Neural Cell News 13.45 November 20, 2019 | |
| |
TOP STORYBrain Cell Type-Specific Enhancer-Promoter Interactome Maps and Disease Risk Association Interactome maps connecting disease-risk variants in cell type-specific enhancers to promoters revealed an extended microglia gene network in Alzheimer’s disease. Deletion of a microglia-specific enhancer harboring Alzheimer’s disease-risk variants ablated BIN1 expression in microglia but not in neurons or astrocytes. [Science] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Genetic Identification of Vagal Sensory Neurons That Control Feeding Researchers used an approach for target-specific, single-cell RNA sequencing to generate a map of the vagal cell types that innervated the gastrointestinal tract. They showed that unique molecular markers identified vagal neurons with distinct innervation patterns, sensory endings, and function. [Cell] Abstract | Graphical Abstract Sensory Cortical Control of Movement Using optogenetics and pharmacogenetics in combination with in vivo and in vitro electrophysiology, scientists provided evidence for a direct corticospinal pathway from the primary somatosensory cortex that synapses with cervical excitatory neurons. [Nat Neurosci] Abstract Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment Researchers reported that pyramidal neurons in superficial layers of the prefrontal cortex were key elements causing disorganized oscillatory entrainment of local circuits in beta-gamma frequencies. Their abnormal firing rate and timing related to sparser dendritic arborization and lower spine density. [Neuron] Full Article | Graphical Abstract Mitochondrial Damage by α-Synuclein Causes Cell Death in Human Dopaminergic Neurons Scientists investigated deleterious effects of mitochondria-targeted α-synuclein (aSYN) in differentiated human dopaminergic neurons in comparison with wild-type aSYN overexpression and corresponding enhanced green fluorescent protein-expressing controls. [Cell Death Dis] Full Article Investigators examined the effects of endothelial cells-derived extracellular vesicles on neurons suffering from oxygen-glucose deprivation, which mimicked neuronal ischemia-reperfusion injury in human diseases. [Cell Death Dis] Full Article The authors generated glioblastoma cell models with overexpressed or silenced TRIP13 via lentivirus-mediated overexpression and RNAi methods. The biological role of TRIP13 in the proliferation, migration and invasion of glioblastoma cells has been further explored. [Br J Cancer] Abstract Knockdown of RNA binding protein EIF4A3, LINC00680 and TTN-AS1 impaired proliferation, migration and invasion as well as inhibiting growth of tumor in vivo and promoting apoptosis of glioblastoma cells. [Mol Ther Nucleic Acids] Abstract | Graphical Abstract Since the hippocampus is a major region affected in the Alzheimer’s disease brain, researchers performed hippocampal analysis and identified proteins that were differentially expressed between wild-type and 5XFAD model mice via LC-MS methods. [Exp Mol Med] Full Article The authors induced a reactive phenotype in human induced pluripotent stem cell-derived astrocytes and studied the inflammatory natures and effects of these cells on human neurons. [Sci Rep] Full Article Scientists deployed loss and gain of function strategies in N2a cells and primary cortical neurons in vitro, and demonstrated that gamma isoform of PKC (PKCγ) was not only important but necessary for neuronal differentiation, neurite outgrowth and axonal branching but not for axonal extension. [Sci Rep] Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & ESC & iPSC News. | |
| |
REVIEWSA Role for Spinal Cord Hypoxia in Neurodegeneration Damage to the vascular system of the spinal cord will develop after a traumatic event or as a result of pathology. Understanding the role of, and tissue response to, chronic hypoxia is particularly important, where inherent neural damage exacerbates the vulnerability of the nervous system to stressors including hypoxia. [Cell Death Dis] Full Article Researchers review the clinical characteristics, radiological manifestations and treatment of myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) optic neuritis. [Curr Opin Neurol] Full Article Visit our reviews page to see a complete list of reviews in the neural cell research field. | |
| |
INDUSTRY NEWSKIYATEC, Inc. and CarThera announced that they have entered into a clinical collaboration for the purpose of advancing innovation and improving treatments for patients diagnosed with glioblastoma. [KIYATEC, Inc.] Press Release CNS Pharmaceuticals Acquired Worldwide Rights for Brain Cancer Drug from Houston Pharmaceuticals CNS Pharmaceuticals, Inc. completed an agreement with Houston Pharmaceuticals, Inc. to obtain the rights to a worldwide, exclusive royalty-bearing, license for the chemical compound commonly known as Berubicin. [CNS Pharmaceuticals, Inc.] Press Release | |
| |
POLICY NEWSThe Science Institutions Hiring Integrity Inspectors to Vet Their Papers Some researchers have their manuscripts screened for errors before they go to journals. [Nature News] Editorial Foreign Interference Fears Prompt Guidelines for Australian Universities New guidelines will help Australian universities protect themselves against foreign interference, says the country’s government. The advice follows concerns that foreign groups or governments, such as the government of China, might be seeking to instigate campus activities that are against Australia’s interests. [Nature News] Editorial Violent Clashes at Hong Kong Universities Disrupt Research Three universities in Hong Kong have cancelled classes on campus for the rest of the term after violent clashes between police and protestors erupted in the grounds. At least another four universities have also cancelled classes – in some cases for the rest of the year – over safety concerns. [Nature News] Editorial
| |
EVENTSNEW Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Associate – Glia and Neuron Interaction (Howard Hughes Medical Institute) NEW Multiple Faculty Positions – Neuroscience and Neuroengineering (Tsinghua University) Faculty Position – Neuroimmunology (Mayo Clinic Comprehensive Cancer Center) PhD Student – Interneuron Developmental Dynamics (Flanders Institute for Biotechnology) Postdoctoral Researcher – Developmental Cognitive Neuroscience (Karolinska Institutet) Faculty Positions – Neuroscience and Behavioral Disorders (Duke-NUS Medical School) Research Associate – Adult CNS Progenitors (University of Cambridge) Faculty Positions – Brain Disorders (IDG/McGovern Institute for Brain Research) Postdoctoral Scholar – Neural Precursor Cells (University of South Florida) Faculty Positions – Autism and Neurodevelopmental Disorders (University of South Carolina) Faculty Positions – Brain Disorders (IDG/McGovern Institute for Brain Research) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Neural Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|