Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth Researchers showed that a strain of the Zika virus, MR766, serially passaged in monkey and mosquito cells efficiently infects human neural progenitor cells derived from induced pluripotent stem cells. [Cell Stem Cell] Abstract | Graphical Abstract | Press Release 1 | Press Release 2 Microglial P2Y12 Is Necessary for Synaptic Plasticity in Mouse Visual Cortex Scientists focused on the P2Y12 purinergic receptor, which is selectively expressed in non-activated microglia and mediates process motility during early injury responses. They found that disrupting this receptor alters the microglial response to monocular deprivation and abrogates ocular dominance plasticity. [Nat Commun] Full Article | Press Release Feedback Regulation of Apical Progenitor Fate by Immature Neurons through Wnt7–Celsr3–Fzd3 Signaling Researchers showed that neurogenesis is protracted and gliogenesis decreased in mice with mutations of genes Celsr3 and Fzd3. This phenotype is not due to gene inactivation in progenitors, but rather in immature cortical neurons. [Nat Commun] Full Article 4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from ALS Patient-Derived Induced Pluripotent Stem Cells Scientists investigated pathophysiological mechanisms underlying amyotrophic lateral sclerosis (ALS) using motor neurons differentiated from induced pluripotent stem cells derived from ALS patients carrying mutations in FUS or SOD1. [Stem Cells] Abstract WNT-C59, a Small-Molecule WNT Inhibitor, Efficiently Induces Anterior Cortex that Includes Cortical Motor Neurons from Human Pluripotent Stem Cells The authors compared two types of small molecules, C59 and XAV939, as substitutes for DKK1 to induce cortical neurons from pluripotent stem cells in serum-free embryoid body-like aggregate culture. [Stem Cells Transl Med] Abstract In Vivo Reprogramming Reactive Glia into iPSCs to Produce New Neurons in the Cortex following Traumatic Brain Injury The authors showed that retroviral mediated expression of four transcription factors, Oct4, Sox2, Klf4, and c-Myc, cooperatively reprogrammed reactive glial cells into induced pluripotent stem cell (iPSCs) in the adult neocortex following traumatic brain injury. [Sci Rep] Full Article TGFβ Signaling Regulates the Choice between Pluripotent and Neural Fates during Reprogramming of Human Urine Derived Cells Through sequential removal of individual compound from small molecule cocktail, scientists showed that A8301, a TGFβ signaling inhibitor, is sufficient to switch the cell fate from induced pluripotent stem cells into neural progenitor cells in OSKM-mediated human urine cells reprogramming. [Sci Rep] Full Article Knockout of Atg5 Delays the Maturation and Reduces the Survival of Adult-Generated Neurons in the Hippocampus To investigate the role of autophagy in adult hippocampal neurogenesis, the authors genetically deleted autophagy-related gene 5 (Atg5) that reduced autophagic flux and the survival of the progeny of dividing progenitor cells. [Cell Death Dis] Full Article Extremely Low-Frequency Electromagnetic Fields Promote In Vitro Neuronal Differentiation and Neurite Outgrowth of Embryonic Neural Stem Cells via Up-Regulating TRPC1 Scientists studied the potential effects of extremely low-frequency electromagnetic fields (ELF-EMFs) on embryonic neural stem cells (eNSCs). They exposed eNSCs to ELF-EMF for one, two, and three days with four hours per day. They found that eNSC proliferation and maintenance were significantly enhanced after ELF-EMF exposure in proliferation medium. [PLoS One] Full Article Targeted Activation of Primitive Neural Stem Cells in the Mouse Brain Investigators tested the self-renewal ability, differentiation capacity, and gene expression profile of pup-derived primitive neural stem cells (pNSCs) and found them each to be comparable to adult-derived pNSCs, including being GFAP–, nestinmid, Oct4+. [Eur J Neurosci] Abstract |