 | | Vol. 6.20 – 14 June, 2021 |
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| Scientists employed the sex-mismatched murine aortic graft model of graft arteriopathy in wild type and inducible smooth muscle-specific Tet2 knockout mice, and in vitro studies in vascular smooth muscle cells (VSMCs) to assess the role of TET methylcytosine dioxygenase 2 (TET2) in VSMC responses to IFNу, a cytokine elaborated by T cells that drives coronary allograft vasculopathy progression.
[Circulation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Cultured neonatal rat ventricular myocytes (NRVMs) were exposed to Tat-Beclin during simulated ischemia/reperfusion injury. ATG7 knockdown by siRNA in NRVMs was used to evaluate the role of autophagy.
[Circulation Research] |
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| Researchers suggested that the disease mechanism of childhood cardiomyopathy was due to accumulation of human BAG3P209L and mouse Bag3, causing sequestering of components of the protein quality control system and autophagy machinery leading to sarcomere disruption.
[Nature Communications] |
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| The authors focused on the P710R mutation that dramatically decreased in vitro motility velocity and actin-activated ATPase, in contrast to other β-cardiac myosin mutations. Human induced pluripotent stem cell–cardiomyocytes with the P710R mutation produced significantly increased force compared with isogenic control cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators identified a new compound that inhibited reactive oxygen species production in isolated mouse cardiomyocytes and improved cardiomyocyte contractility and contraction of whole retrogradely perfused hearts after a global ischemia period.
[Scientific Reports] |
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| Scientists investigated the role of late sodium current conductance in arrhythmias using adult primary cardiomyocytes and tissues from donor hearts.
[Scientific Reports] |
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| Investigators showed that expression of Homeobox-A (Hox-A) cluster genes accompanied with DNA hypermethylation of the Hox-A locus was robustly maintained in both somite-derived muscles and their associated satellite cells in adult mice, which recapitulated their embryonic origin.
[Science Advances] |
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| Researchers showed that targeted ablation of the histone chaperone HIRA in myogenic cells led to extensive transcriptional modifications, consistent with a role in maintaining skeletal muscle cellular identity.
[Nature Communications] |
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| Scientists used quantitative mass spectrometry to characterize intrinsic changes in the muscle stem cell (MuSC) proteome and remodeling of the MuSC niche during aging.
[Cell Reports] |
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| The authors investigated the involvement of TAM receptor kinases Mer and Axl in the muscle regeneration process by studying the muscle repair following cardiotoxin-induced injury in Mer−/− mice. In vitro inhibition of TAM kinase signaling in C2C12 myoblasts resulted in decreased viability and in impaired myotube growth.
[Cell Death & Disease] |
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| Scientists showed that CD38 deficiency in lymphocytes led to lack of protection against Ang II-induced vascular remodeling, suggesting that the effects of CD38 on Ang II-induced vascular remodeling may have relied primarily on vascular smooth muscle cells, not lymphocytes.
[Signal Transduction and Targeted Therapy] |
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| Researchers used asthma model bronchial smooth muscle cells to measure the biological behaviors of Histone deacetylase 4 (HDAC4)-mediated Kruppel-like factor 5 (KLF5)/Slug/CXC chemokine ligand-12 (CXCL12) axis on the development of asthma in regulation of airway inflammation and remodeling.
[Journal of Translational Medicine] |
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| Investigators discuss the multifaceted heart problem in the course of Duchenne muscular dystrophy, balancing the insights into basic science, translational efforts and clinical manifestation of dystrophic heart disease.
[Cellular and Molecular Life Sciences] |
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| The authors survey recent observations that are shedding more light on the nature of the interaction between circadian rhythms and the vascular system with implications for blood vessel disease.
[Current Opinion in Pharmacology] |
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| With a view to team science, the program ZonMw Open Competition is specifically aimed at innovative and groundbreaking combinations of two or more research groups.
[ZonMw] |
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| Heartseed, Inc. announced it has raised approx. $37 Million at Series C round. These funds will accelerate the initiation of a global clinical trial of HS-001, an allogeneic iPSC-derived, highly purified ventricular cardiomyocyte spheroids for heart failure.
[Heartseed, Inc.] |
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| September 24 – 27, 2021
Kloster Seeon, Germany |
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| | Hannover Medical School – Hannover, Germany |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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| | NYU Langone Medical Center – New York, New York, United States |
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| | Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States |
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| | Johannes Gutenberg University Mainz – Mainz, Germany |
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