|
| Researchers examined whether pathogenic mutations perturbed the nanomechanics of cardiac myosin-binding protein C, which would compromise its modulatory mechanical tethers across sliding actomyosin filaments. [ACS Nano] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Scientists employed highly sensitive florescence spectroscopy approaches, in combination with a florescent β‐AR antagonist, to determine the presence and dynamics of the endogenous receptors on the outer plasma membrane as well as on the T-tubular network of intact adult cardiomyocytes. [Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Investigators showed that the transverse tubular system (t-system) and proteins underlying excitation-contraction coupling in cardiomyocytes were characteristically remodeled with age, characterized by t-system alterations and sarcolemmal dissociation of ryanodine receptor clusters. [npj Aging and Mechanisms of Disease] |
|
|
|
| The effects of long non-coding RNA H19 (H19) on metabolic disorders, mitochondrial respiratory function, and mitophagy were investigated. Researchers suggested that DNA methylation-mediated downregulation of H19 expression played a crucial role in cardiomyocyte metabolic disorders. [Cell Death & Disease] |
|
|
|
| Scientists identified cell–cell and cell-extracellular matrix interactions in the microenvironment of the early four-chambered vertebrate heart that drive cardiomyocyte organization and alignment. [Scientific Reports] |
|
|
|
| The authors investigated the dominant rule determining synchronization of beating intervals of cardiomyocytes after the clustering of mouse primary and human embryonic stem cell-derived cardiomyocytes. [Scientific Reports] |
| |
|
|
| Investigators identified the alarmin high-mobility group box 1 (HMGB1) as a functional link between oxidative stress and inflammation in muscular dystrophies and demonstrated that the balance between HMGB1 redox isoforms dictated whether skeletal muscle was in an inflamed or regenerating state. [Science Translational Medicine] |
|
|
|
| Using fibro-adipogenic progenitors as a model, researchers identified Prdm16 as a nuclear envelope protein that anchored H3K9-methylated chromatin in a cell-specific manner. [Science Advances] |
|
|
|
| The acetyltransferase MYST1 stimulated by Acetyl-CoA, and the deacetylase SIRT2 stimulated by NAD+, were identified as direct regulators of PAX7 acetylation and asymmetric division in muscle stem cells. [Nature Communications] |
|
|
|
| The authors used an established model of human muscle xenografting to test whether muscle samples taken from cadavers, of a range of ages, maintained their myogenic potential after being transplanted into immunodeficient mice. [Aging Cell] |
|
|
|
| Investigators devised a single-cut gene-editing method using a compact Staphylococcus aureus Cas9 to restore the open reading frame of exon 51, the most commonly affected out-of-frame exon in Duchenne muscular dystrophy. [Molecular Therapy-Methods & Clinical Development] |
| |
|
|
| Researchers found that elevating cytoplasmic zinc using ionophores relaxed rat and human isolated blood vessels and caused hyperpolarization of smooth muscle membrane. [Nature Communications] |
|
|
|
| Scientists investigated the effects of respiratory syncytial virus infection on the abundance and function of β2-adrenergic receptors in primary human airway smooth muscle cells derived from pediatric lung tissue. [Science Signaling] |
|
|
|
|
| The authors review the immune response to heart injury, its contribution to cardiac fibrosis, and the potential of immune modifying therapies to affect cardiac repair. [Circulation Research] |
|
|
|
| Investigators discuss the homotypic and heterotypic cellular interactions that form the basis of intra- and intercellular cardiac signaling pathways, and how oncological agents disrupt these pathways, leading to heart failure. [Trends in Pharmacological Sciences] |
|
|
|
| The authors outline key biology-inspired strategies reported to improve cardiomyocyte maturation features and current biofabrication approaches developed to engineer clinically relevant cardiac tissues. [NPJ Regenerative Medicine] |
|
|
|
|
| A clinical trial to investigate whether muscle stem cell transplants may treat children with epispadias has been awarded approximately €4.3 million in funding from the Federal Ministry of Education and Research and the Berlin Institute of Health at Charité. [Berlin Institute of Health] |
|
|
|
| Heartseed Inc. and Novo Nordisk A/S announced that they have entered into a collaboration and license agreement for the development, manufacturing, and commercialisation of Heartseed’s asset HS-001, an investigational cell therapy using purified cardiomyocytes derived from induced pluripotent stem cells, which is currently under development by Heartseed for the treatment of heart failure. [Heartseed, Inc.] |
|
|
|
|
| June 21 – 24, 2021 Virtual |
|
|
|
|
|
| Pfizer, Inc. – Cambridge, Massachusetts, United States |
|
|
|
| NYU Langone Medical Center – New York, New York, United States |
|
|
|
| Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States |
|
|
|
| Johannes Gutenberg University Mainz – Mainz, Germany |
|
|
|
| The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
|
|
|
|