Neural Cell News 13.09 March 13, 2019 | |
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TOP STORYResearchers studied periventricular heterotopia by analyzing cerebral organoids derived from induced pluripotent stem cells of patients with mutations in the cadherin receptor–ligand pair DCHS1 and FAT4 or from isogenic knockout lines [Nat Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance Through chromatin immunoprecipitation and chromatin interaction analysis, the authors determined genome-wide SOX2-bound regions and Pol II-mediated long-range chromatin interactions in brain-derived neural stem cells. [Cell Stem Cell] Abstract | Press Release | Graphical Abstract Investigators identified 5′-deoxyadenosylcobalamin, a physiological form of the essential micronutrient vitamin B12 as a mixed-type allosteric inhibitor of leucine-rich repeat kinase 2 (LRRK2) kinase activity. [Cell Res] Abstract Scientists showed that tissue-specific depletion of the nucleoporin Seh1 causes dramatic myelination defects in the CNS. Although proliferation was not altered in Seh1-deficient oligodendrocyte progenitor cells, they failed to differentiate into mature oligodendrocytes, which impaired myelin production and remyelination after demyelinating injury. [Neuron] Abstract | Graphical Abstract Deciphering the Complex Role of Thrombospondin-1 in Glioblastoma Development The authors showed that the TGFβ canonical pathway transcriptionally regulates thrombospondin-1 (THBS1), through SMAD3 binding to the THBS1 gene promoter. THBS1 silencing inhibited tumor cell invasion and growth, alone and in combination with anti-angiogenic therapy. [Nat Commun] Full Article A Cell Type-Selective Apoptosis-Inducing Small Molecule for the Treatment of Brain Cancer Investigators report the identification of a small molecule, termed RIPGBM, from a cell-based chemical screen that selectively induced apoptosis in multiple primary patient-derived glioblastoma multiforme cancer stem cell cultures. [Proc Natl Acad Sci USA] Full Article The authors investigated the impact of TBC1D24 knockdown during the first stages of neuronal differentiation when axonal specification and outgrowth take place. In rat cortical primary neurons silenced for TBC1D24, they found defects in axonal specification, the maturation of axonal initial segment and action potential firing. [Cell Death Differ] Abstract Manganese Promotes the Aggregation and Prion-Like Cell-to-Cell Exosomal Transmission of α-Synuclein In cultured dopaminergic neuronal cells stably expressing wild-type human α-synuclein (αSyn), misfolded αSyn was secreted through exosomes into the extracellular medium upon Mn2+ exposure. [Sci Signal] Full Article Alcohol-Responsive Genes Identified in Human iPSC-Derived Neural Cultures Using human-induced pluripotent stem cells, scientists developed a neural cell culture model to identify the mechanisms of alcohol’s effects. [Transl Psychiatry] Full Article Researchers showed that CHD7 was up-regulated in human glioma tissues and they demonstrated that CHD7 knockout in LN-229 glioblastoma cells suppressed anchorage-independent growth and spheroid invasion in vitro. [Sci Rep] Full Article Investigators used computational fluid dynamics to simulate two multiplex culture conditions: steering plates on an orbital shaker and the use of a previously described bioreactor. [BMC Dev Biol] Full Article Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & ESC & iPSC News. | |
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REVIEWSHuntingtin Lowering Strategies for Disease Modification in Huntington’s Disease Huntington’s disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold great promise. [Neuron] Abstract Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality The authors discuss the rationale, opportunities, limitations, and progress in clinical adeno-associated viral (AAV) gene therapy. [Neuron] Full Article Visit our reviews page to see a complete list of reviews in the neural cell research field. | |
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SCIENCE NEWSThe SanBio Group announced its plan to make public the results of a global Phase II trial conducted in the US and Japan regarding the use of regenerative cell medicine SB623 as a treatment for chronic motor deficit from traumatic brain injury (TBI). [Press release from The SanBio Group (Business Wire, Inc.) discussing research to be presented at the 2019 American Association of Neurological Surgeons, San Diego] Press Release | |
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INDUSTRY NEWSSTEMCELL Technologies Wins Deloitte Best Managed Companies Award STEMCELL Technologies announced that the company has been selected as a winner of Canada’s Best Managed Companies program for 2019. Canada’s Best Managed Companies is the country’s leading business awards program, recognizing excellence in the management abilities and practices of Canadian owned and managed companies with revenues over $15 million. [STEMCELL Technologies Inc.] Press Release Neurotrope Inc. announced that it has initiated dosing in the final patient in the company’s randomized, double-blind, placebo-controlled, confirmatory Phase II clinical trial of Bryostatin-1 in moderate to severe Alzheimer’s disease patients not on memantine. [Neurotrope Inc.] Press Release Celgene Corporation announced that the company has submitted a Marketing Authorization Application to the European Medicines Agency (EMA) for ozanimod for the treatment of adults with relapsing-remitting multiple sclerosis. [Celgene Corporation] Press Release Parkinson’s Disease: Servier and Oncodesign Join Forces to Investigate New Line of Research Servier and Oncodesign have announced a strategic partnership for the research and development of potential drug candidates for Parkinson’s disease. [Servier] Press Release Seelos Therapeutics, Inc. announced that it has acquired an exclusive license to intellectual property owned by the Regents of the University of California pertaining to a technology that was created by researchers at the University of California (UC), Los Angeles. [Seelos Therapeutics, Inc. (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSIn a First, US Private Sector Employs Nearly as Many PhDs as Schools Do The job market for US science and engineering PhDs is about to pass a long-anticipated milestone. For decades, educational institutions have been the largest employer of PhDs. In 1997, for instance, they eclipsed private sector employment by 11 percentage points, according to the US National Science Foundation’s biennial Survey of Doctorate Recipients. [ScienceInsider] Editorial Ned Sharpless, Director of the National Cancer Institute, to Be Named Acting FDA Commissioner The Trump administration announced it would name Ned Sharpless, the director of the National Cancer Institute, the acting commissioner of the FDA next month. The announcement came just a week after the current commissioner, Scott Gottlieb, announced he plans to resign in early April. [STAT News] Editorial
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EVENTSNEW Gordon Research Conference: Modulation of Neural Circuits & Behavior Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Associate – Neurological Diseases (University of Utah) Senior Scientist – Neuroscience (STEMCELL Technologies Inc.) Research Associate – iPSC & Neurodegenerative Disease (TU Dresden) Researcher Position – Circuit & Behavioral Neuroscience (Instituto Italiano di Tecnologia) Postdoctoral Positions – Neurodegeneration (Van Andel Research Institute) Postdoctoral Position – Neurophysiology (University Medical Center Hamburg Eppendorf) Post Doctoral Scholarship – Brain Tumor Biology (Lund University) Postdoctoral Scholar – Brain Tumor Biology (Lund University) Faculty Positions – Developmental Neurosciences (Kent State University) Postdoctoral Scientist – Regenerative Plasticity of Neural Circuits (Cedars-Sinai Medical Center) Postdoctoral Position – Stem Cells & Neurodegeneration (Lund University) Assistant Member – Developmental Neurobiology (St. Jude Children’s Research Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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