Therapeutically Engineered Induced Neural Stem Cells Are Tumor-Homing and Inhibit Progression of Glioblastoma Scientists provide evidence that transdifferentiation-derived induced neural stem cells (iNSCs) are an efficacious therapeutic strategy for brain cancer. They found that iNSCs genetically engineered with optical reporters and tumoricidal gene products retain the capacity to differentiate and induced apoptosis in co-cultured human glioblastoma cells. [Nat Commun] Full Article | Video The Hippo Signaling Pathway Maintains Quiescence in Drosophila Neural Stem Cells Researchers report that cell-contact inhibition of growth through the canonical Hippo signaling pathway maintains neural stem cell (NSC) quiescence. Loss of the core kinases hippo or warts leads to premature nuclear localization of the transcriptional co-activator Yorkie and initiation of growth and proliferation in NSCs. [Nat Commun] Full Article α-Synuclein–Induced Lysosomal Dysfunction Occurs through Disruptions in Protein Trafficking in Human Midbrain Synucleinopathy Models Investigators found that α-synuclein accumulation reduced lysosomal degradation capacity in human midbrain dopamine models of synucleinopathies through disrupting hydrolase trafficking. [Proc Natl Acad Sci USA] Abstract Inborn Errors of Long-Chain Fatty Acid β-Oxidation Link Neural Stem Cell Self-Renewal to Autism The authors report that neural stem cell (NSC)-autonomous insufficiencies in the activity of TMLHE, of CPT1A, or of fatty acid mobilization from lipid droplets reduced NSC pools in the mouse embryonic neocortex. [Cell Rep] Full Article | Graphical Abstract | Press Release A Synthetic Polymer Scaffold Reveals the Self-Maintenance Strategies of Rat Glioma Stem Cells by Organization of the Advantageous Niche Scientists used polymer microarrays for the rapid and efficient identification of glioma cancer stem cell niche mimicries and identified a urethane-based synthetic polymer, upon which two groups of niche components, namely extracellular matrices and iron were revealed. [Stem Cells] Abstract 5-HT2 Receptors Mediate Functional Modulation of GABAa Receptors and Inhibitory Synaptic Transmissions in Human iPS-Derived Neurons Human induced pluripotent stem cells (iPS) were differentiated into cells possessing featured physiological properties of cortical neurons. Whole-cell patch-clamp recording was used to examine the involvement of 5-HT2 receptors in functional modulation of GABAergic synaptic transmission. [Sci Rep] Full Article Reducing Central Serotonin in Adulthood Promotes Hippocampal Neurogenesis Scientists report that lowering serotonin (5-HT) level in adulthood is able to enhance adult hippocampal neurogenesis. They used tamoxifen-induced Cre in Pet1-CreERT2 mice to either deplete central serotonergic neurons or inactivate 5-HT synthesis in adulthood and explore the role of central 5-HT in adult hippocampal neurogenesis. [Sci Rep] Full Article Exogenous Neural Stem Cells Transplantation as a Potential Therapy for Photothrombotic Ischemia Stroke in Kunming Mice Model Researchers explored the transplantation of exogenous neural stem cells (NSCs) as the potential therapy for the photothrombotic ischemia stroke in a Kunming mice model. After stroke, mice receiving NSC transplantation demonstrated a better recovery of brain function during the neurobehavioral tests. [Mol Neurobiol] Abstract Ionizing Radiation Induces Altered Neuronal Differentiation by mGluR1 through PI3K-STAT3 Signaling in C17.2 Mouse Neural Stem-Like Cells To investigate the effects of ionizing radiation on C17.2 mouse neural stem-like cells and mouse primary neural stem cells, neurite outgrowth and expression of neuronal markers and neuronal function-related genes were examined. [PLoS One] Full Article NGF Sensitizes TrkA SH-SY5Y Neuroblastoma Cells to TRAIL-Induced Apoptosis Researchers report a novel pro-apoptotic function for nerve growth factor (NGF) and its tropomyosin-related kinase A (TrkA) receptor in sensitizing TNF-related apoptotis-inducing ligand (TRAIL)-resistant SH-SY5Y neuroblastoma cells to TRAIL-induced apoptosis, resulting in the abrogation of anchorage-independent tumorigenic growth in vitro. [Cell Death Discov] Full Article |