 | | Vol. 6.22 – 28 June, 2021 |
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| Scientists used single-cell epigenomic analysis of hearts dynamically exposed to bromodomain and extra-terminal domain inhibitors to reveal a reversible transcriptional switch that underlay the activation of fibroblasts.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified thrombospondin 1 (Thbs1)-mediated PERK-eIF2α-ATF4-induced autophagy as a critical regulator of cardiomyocyte size in the stressed heart.
[Nature Communications] |
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| The authors challenged ventricular cardiomyocytes with epidermal growth factor (EGF)-like ligands and observed that selective activation of ErbB4 (the receptor for neuregulin 1), but not ErbB1 (the receptor for EGF), stimulated hypertrophy.
[Journal of Cellular Physiology] |
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| Expression of an IDH2 mutant mimicking deacetylation in cardiomyocytes promoted myocardial IDH2 activation, quenched mitochondrial reactive oxygen species (ROS), and alleviated post-myocardial infarction (MI) injury, whereas expression of an acetylation mimic in cardiomyocytes inactivated IDH2, exacerbated mitochondrial ROS overload, and aggravated post-MI injury.
[Acta Pharmacologica Sinica] |
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| Investigators developed a mouse model in which a mutated form of HIF1α could be inducibly expressed in cardiomyocytes, and suggested that loss of calcium/calmodulin dependent protein kinase II, gamma (CAMK2G) after myocardial infarction was HIF1-dependent and may have played an important role in the heart’s calcium signaling and response to hypoxia.
[Scientific Reports] |
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| Scientists developed agonist antibodies against muscle-specific kinase and showed that these antibodies restored neuromuscular synapse formation and prevented neonatal lethality and late-onset disease in Dok7CM mice.
[Nature] |
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| The authors identified fibroblasts that switched on a myogenic program and demonstrated that these dual identity cells fused into the developing muscle fibers along the muscle tendon junctions facilitating the introduction of fibroblast-specific transcripts into the elongating myofibers.
[Nature Communications] |
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| Researchers reported a global N6-Methyladenosine (m6A) modification pattern of goat skeletal muscle at two key development stages and identified that the m6A modification regulated the expression of the growth arrest and DNA damage response 45B (GADD45B) gene, which was involved in myogenic differentiation.
[Molecular Therapy-Nucleic Acids] |
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| Investigators applied cell-type-specific translational profiling to identify gene expression signatures underlying identity of muscle subsets including the lateral transverse muscles.
[Scientific Reports] |
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| Scientists generated transgenic (Tg) rabbits with smooth muscle cell-specific PGC1α overexpression and showed that these rabbits developed significantly less aortic atherosclerosis than their non-Tg littermates after high-cholesterol diet feeding, while total plasma cholesterol levels were similar.
[Circulation Research] |
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| Dental pulp stem cells seeded in biodegradable scaffolds and transplanted into immunodeficient mice generated mature human blood vessels invested with smooth muscle actin-positive mural cells.
[Cell Death & Disease] |
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| Investigators found that glial cell-derived neurotrophic factor (GDNF) was expressed in human lungs and increased in adult asthma, while human airway smooth muscle expressed GDNF and its receptors.
[Journal of Cellular Physiology] |
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| Researchers investigated the function of circ_0002984 in vascular smooth muscle cells (VSMCs) incubated by oxidized low-density lipoprotein (ox-LDL). Loss of circ_0002984 suppressed VSMC viability, cell cycle distribution, and migration capacity.
[Journal of Cellular and Molecular Medicine] |
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| The authors discuss the present findings and emerging concepts in epigenetic, inflammatory, and metabolic regulations and the consequences of the aging process.
[Signal Transduction and Targeted Therapy] |
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| Investigators explore the roles and interactions of DUX4 and PAX7 in facioscapulohumeral muscular dystrophy pathology and how the relationship between these two transcription factors deepens understanding via the immune system and muscle regeneration.
[EMBO Molecular Medicine] |
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| Scientists summarize the current knowledge on the cardiac signaling pathways modulated by two antineoplastic drugs highly used in the management of breast cancer, not only focusing on cardiomyocytes but also to broaden the knowledge of the potential impact on other cells found in the heart.
[Life Sciences] |
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| Vita Therapeutics announced the completion of an oversubscribed $32 million Series A. Vita’s lead therapy, VTA-100, is designed to be an autologous treatment that combines gene correction and induced pluripotent stem cell technology to help repair muscle cells.
[Vita Therapeutics] |
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| Idorsia Pharmaceuticals Ltd announced the initiation of the Phase III registration study “SOS-AMI” to evaluate the efficacy and safety of self-administered subcutaneous selatogrel, Idorsia’s P2Y12 receptor antagonist, in suspected acute myocardial infarction.
[Idorsia Pharmaceuticals Ltd] |
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| January 12 – 14, 2022
Shanghai, China |
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| | University Hospital of Muenster – Münster, Germany |
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| | Stanford University – Palo Alto, California, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Hannover Medical School – Hannover, Germany |
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| | University of Nebraska Medical Center – Omaha, Nebraska. United States |
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