Muscle Cell News Volume 6.07 | Mar 1 2021

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    2021-03-01 | MUSCN 6.07


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.07 – 1 March, 2021
    TOP STORY

    CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice

    Researchers investigated the role of the lncRNA CARMN, independent from miR-143 and miR-145, as a potential regulator of vascular smooth muscle cell phenotypes in vitro and the consequences of its loss during the development of atherosclerosis in vivo.
    [Circulation Research]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    High Glucose Induces Drp1-Mediated Mitochondrial Fission via the Orai1 Calcium Channel to Participate in Diabetic Cardiomyocyte Hypertrophy

    High glucose induced cardiomyocyte hypertrophy, accompanied by abnormal mitochondrial morphology and function, and increased Orai1-mediated Ca2+ influx.
    [Cell Death & Disease]

    Full Article

    Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy

    Researchers developed a simple method that could drive cultured human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) toward maturity across a number of phenotypes, with the aim of utilizing mature hiPSC-CMs to model human cardiovascular disease.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Amelioration of Circadian Disruption and Calcium-Handling Protein Defects by Choline Alleviates Cardiac Remodeling in Abdominal Aorta Coarctation Rats

    In vitro analyses showed that choline ameliorated calcium overload, downregulated STIM1, Orai1, and TRPC6, and inhibited thapsigargin-induced store-operated Ca2+ entry and 1-oleoyl-2-acetyl-sn-glycerol-induced receptor-operated Ca2+ entry in angiotensin II-treated cardiomyocytes.
    [Laboratory Investigation]

    Abstract

    Optogenetic Current in Myofibroblasts Acutely Alters Electrophysiology and Conduction of Co-Cultured Cardiomyocytes

    Cardiac myofibroblasts were transduced with Channelrhodopsin-2, which allowed acute and selective increase of myofibroblast current, and plated on top of cardiomyocytes.
    [Scientific Reports]

    Full Article

    Oscillations of Delta-Like 1 Regulate the Balance between Differentiation and Maintenance of Muscle Stem Cells

    The authors demonstrated that oscillating delta-like 1 produced by myogenic cells is an indispensable Notch ligand for self-renewal of muscle stem cells in mice.
    [Nature Communications]

    Full Article

    Maintenance of Type 2 Glycolytic Myofibers with Age by Mib1-Actn3 Axis

    Researchers report that, with age, Mind bomb-1 (Mib1) plays an important role in skeletal muscle maintenance via proteasomal degradation-dependent regulation of α-actinin 3 (Actn3).
    [Nature Communications]

    Full Article

    Long Non-Coding RNA Mir22hg-Derived miR-22-3p Promotes Skeletal Muscle Differentiation and Regeneration by Inhibiting HDAC4

    Scientists identified a novel lncRNA, Mir22hg, that was significantly up-regulated during myoblast differentiation and was highly expressed in skeletal muscle. They validated that Mir22hg promoted the myoblasts differentiation, in vitro.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    Persistent COUP-TFII Expression Underlies the Myopathy and Impaired Muscle Regeneration Observed in Resistance to Thyroid Hormone-Alpha

    Researchers report that in murine myoblasts chicken ovalbumin upstream promoter-factor II (COUP-TFII) interacted with thyroid nuclear receptor alpha (THRA) and modulated THRA binding to thyroid response elements.
    [Scientific Reports]

    Full Article

    FOXF1 Is Required for the Oncogenic Properties of PAX3-FOXO1 in Rhabdomyosarcoma

    Investigators demonstrated that Forkhead Box F1 (FOXF1) transcription factor was uniquely expressed in fusion positive rhabdomyosarcoma (FP-RMS) and was required for FP-RMS tumorigenesis. The PAX3-FOXO1 directly bound to FOXF1 enhancers and induced FOXF1 gene expression.
    [Oncogene]

    Abstract

    A Hierarchical and Collaborative BRD4/CEBPD Partnership Governs Vascular Smooth Muscle Cell Inflammation

    While genomic deletion of BRD4-associated enhancer in smooth muscle cells in vitro decreased CCAAT enhancer binding protein delta (Cebpd) transcripts, BRD4 gene silencing also diminished Cebpd mRNA and protein, indicative of a BRD4 control over CEBPD expression.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractGraphical Abstract

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    REVIEWS

    A Double-Edged Sword of Immuno-Microenvironment in Cardiac Homeostasis and Injury Repair

    In adaptive immunity, effector T cells, especially Th17 cells, lead to the pathogenesis of cardiac fibrosis, including the distal fibrosis and scar formation. Cardiomyocytes protectors, Treg cells, inhibit reduce the inflammatory response, then directly trigger the regeneration of local progenitor cell via IL-10.
    [Signal Transduction and Targeted Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    Sarepta Therapeutics Announces FDA Approval of AMONDYS 45™ (Casimersen) Injection for the Treatment of Duchenne Muscular Dystrophy (DMD) in Patients Amenable to Skipping Exon 45

    Sarepta Therapeutics, Inc. announced that the FDA has approved AMONDYS 45. AMONDYS 45 is an antisense oligonucleotide from Sarepta’s phosphorodiamidate morpholino oligomer platform, indicated for the treatment of DMD in patients with a confirmed mutation amenable to exon 45 skipping.
    [Sarepta Therapeutics, Inc.]

    Press Release

    SHEPHERD Therapeutics and Mayo Clinic Announce Collaboration to Advance Research in Rhabdomyosarcoma Using SHEPHERD’s Precision-Oncology Platform, DELVE

    SHEPHERD Therapeutics announced a collaboration with the Mayo Clinic to advance research in rhabdomyosarcoma, a rare pediatric cancer with few treatment options.
    [SHEPHERD Therapeutics (Cision US Inc.)]

    Press Release

    FEATURED EVENT

    ISSCR 2021 Annual Meeting

    June 21 – 26, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Novel Molecular Targets for Treatment of Atherosclerosis

    Karolinska Institutet – Stockholm, Sweden

    PhD Position – Muscle Self-Organization

    Aix-Marseille University – Marseille, France

    Researcher III – Cardiovascular Disease

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Research Assistant – Myotonic Dystrophy

    Baylor College of Medicine – Houston, Texas, United States

    Professor or Associate Professor – Rheumatology

    The University of Utah School of Medicine – Salt Lake City, Utah, United States

    > See All Jobs

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