Neural Cell News Volume 14.07 | Feb 26 2020

TOP STORY

Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5

Scientists showed that CEP85L was required cell autonomously in vivo and in vitro for migration, that it localized to the maternal centriole, and that it formed a complex with many other proteins required for migration. [Neuron] Abstract

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Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini

Researchers showed that the non-canonical tubulin Tuba8, transiently expressed in cortical progenitors, drove differentiation of radial glial progenitors into apical intermediate progenitors, a more restricted progenitor type lacking attachment to the basal lamina. [Dev Cell] Full Article | Graphical Abstract

Gliomas Interact with Non-Glioma Brain Cells via Extracellular Vesicles

Investigators found that individual gliomas communicated with distinct sets of non-glioma cells. Transfer of genetic material was achieved mainly through extracellular vesicles, although cell fusion also played a minor role. [Cell Rep] Full Article | Graphical Abstract

Hedgehog Signaling Modulates Glial Proteostasis and Lifespan

Scientists investigated whether the Hedgehog signaling pathway was active during adult life in Drosophila melanogaster, and they uncovered a protective function for Hedgehog signaling in coordinating correct proteostasis in glial cells. [Cell Rep] Full Article | Graphical Abstract

Increased miR-34c Mediates Synaptic Deficits by Targeting Synaptotagmin 1 through ROS-JNK-p53 Pathway in Alzheimer’s Disease

The dramatically increased miR-34c negatively regulated synaptotagmin 1 (SYT1) expression by targeting the 3′-untranslated region of syt1 in Alzheimer’s disease. The expression of SYT1 protein was reduced by over expression of miR-34c in the HT-22 cells and vice versa. [Aging Cell] Full Article

Transcriptome Analyses Reveal Molecular Mechanisms Underlying Phenotypic Differences among Transcriptional Subtypes of Glioblastoma

Investigators revealed that the tumor cells in the mesenchymal subtype glioblastoma were under ER stress and that angiogenesis and the immune inflammatory response were both significantly elevated in this subtype. [J Cell Mol Med] Full Article

Memristive Synapses Connect Brain and Silicon Spiking Neurons

Researchers report on memristive links between brain and silicon spiking neurons that emulated transmission and plasticity properties of real synapses. [Sci Rep] Full Article

miR-29a Promotes the Neurite Outgrowth of Rat Neural Stem Cells by Targeting Extracellular Matrix to Repair Brain Injury

Scientists discovered that miR-29a regulated neural neurites in rat hippocampus neural stem cells (NSCs). Overexpression of miR-29a reduced the cell soma area and promoted the neurite outgrowth of NSCs. [Stem Cells Dev] Abstract

A Cell and Tissue Specific Weakness of the Protein Homeostasis System Underlies Brain Vulnerability to Protein Aggregation

To understand the causes of the selective cell and tissue vulnerability to the formation of these deposits, researchers analyzed the ability of different cell and tissue types to respond in the absence of disease to the presence of high levels of aggregation-prone proteins. [iScience] Abstract | Graphical Abstract | Full Article

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Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration

Scientists discuss the role of axonal degeneration in neurodegenerative disorders, with a focus on sterile alpha and TIR motif containing 1 (SARM1) and the discovery of its intrinsic enzymatic function. [Trends Pharmacol Sci] Full Article

Bacterial Peptidoglycan as a Driver of Chronic Brain Inflammation

Researchers highlight current insights into the roles of peptidoglycan as a determinant of brain inflammation, notably in multiple sclerosis and its experimental autoimmune encephalomyelitis models. [Trends Mol Med] Abstract

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Novartis Announces FDA and EMA Filing Acceptance of Ofatumumab, a Novel B-Cell Therapy for Patients with Relapsing Forms of Multiple Sclerosis (RMS)

Novartis, Inc. announced that both the FDA and European Medicines Agency have accepted the company’s Supplemental Biologics License Application and Marketing Authorization Application, respectively, for ofatumumab for the treatment of RMS in adults. [Novartis, Inc.] Press Release

WPD Pharmaceuticals’ STAT3 Inhibitor Received FDA Approval of IND Status in Pediatric Brain Cancer Trial

Through Moleculin Biotech, Inc., WPD’s license partner, the WP1066 drug candidate received FDA approval for Investigational New Drug status to be used in a Phase I clinical trial for the treatment of children with recurrent or refractory malignant brain tumors. [WPD Pharmaceuticals Inc.] Press Release

Federal Judge Rules Clinical Trial Sponsors Must Publish a Decade’s Worth of Missing Data

For years, government research agencies have misinterpreted a law that requires them to collect and post clinical trial data, a federal judge ruled this week, leaving behind a ten year gap in data that now must be made publicly available. [STAT News] Editorial

Contract Offers Unprecedented Look at Google Deal to Obtain Patient Data from the University of California

It was the fall of 2015 when researchers from Google and the University of California, San Francisco, first sat down together to hash out a research collaboration in an area that has since exploded with activity: using artificial intelligence to make predictions in the hospital. [STAT News] Editorial

NEW Advanced Therapies in Neurodegeneration: Bridging Neuroscience, Bioengineering and Optogenetics
April 29-30, 2020
Lisbon, Portugal

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NEW Associate Professor – Visual Neuroscience (Dalhousie University)

Postdoctoral Associate – Traumatic Brain Injury (University of Miami)

Postdoctoral Position – Neurodevelopment and Brain Tumors (Mount Sinai)

Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University)

Branch Chief – Neuroscience Research (National Institutes of Health)

Postdoctoral Research Fellowship – Neuroscience and Stem Cells (Black Family Stem Cell Institute)

Faculty Position – Neuroimmunology (St. Jude Children’s Research Hospital)

Postdoctoral Fellow – Vascular Dysfunction in Neurodegeneration (Translational Neurology Group)

Postdoctoral Research Positions – Alzheimer’s Disease and Traumatic Brain Injury (University of Colorado Boulder)

Postdoctoral Researcher – Neurodegenerative Diseases and Cancer (University of Pennsylvania)

Postdoctoral Associate – Neuron Diversity Mechanisms in Brain Development (Howard Hughes Medical Institute)

Postdoctoral Associate – Glia and Neuron Interaction (Howard Hughes Medical Institute)

Faculty Positions – Brain Disorders (IDG/McGovern Institute for Brain Research)

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