Adult Restoration of Shank3 Expression Rescues Selective Autistic-Like Phenotypes The authors generated a novel Shank3 conditional knock-in mouse model, and showed that re-expression of the Shank3 gene in adult mice led to improvements in synaptic protein composition, spine density and neural function in the striatum. [Nature] Abstract | Press Release Neuronal Differentiation Is Associated with a Redox-Regulated Increase of Copper Flow to the Secretory Pathway Scientists demonstrated that upon neuronal differentiation, cellular demand for copper increases, especially within the secretory pathway. Copper flow to this compartment is facilitated through transcriptional and metabolic regulation. [Nat Commun] Full Article | Press Release Targeted Axonal Import (TAxI) Peptide Delivers Functional Proteins into Spinal Cord Motor Neurons after Peripheral Administration Using an in vivo phage-display screen, researchers identified a peptide, targeted axonal import (TAxI), that enriched recombinant bacteriophage accumulation and delivered protein cargo into spinal cord motor neurons after intramuscular injection. [Proc Natl Acad Sci USA] Abstract The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory Scientists uncovered a surprising role of the anterograde molecular motor UNC-104/KIF1A as a key regulator of neural circuit deterioration in aging Caenorhabditis elegans. [Curr Biol] Abstract miRNA-128 Regulates the Proliferation and Neurogenesis of Neural Precursors by Targeting PCM1 in the Developing Cortex Researchers demonstrated that microRNA (miR)-128 regulates the proliferation and differentiation of neural progenitor cells by repressing pericentriolar material 1 (PCM1). [eLife] Full Article | Press Release C. elegans Body Cavity Neurons are Homeostatic Sensors that Integrate Fluctuations in Oxygen Availability and Internal Nutrient Reserves Researchers identify Caenorhabditis elegans body cavity neurons called URX(L/R) as central homeostatic sensors that integrate fluctuations in oxygen availability with internal metabolic state. [Cell Rep] Full Article | Press Release | Graphical Abstract Non-Canonical Features of the Golgi Apparatus in Bipolar Epithelial Neural Stem Cells Researchers report novel features of the Golgi apparatus, a central organelle for cell polarity, in mouse apical radial glia. [Sci Rep] Full Article Schizophrenia-Associated HERG Channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that Is Rescued through Proteasome Inhibition for High Throughput Screening Scientists characterized Kv11.1-3.1 cellular localization and showed decreased channel expression and cell surface trafficking relative to the Per-Ant-Sim-domain containing major isoform, Kv11.1-1A. [Sci Rep] Full Article Differentiation of Human Gingival Mesenchymal Stem Cells into Neuronal Lineages in 3D Bioconjugated Injectable Protein Hydrogel Construct for the Management of Neuronal Disorder Human gingival mesenchymal stem cells were, with due induction, differentiated to neuronal lineages to overcome the problems associated with birth tissue-related stem cells. [Exp Mol Med] Full Article Therapeutic Potential of Human Olfactory Bulb Neural Stem Cells for Spinal Cord Injury in Rats Investigators assessed the therapeutic potential of human olfactory bulb neural stem cells-GFP and their ability to survive, proliferate, differentiate and to restore lost sensory motor functions following their engraftment in spinal cord injury. [Spinal Cord] Abstract EmailAddress&u=http://www.stemcell.com/en/Products/All-Products/NeuroCult-SM1-Without-Vitamin-A.aspx?utm_source=cxn-ncn%26utm_medium=banner%26utm_campaign=nevitalaunch&t=(A)NCN10.06ii”> |