Neural Cell News 12.03 January 24, 2018 | |
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TOP STORYThe authors showed that increased expression of GluA1 AMPA receptor (AMPAR) subunit occurs in motor neurons (MNs) with C9ORF72 mutations that led to increased Ca2+-permeable AMPAR expression and results in enhanced selective MN vulnerability to excitotoxicity. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Triple S-Phase Labeling of Dividing Stem Cells Investigators present a method for triple S-phase labeling of the dividing cells, with a fourth label used to mark cells actively engaged in cell-cycle progression or to phenotype the dividing cells or their progeny. They applied this method to determine the parameters of neural stem cell division in the adult brain, to birth date up to four cohorts of dividing cells, and to reveal patterns of stem cell division in non-neural tissues. [Stem Cell Reports] Full Article Cylindromatosis Mediates Neuronal Cell Death In Vitro and In Vivo Scientists investigated the precise role of cylindromatosis (CYLD) in models of neuronal cell death in vitro and evaluated whether CYLD deletion affects brain injury in vivo. In vitro, downregulation of CYLD increased RIP1 ubiquitination, prevented RIP1/RIP3 complex formation, and protected neuronal cells from oxidative death. [Cell Death Differ] Full Article The authors report that Nestin loss triggers mitochondrial network remodeling and enhances oxidative phosphorylation in neural stem/progenitor cells treated with Nestin RNA interference. [Stem Cells] Abstract By RT-PCR, western blotting and immunocytochemistry experiments, investigators demonstrated that subventricular zone cells express molecular actors known to build up store-operated channels, namely TRPC1 and Orai1, as well as their activator STIM1. [Stem Cells] Abstract After closed head injury (CHI) mouse serum treatment, scientists found dramatic decreases in the cellular viabilities of differentiated induced neural stem cells (iNSCs). Following CHI mouse serum treatment, the death of astrocytes derived from iNSCs which were pre-treated with CHI mouse serum was significantly decreased. Meanwhile, the deposition of C3 and C5b-9 in these astrocytes was substantially reduced. [Cell Death Dis] Full Article The authors prospectively collected cerebrospinal fluid (CSF) from 36 patients with subarachnoid hemorrhage (SAH). The CSF was added to the culture medium of the rat neural stem cells neural stem cells to test the effects on proliferation (proliferation index (PI), percentage of Ki-67 immunoreactive cells). They correlated the PI with functional outcome based on the modified Rankin Scale at 3 months post-SAH. [Sci Rep] Full Article Allele-Specific Repression of Sox2 through the Long Non-Coding RNA Sox2ot Researchers showed that the RNA levels of Sox2ot and Sox2 are inversely correlated during neural differentiation of mouse embryonic stem cells. Through allele-specific enhanced transcription of Sox2ot in mouse Sox2eGFP knockin ESCs they demonstrated that increased Sox2ot transcriptional activity reduces Sox2 RNA levels in an allele-specific manner. [Sci Rep] Full Article Investigators characterized expression of FGAMS using multiple neuronal models. In differentiated human SH-SY5Y neuroblastoma cells, primary rat hippocampal neurons, and in whole mouse brain sections, FGAMS immunoreactivity was distributed within the neuronal cytoplasm. [J Neurochem] Abstract | Press Release | |
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REVIEWSThe Rise of Three-Dimensional Human Brain Cultures The author discusses how 3D brain culture approach can be used to understand unique features of the human brain and to gain insights into neuropsychiatric disorders. In addition, he considers the challenges faced by researchers in further improving and developing methods to probe and manipulate patient-derived 3D brain cultures. [Nature] Abstract Long Non-Coding RNAs, Novel Culprits, or Bodyguards in Neurodegenerative Diseases Researchers aim to highlight the progress of long non-coding RNA (lncRNA) research in the pathological and behavioral changes of neurodegenerative diseases. Specifically, they focus on how lncRNA dysfunctions are involved in the pathogenesis of Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. [Mol Ther Nucleic Acids] Full Article Visit our reviews page to see a complete list of reviews in the neural cell research field. | |
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INDUSTRY NEWSCerveau Technologies, Inc. Signs Research Agreement with University of Pittsburgh Cerveau Technologies Inc. announced an agreement with the University of Pittsburgh to support multiple projects over the next several years. [Cerveau Technologies Inc. (Business Wire, Inc.)] Press Release VBI Vaccines Announces Dosing of First GBM Patient in Phase I/IIa Clinical Study of VBI-1901 VBI Vaccines Inc. announced that the first patient has been dosed in a Phase I/IIa clinical study of VBI-1901 for the treatment of recurrent glioblastoma multiforme. The multi-center, open-label, two-part study will enroll up to 28 patients and is designed to evaluate safety, tolerability, and the optimal therapeutic dose level of VBI-1901. [VBI Vaccines Inc.] Press Release Boost for UNSW Brain Cancer and Joint Replacement Research A clinical trial of a new immunotherapy that will deliver a “toxin bomb” to brain cancer cells was one of two UNSW medical projects to receive funding. [University of New South Wales] Press Release | |
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POLICY NEWSGerman Scientists Hope for Windfall from Incoming Government Research budget could rise to 3.5% of gross domestic product if agreement struck during coalition talks holds. [Nature News] Editorial Nobel Laureate Suggests He Could Fall on Sword over Colleague’s Bogus Paper Shinya Yamanaka, who won a share of the 2012 Noble Prize in Physiology or Medicine for the discovery of induced pluripotent stem (iPS) cells, has suggested he could resign as director of Kyoto University’s Center for iPS Cell Research and Application in Japan over a fraudulent paper published by center researchers. [ScienceInsider] Editorial
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EVENTSNEW World Vaccine Congress Washington 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD/Postdoctoral Research Position – Neuroscience (Max Planck Society) Postdoctoral Fellowship – Neurodegeneration (Lund University) Postdoctoral Position – Neurology (University of Pittsburgh School of Medicine) Postdoctoral Associate – Cerebral Organoids (Weill Cornell Medicine) Research Assistant – Neurodegenerative Disease (Thomas Jefferson University) Postdoctoral Research Fellows – Bioengineering and Nanotechnology (The University of Queensland) PhD Scholarship – Neuroscience (University of Technology Sydney) Multiple Faculty Positions – Neuroscience and Neuroengineering (Tsinghua University) Postdoctoral Position – Brain Injury and Repair (University of Pennsylvania) Faculty Members – Neuroscience (Mercer University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Neural Cell News Volume 12.03 | Jan 24 2018