing Fibrous Hydrogel/Elastomer Bilayers Fabricated by a Combination of 3D Printing and Melt Electrowriting for Muscle Tissue Regeneration

    Scientists report an approach for the fabrication of shape-changing bilayered scaffolds, which allowed the growth of aligned skeletal muscle cells, using a combination of 3D printing of hyaluronic acid hydrogel, melt electrowriting of thermoplastic polycaprolactone-polyurethane elastomer, and shape transformation.
    [ACS Applied Bio Materials]

    Abstract

    Mineralocorticoid Receptor in Smooth Muscle Contributes to Pressure Overload–Induced Heart Failure

    Deletion of mineralocorticoid receptor from smooth muscle cells attenuated transverse aortic constriction-induced heart failure with statistically significant improvements in ejection fraction, cardiac stiffness, chamber dimensions, intracardiac pressure, pulmonary edema, and exercise capacity.
    [Circulation-Heart Failure]

    Abstract

    MRTFA Overexpression Promotes Conversion of Human Coronary Artery Smooth Muscle Cells into Lipid-Laden Foam Cells

    Using human coronary artery smooth muscle cells researchers found that the transcriptional co-activator MRTFA promoted lipid accumulation via several mechanisms, including direct transcriptional control of LDL receptor, enhanced fluid-phase pinocytosis and reduced lipid efflux.
    [Vascular Pharmacology]

    Full ArticleGraphical Abstract

    Generate functional cardiomyocytes from hPSCs with the STEMdiff™ Cardiomyocyte Differentiation Kit
    REVIEWS

    Regulation of Cardiomyocyte Fate Plasticity: A Key Strategy for Cardiac Regeneration

    Scientists summarize the latest research progress in cardiac regeneration and heart repair through altering cardiomyocyte fate plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Perspectives on Skeletal Muscle Stem Cells

    The authors introduce recently developed technologies and the mechanistic insights they provide to the understanding of muscle stem cell biology, including the re-definition of quiescence and Galert states.
    [Nature Communications]

    Full Article

    INDUSTRY AND POLICY NEWS

    AskBio Adds CNS Gene Therapy Programs in Parkinson’s Disease and Multiple System Atrophy

    Asklepios BioPharmaceutical, Inc. announced that the clinical team from Brain Neurotherapy Bio, Inc. has joined AskBio to expand its clinical pipeline for the treatment of neurodegenerative disorders.
    [Asklepios BioPharmaceutical, Inc.]

    Press Release

    FEATURED EVENT

    The American Association for Cancer Research (AACR) Annual Meeting 2021: Week 2

    May 17 – 21, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Researcher III – Cardiovascular Disease

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Research Assistant – Myotonic Dystrophy

    Baylor College of Medicine – Houston, Texas, United States

    Professor or Associate Professor – Rheumatology

    The University of Utah School of Medicine – Salt Lake City, Utah, United States

    Research Scientist – Smooth Muscle and Enteric Nervous System

    Mayo Clinic – Rochester, Minnesota, United States

    Research Professional – Life Sciences

    Stanford University – Stanford, California, United States

    > See All Jobs

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