Neural Cell News 11.45 November 15, 2017 | |
| |
TOP STORYThe authors found TRF1 upregulation in mouse and human glioblastoma multiforme (GBM). Brain-specific Trf1 genetic deletion in GBM mouse models inhibited GBM initiation and progression, increasing survival. Trf1 deletion increased telomeric DNA damage and reduced proliferation and stemness. [Cancer Cell] Abstract | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Investigators uncovered cold shock domain containing E1 (CSDE1) as a central post-transcriptional regulator of human embryonic stem cells identity and neurogenesis. [Nat Commun] Full Article The authors identified membralin as an endoplasmic-reticulum-associated degradation (ERAD) component and demonstrated a critical role for ERAD in Alzheimer’s disease pathogenesis. [Nat Commun] Full Article | Press Release Role of Estrogen Receptor Beta in Neural Differentiation of Mouse Embryonic Stem Cells To examine whether estrogen receptor beta (ERβ) influences differentiation of mouse embryonic stem cells (mESC) into neural lineages, scientists compared control and ERβ knockout mESCs at defined stages of neural development and examined the effects of an ERβ-selective ligand with a combination of global and targeted gene-expression profiling and the expression of key pluripotency markers. [Proc Natl Acad Sci USA] Abstract Researchers used induced pluripotent stem cells and neural progenitor cells derived from individuals with heterozygous 15q13.3 deletions and heterozygous 15q13.3 duplications to investigate the CHRNA7-dependent molecular consequences of the respective copy-number variants. [Am J Hum Genet] Abstract Widespread Translational Remodeling during Human Neuronal Differentiation Scientists induced forebrain neuronal differentiation of human embryonic stem cells and measured genome-wide RNA and translation levels with transcript-isoform resolution. They found that thousands of genes change translation status during differentiation without a corresponding change in RNA level. [Cell Rep] Full Article | Graphical Abstract Neural stem cell activity in the ventricular-subventricular zone (V-SVZ) decreases with aging, thought to occur by a unidirectional decline. However, by analyzing the V-SVZ transcriptome of male mice at 2, 6, 18, and 22 months, investigators found that most of the genes that change significantly over time show a reversal of trend, with a maximum or minimum expression at 18 months. [Stem Cell Reports] Full Article Naive-Like ESRRB+ iPSCs with the Capacity for Rapid Neural Differentiation Researchers modified several methods for converting human induced pluripotent stem cells (hiPSCs) into a naive state through the transgenic expression of several reprogramming factors. The resulting cells express the components of the core transcriptional network of mouse embryonic stem cells (mESCs), including ESRRB, at high levels, which suggests the existence of naive-state hiPSCs that are similar to mESCs. [Stem Cell Reports] Full Article | Graphical Abstract Scientists present a model designed with two subpopulations of primary hippocampal neurons with directed connectivity grown in a microfluidic device with asymmetric channels. They analyzed and compared neurite growth in the microchannels with various shapes that promoted growth dominantly in one direction. [Sci Rep] Full Article A proper dose of radial extracorporeal shock wave therapy (rESWT) enhanced neural stem cells (NSCs) augment via the PI3K/AKT pathway initially. Wnt/β-catenin and the Notch pathway played important roles in regulation of the long-term efficacy of rESWT. The authors revealed a novel approach to culture NSCs in vitro and support neurogenesis. [Sci Rep] Full Article | |
| |
REVIEWSMechanisms of Dietary Flavonoid Action in Neuronal Function and Neuroinflammation Scientists discuss potential mechanisms of flavonoid action in the brain, with a focus on two critical transcription factors: cAMP response element-binding protein and nuclear factor kappa-light-chain-enhancer of activated B cells. [Mol Aspects Med] Abstract Visit our reviews page to see a complete list of reviews in the neural cell research field. | |
| |
SCIENCE NEWSProclara Biosciences Presents New Preclinical Data Supporting Development of GAIM-Based Therapies Proclara Biosciences announced that new preclinical data supporting the development of general amyloid interaction motif (GAIM)-based therapies were presented. [Press release from Proclara Biosciences discussing research presented at the Society for Neuroscience Annual Meeting, Washington D.C.] Press Release Quanterix to Showcase New SR-X Ultra-Sensitive Biomarker Detection Systemâ„¢ Quanterix Corporation announced that the company featured its new SR-X Ultra-Sensitive Biomarker Detection Systemâ„¢. [Press release from Quanterix Corporation discussing research presented at the Society for Neuroscience Annual Meeting, Washington D.C.] Press Release Clinical Trial Finds Blood-Plasma Infusions for Alzheimer’s Safe, Promising Stanford University School of Medicine investigators have reported success in an early-phase clinical trial examining the safety, tolerability and feasibility of administering infusions of blood plasma from young donors to participants with mild to moderate Alzheimer’s disease. There were also some signs suggesting improvements in participants’ conditions. [Press release from Stanford Medicine discussing research presented at the 10th annual Clinical Trial on Alzheimer’s Disease conference, Boston] Press Release Ludwig Scientists Share Findings on Development and Treatment of Glioblastoma Ludwig Cancer Research released the scope of its participation at the Annual Meeting and Education Day of the Society for Neuro-Oncology. [Press release from Ludwig Cancer Research discussing research presented at the 2017 Society for Neuro-Oncology Annual Meeting, San Francisco] Press Release | |
| |
INDUSTRY NEWSThe Dementia Discovery Fund Attracts $50 Million Investment from Bill Gates The Dementia Discovery Fund announced a $50 million investment from Bill Gates. The investment is Gates’ first to accelerate progress toward disease modifying therapies for Alzheimer’s disease. [The Dementia Discovery Fund] Press Release Fortress Biotech, Inc. announced that the FDA has granted Cellvation’s CEVA101, autologous bone marrow-derived stem cells Regenerative Medicine Advanced Therapy designation for the treatment of traumatic brain injury. [Fortress Biotech, Inc.] Press Release Acorda Provides Update on Tozadenant Development Program Acorda Therapeutics, Inc. announced that it has increased the frequency of blood cell count monitoring for participants to weekly in its Phase III program of tozadenant for Parkinson’s disease. [Acorda Therapeutics, Inc.] Press Release Rodin Therapeutics announced that it has received funding support from The Michael J. Fox Foundation for Parkinson’s Research to advance enabling research for its emerging program in Parkinson’s disease. [Rodin Therapeutics] Press Release Mount Sinai Researcher Appointed as Next Generation Leader for the Allen Institute for Brain Science Denise Cai, PhD, Assistant Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai, has been selected as one of the Allen Institute for Brain Science’s 2017 Next Generation Leaders. [Mount Sinai] Press Release International Stem Cell Corporation announced the positive six months interim results of the first cohort of Parkinson’s disease patients receiving 30 million ISC-hpNSC cells in the ongoing clinical study. All patients in the first cohort are currently meeting the primary endpoint, which is safety. [International Stem Cell Corporation] Press Release The Michael J. Fox Foundation for Parkinson’s Research honored two researchers for their groundbreaking work to speed critical advances in Parkinson’s disease and dystonia research [The Michael J. Fox Foundation for Parkinson’s Research] Press Release Flex Pharma Reports Positive Topline Data from Exploratory Phase II Trial of FLX-787 in ALS Flex Pharma, Inc. announced positive topline data for FLX-787 from its randomized, double-blinded, placebo-controlled, cross-over Australian trial in amyotrophic lateral sclerosis (ALS) patients with frequent muscle cramps. [Flex Pharma, Inc.] Press Release | |
| |
POLICY NEWSAfrican Scientists Get Their Own Open-Access Publishing Platform Africa’s academy of science has announced that it will launch an open-access publishing platform — the first of its kind aimed exclusively at scientists on the continent. [Nature News] Editorial Graduate Students Face Alarming Tax Hike The last thing that graduate students need is a tax hike. But that is what many would face under a clause in the federal-tax-reform bill passed by the US House of Representatives. It will need to be reconciled with the Senate’s tax-reform bill (which retains many existing student tax benefits), and signed by the president. [Nature News] Editorial
| |
EVENTSNEW Gordon Research Conferences: Plasminogen Activation and Extracellular Proteolysis Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Faculty Position – Neurobiology (NYU Shanghai) NEW Chief Neuroscience Officer (Wyss Center for Bio and NeuroEngineering) NEW Postdoctoral Fellow/Associate – Developmental Neurobiology (SUNY Upstate Medical College) Associate Research Scientist – Neurophysiology (Columbia University) Associate Professor – Neurology (Massachusetts General Hospital & Harvard Medical School) Assistant Professor – Cellular and Molecular Neuroscience (University of British Columbia) Faculty Position – Spinal Cord and Brain Injury Research (Indiana University) PhD Students – Glioblastomas (Various Organizations) Faculty Members – Neuroscience (Mercer University) Postdoctoral Researcher – Stem Cell Differentiation (University of Oklahoma) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Neural Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|
Home Neural Cell News Volume 11.45 | Nov 15 2017