Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models Scientists showed in mouse models that complement and microglia mediate synaptic loss early in Alzheimer’s disease. C1q, the initiating protein of the classical complement cascade, is increased and associated with synapses before overt plaque deposition. [Science] Abstract | Press Release Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells Researchers examined the expression of receptors implicated in cell entry of several enveloped viruses including Zika virus across diverse cell types in the developing brain. [Cell Stem Cell] Full Article | Graphical Abstract | Press Release | Editorial Kappa Opioid Receptor Activation Alleviates Experimental Autoimmune Encephalomyelitis and Promotes Oligodendrocyte-Mediated Remyelination Scientists showed that genetic deletion of KOR exacerbates experimental autoimmune encephalomyelitis, whereas activating KOR with agonists alleviates the symptoms. KOR did not affect immune cell differentiation and function. Instead, it promoted oligodendrocyte differentiation and myelination both in vitro and in vivo. [Nat Commun] Full Article Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons The authors showed that the class I basic-helix-loop-helix (bHLH) proteins Daughterless and Tcf4 are expressed in postmitotic neurons in Drosophila melanogaster and mice, respectively, where they function to restrict neurite branching and synapse formation. [Cell Rep] Full Article | Graphical Abstract | Press Release Predegenerated Schwann Cells–A Novel Prospect for Cell Therapy for Glaucoma: Neuroprotection, Neuroregeneration and Neuroplasticity The authors created conditions to eliminate some of the barriers for precursor cells transplantation and allowed them to observe direct neuroprotective and pro-regenerative effects in ongoing optic neuropathy without additional modifications to the transplanted cells. [Sci Rep] Full Article Transplantation of Defined Populations of Differentiated Human Neural Stem Cell Progeny Researchers demonstrated a procedure for differentiating human neural precursor cells (hNPCs) in vitro, followed by isolation of the neuronal progeny. They transplanted undifferentiated hNPCs or a defined concentration of hNPC-derived neurons into mice, then compared these two groups with regard to their survival, proliferation and phenotypic fate. [Sci Rep] Full Article Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells Researchers showed that the lysophosphatidic acid receptor 1 is expressed by a defined population of type 1 stem cells and type 2a precursor cells in the adult mouse dentate gyrus. [Stem Cell Reports] Full Article Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis Scientists developed a protocol for the efficient generation of large, 3D-stratified retinal organoids that does not require evagination of optic-vesicle-like structures, which so far limited the organoid yield. [Stem Cell Reports] Abstract | Graphical Abstract | Press Release Long Non-Coding RNA C2dat1 Regulates CaMKIIδ Expression to Promote Neuronal Survival through the NF-κB Signaling Pathway following Cerebral Ischemia CAMK2D-associated transcript 1 (C2dat1) mRNA was upregulated in a time-dependent manner in mouse cortical penumbra after focal ischemic brain injury, which was accompanied by increased expression of CaMKIIδ at transcript and protein levels. The expression patterns of C2dat1 and CAMK2D were confirmed in mouse Neuro-2a cells in response to in vitro ischemia. [Cell Death Dis] Full Article Autophagy Activation Prevents Sevoflurane-Induced Neurotoxicity in H4 Human Neuroglioma Cells Investigators examined whether sevoflurane caused autophagy and its contributions to sevoflurane induced neuronal cell injury. [Acta Pharmacol Sin] Abstract |