Muscle Cell News Volume 6.34 | Oct 04 2021

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    2021-10-04 | MUSCN 6.34


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.34 – 4 October, 2021
    TOP STORY

    Cell Proliferation Fate Mapping Reveals Regional Cardiomyocyte Cell-Cycle Activity in Subendocardial Muscle of Left Ventricle

    Scientists found that the majority of cycling cardiomyocytes were positioned in the subendocardial muscle of the left ventricle, especially in the papillary muscles
    [Nature Communications]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    The circRNA CNEACR Regulates Necroptosis of Cardiomyocytes through Foxa2 Suppression

    Researchers found that the level of mmu_circ_000338, a cardiac- necroptosis-associated circRNA, was reduced in hypoxia-reoxygenation exposed cardiomyocytes and ischemia-reperfusion-injured mice hearts.
    [Cell Death & Disease]

    Full Article

    Human Cardiac Stem Cells Rejuvenated by Modulating Autophagy with MHY-1685 Enhance the Therapeutic Potential for Cardiac Repair

    Scientists employed MHY-1685, a novel mammalian target of rapamycin inhibitor, and examined its long-term priming effect on the activities of senile human cardiac stem cells (hCSCs) and the functional benefits of primed hCSCs after transplantation.
    [Experimental and Molecular Medicine]

    Full Article

    In Vitro CSC-Derived Cardiomyocytes Exhibit the Typical microRNA-mRNA Blueprint of Endogenous Cardiomyocytes

    The down-regulation of cell cycle genes and the up-regulation of the mature myofilament genes in cardiomyocytes in vitro (iCMs) reached intermediate levels between those of fetal and neonatal cardiomyocytes. Cardiomyo-miRs were up-regulated in iCMs.
    [Communications Biology]

    Full Article

    Co-Delivery of Fibrin-Laminin Hydrogel with Mesenchymal Stem Cell Spheroids Supports Skeletal Muscle Regeneration Following Trauma

    Mesenchymal stem cell (MSC) aggregation into spheroids was optimized in vitro based on cellular viability, spheroid size, and trophic factor secretion. The regenerative potential of the optimized MSC spheroid therapy was then investigated in a murine model of volumetric muscle loss injury.
    [Tissue Engineering and Regenerative Medicine]

    Abstract

    Endothelial Cell-Derived Pro-fibrotic Factors Increase TGF-β1 Expression by Smooth Muscle Cells in Response to Cycles of Hypoxia-Hyperoxia

    Researchers investigated the mechanisms by which pathological changes in the microvasculature direct fibrosis in the context of ischemia-reperfusion.
    [Biochimica Et Biophysica Acta-Molecular Basis of Disease]

    Full Article

    USP10 Exacerbates Neointima Formation by Stabilizing Skp2 Protein in Vascular Smooth Muscle Cells

    USP10 expression was detected in mouse arteries and increased after carotid ligation. In vitro data showed that USP10 deficiency reduced proliferation and migration of rat thoracic aorta smooth muscle cells and human aortic smooth muscle cells.
    [Journal of Biological Chemistry]

    Full Article

    The Proliferation and Migration of Atherosclerosis-Related HVSMCs Were Inhibited by Downregulation of lncRNA XIST via Regulation of the miR-761/BMP9 Axis

    Investigators found that lncRNA XIST was related to the abnormal proliferation and migration of human vascular smooth muscle cells (HVSMCs), and thus, the mechanism by which XIST regulated HVSMCs was further investigated.
    [Kaohsiung Journal of Medical Sciences]

    Full Article

    Circ-LAMP2 Regulates Aortic Smooth Muscle Cell Proliferation and Apoptosis in Thoracic Aortic Aneurysm via Modulation of Autophagy and NF-κB Pathway

    The apoptosis of smooth muscle cells is a major feature of thoracic aortic aneurysm. Scientists investigated the roles of circ_0091434 in human aortic smooth muscle cells.
    [Human Pathology]

    Abstract

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    REVIEWS

    Master Regulators of Skeletal Muscle Lineage Development and Pluripotent Stem Cells Differentiation

    The expression of genes MYF5, MRF4, MYOD is activated by muscle progenitors throughout development, in several waves of myogenic differentiation, constituting the embryonic, fetal and postnatal phases of muscle growth.
    [Cell Regeneration]

    Full Article

    INDUSTRY AND POLICY NEWS

    Baxter Announces US Approval and Launch of Ready-to-Use Cardiovascular Medicine Norepinephrine in Premix Formulation

    Baxter International, Inc. announced the US FDA approval and commercial launch of premix Norepinephrine Bitartrate in 5% Dextrose Injection.
    [Baxter International, Inc.]

    Press Release

    FEATURED EVENT

    The Calcium and Cell Function Conference

    October 26 – 28, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    PhD Student – Cardiovascular Disease

    Radboud University Medical Centre – Nijmegen, Netherlands

    Assistant Professor – Pediatric Heart Disease

    Harvard Medical School – Boston, Massachusetts, United States

    Research Fellow – Cardiovascular Research

    Queen’s University Belfast – Belfast, Ireland

    Postdoctoral Associate – Cardiovascular Biology and Disease Modeling

    Sanford Burnham Prebys Medical Discovery Institute – San Diego, California, United States

    Postdoctoral Positions – Organ Cross-Talk and Metabolic Disorders

    European Centre Study Diabetes – Strasbourg, France

    > See All Jobs

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