 | | Vol. 6.13 – 12 April, 2021 |
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| Scientists evaluated the therapeutic efficacy of the polyether ionophore salinomycin in patient derived cardiac fibroblasts and pre-clinical mouse models of ischemic and non-ischemic heart failure.
[Circulation Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors examined the regulatory effect of circular RNA HIPK3 (circHIPK3) during myocardial ischemia/reperfusion and investigated its mechanism in cardiomyocyte autophagy and apoptosis.
[Cell Death Discovery] |
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| Researchers investigated substrate metabolism in hiPSC-cardiomyocytes grown as a monolayer and in 3D, in porous collagen-derived scaffolds and in engineered heart tissue, by measuring rates of glycolysis and glucose and fatty acid oxidation, and changes in gene expression and mitochondrial oxygen consumption.
[Scientific Reports] |
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| The authors manipulated mitochondrial dynamics and found that increased mitochondrial fusion during myofibril assembly prevented mitochondrial intercalation in flight muscles.
[Nature Communications] |
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| Biofabrication tools can be applied to engineer human three-dimensional culture systems that complement current preclinical research models. Investigators described the development of the first in vitro three-dimensional model of myotonic dystrophy type 1 human skeletal muscle.
[Biofabrication] |
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| Investigators demonstrated that long non-coding RNA(lncRNA)-FKBP1C could bound with MYH1B and enhance its protein stability, thus affecting proliferation, differentiation of myoblasts and conversion of skeletal muscle fiber types.
[Cell Death Discovery] |
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| Researchers revealed miR-129-5p as a negative regulator of myogenic differentiation and slow fiber gene expression, affecting body metabolic homeostasis.
[American Journal of Physiology-Cell Physiology] |
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| Scientists identified transient receptor potential cation channel subfamily V member 1 (Trpv1)+ vascular smooth muscle cells as previously unidentified thermogenic adipocyte progenitors.
[Nature Metabolism] |
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| Researchers indicated that calcitonin gene-related peptide (CGRP) protected bladder smooth muscle cells from oxidative stress induced by high glucose in vitro, and inhibited the α-SM-actin expression decrease through inhibiting the intracellular p38 MAPK signaling pathway.
[Scientific Reports] |
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| The authors review various therapeutic strategies that use CRISPR/Cas to correct or bypass Duchenne muscular dystrophy mutations.
[Molecular Therapy-Methods & Clinical Development] |
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| Scientists present the most recent advances and improvements in cardiac tissue formation, including cardiomyocyte maturation and disease modeling.
[Stem Cells] |
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| Scholar Rock, a clinical-stage biopharmaceutical company focused on the treatment of serious diseases in which protein growth factors play a fundamental role, announced positive top-line data from the TOPAZ Phase II clinical trial evaluating apitegromab in patients with Type 2 and Type 3 SMA.
[Scholar Rock Inc.] |
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| Parent Project Muscular Dystrophy (PPMD) announced awards to three collaborative Certified Duchenne Care Center (CDCC) network projects totaling $450,000. Under PPMD’s 2021 CDCC Inter-Institutional Collaboration Grant Program, these grants will support the work of twenty centers from across the country working together to address a universal quality improvement or care need that can be advanced by collaborative guidance and training.
[Parent Project Muscular Dystrophy] |
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| July 8 – 10, 2021
Boston, Massachusetts, United States |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | Stanford University – Stanford, California, United States |
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| | Mount Sinai Health System – New York, New York, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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