Muscle Cell News Volume 6.19 | June 7 2021

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    2021-06-07 | MUSCN 6.19


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.19 – 7 June, 2021
    TOP STORY

    Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy

    Researchers examined whether pathogenic mutations perturbed the nanomechanics of cardiac myosin-binding protein C, which would compromise its modulatory mechanical tethers across sliding actomyosin filaments.
    [ACS Nano]

    AbstractGraphical Abstract
    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Visualization of β-Adrenergic Receptor Dynamics and Differential Localization in Cardiomyocytes

    Scientists employed highly sensitive florescence spectroscopy approaches, in combination with a florescent β‐AR antagonist, to determine the presence and dynamics of the endogenous receptors on the outer plasma membrane as well as on the T-tubular network of intact adult cardiomyocytes.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Remodeling of T-System and Proteins Underlying Excitation-Contraction Coupling in Aging versus Failing Human Heart

    Investigators showed that the transverse tubular system (t-system) and proteins underlying excitation-contraction coupling in cardiomyocytes were characteristically remodeled with age, characterized by t-system alterations and sarcolemmal dissociation of ryanodine receptor clusters.
    [npj Aging and Mechanisms of Disease]

    Full Article

    LncRNA H19 Governs Mitophagy and Restores Mitochondrial Respiration in the Heart through Pink1/Parkin Signaling during Obesity

    The effects of long non-coding RNA H19 (H19) on metabolic disorders, mitochondrial respiratory function, and mitophagy were investigated. Researchers suggested that DNA methylation-mediated downregulation of H19 expression played a crucial role in cardiomyocyte metabolic disorders.
    [Cell Death & Disease]

    Full Article

    Engineering Aligned Human Cardiac Muscle Using Developmentally Inspired Fibronectin Micropatterns

    Scientists identified cell–cell and cell-extracellular matrix interactions in the microenvironment of the early four-chambered vertebrate heart that drive cardiomyocyte organization and alignment.
    [Scientific Reports]

    Full Article

    Emergent Synchronous Beating Behavior in Spontaneous Beating Cardiomyocyte Clusters

    The authors investigated the dominant rule determining synchronization of beating intervals of cardiomyocytes after the clustering of mouse primary and human embryonic stem cell-derived cardiomyocytes.
    [Scientific Reports]

    Full Article

    Rebalancing Expression of HMGB1 Redox Isoforms to Counteract Muscular Dystrophy

    Investigators identified the alarmin high-mobility group box 1 (HMGB1) as a functional link between oxidative stress and inflammation in muscular dystrophies and demonstrated that the balance between HMGB1 redox isoforms dictated whether skeletal muscle was in an inflamed or regenerating state.
    [Science Translational Medicine]

    Abstract

    Prdm16-Mediated H3K9 Methylation Controls Fibro-Adipogenic Progenitors Identity during Skeletal Muscle Repair

    Using fibro-adipogenic progenitors as a model, researchers identified Prdm16 as a nuclear envelope protein that anchored H3K9-methylated chromatin in a cell-specific manner.
    [Science Advances]

    Full Article

    Acetylation of PAX7 Controls Muscle Stem Cell Self-Renewal and Differentiation Potential in Mice

    The acetyltransferase MYST1 stimulated by Acetyl-CoA, and the deacetylase SIRT2 stimulated by NAD+, were identified as direct regulators of PAX7 acetylation and asymmetric division in muscle stem cells.
    [Nature Communications]

    Full Article

    Human Muscle Stem Cells Are Refractory to Aging

    The authors used an established model of human muscle xenografting to test whether muscle samples taken from cadavers, of a range of ages, maintained their myogenic potential after being transplanted into immunodeficient mice.
    [Aging Cell]

    Full Article

    A Consolidated Aav System for Single Cut CRISPR Correction of a Common Duchenne Muscular Dystrophy Mutation

    Investigators devised a single-cut gene-editing method using a compact Staphylococcus aureus Cas9 to restore the open reading frame of exon 51, the most commonly affected out-of-frame exon in Duchenne muscular dystrophy.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Zinc Drives Vasorelaxation by Acting in Sensory Nerves, Endothelium and Smooth Muscle

    Researchers found that elevating cytoplasmic zinc using ionophores relaxed rat and human isolated blood vessels and caused hyperpolarization of smooth muscle membrane.
    [Nature Communications]

    Full Article

    Respiratory Syncytial Virus Induces β2-Adrenergic Receptor Dysfunction in Human Airway Smooth Muscle Cells

    Scientists investigated the effects of respiratory syncytial virus infection on the abundance and function of β2-adrenergic receptors in primary human airway smooth muscle cells derived from pediatric lung tissue.
    [Science Signaling]

    Abstract
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    REVIEWS

    Immune Cells and Immunotherapy for Cardiac Injury and Repair

    The authors review the immune response to heart injury, its contribution to cardiac fibrosis, and the potential of immune modifying therapies to affect cardiac repair.
    [Circulation Research]

    Full Article

    Intra- and Intercellular Signaling Pathways Associated with Drug-Induced Cardiac Pathophysiology

    Investigators discuss the homotypic and heterotypic cellular interactions that form the basis of intra- and intercellular cardiac signaling pathways, and how oncological agents disrupt these pathways, leading to heart failure.
    [Trends in Pharmacological Sciences]

    Abstract

    Next Generation of Heart Regenerative Therapies: Progress and Promise of Cardiac Tissue Engineering

    The authors outline key biology-inspired strategies reported to improve cardiomyocyte maturation features and current biofabrication approaches developed to engineer clinically relevant cardiac tissues.
    [NPJ Regenerative Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    New Muscles for the Bladder: Clinical Trial Evaluates Stem Cell Therapy for Congenital Incontinence

    A clinical trial to investigate whether muscle stem cell transplants may treat children with epispadias has been awarded approximately €4.3 million in funding from the Federal Ministry of Education and Research and the Berlin Institute of Health at Charité.
    [Berlin Institute of Health]

    Press Release

    Heartseed and Novo Nordisk Enter into Global Collaboration and Licence Agreement for Stem Cell-Based Therapy for Heart Failure

    Heartseed Inc. and Novo Nordisk A/S announced that they have entered into a collaboration and license agreement for the development, manufacturing, and commercialisation of Heartseed’s asset HS-001, an investigational cell therapy using purified cardiomyocytes derived from induced pluripotent stem cells, which is currently under development by Heartseed for the treatment of heart failure.
    [Heartseed, Inc.]

    Press Release
    FEATURED EVENT

    EMBO Workshop: Cell Size and Growth Regulation

    June 21 – 24, 2021
    Virtual

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    JOB OPPORTUNITIES

    Senior Scientist – Rare Cardiomyopathies

    Pfizer, Inc. – Cambridge, Massachusetts, United States

    Postdoctoral Fellow – Stem Cell Differentiation

    NYU Langone Medical Center – New York, New York, United States

    Research Scientist – Causes and Prevention of Cardiovascular Disease

    Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States

    Postdoctoral Position – Adaptive DNA Hydrogel Materials

    Johannes Gutenberg University Mainz – Mainz, Germany

    Director – The Roslin Institute

    The University of Edinburgh – Edinburgh, Scotland, United Kingdom

    > See All Jobs

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