Neural Cell News 14.20 May 27, 2020 | |
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TOP STORYStructures of α-Synuclein Filaments from Multiple System Atrophy Investigators showed that α-synuclein inclusions from the brains of individuals with multiple system atrophy were made of two types of filament, each of which consisted of two different protofilaments. [Nature] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors performed rapid structured illumination microscopy and enhanced resolution confocal microscopy to study spatiotemporal spinule dynamics in cortical pyramidal neurons. [Neuron] Abstract | Graphical Abstract | Press Release Scientists performed a quantitative proteomic screen to identify cytosolic proteins that interacted with a canonical RNA G-quadruplexes in its folded and unfolded conformation. [Nat Commun] Full Article Molecular signaling of resistance in therapy resistant residual cells was identified using RNA sequencing, genetic and pharmacological perturbations, overexpression systems, molecular and biochemical assays. [Neuro Oncol] Abstract Inhibition of PKR-like endoplasmic reticulum kinase (PERK) signaling with its downstream inhibitor ISRIB, but not with the direct PERK kinase inhibitor GSK2606414, significantly enhanced the survival of G93A SOD1-expressing neurons. [Cell Death Dis] Full Article Scientists found that LncRNA SOX2OT was increased in temozolomide-resistant cells and recurrent glioblastoma patient samples, and abnormal expression was correlated with high risk of relapse and poor prognosis. [Cell Death Dis] Full Article Researchers demonstrated that co-culture of microglia-like cell precursors with human glia and neurons enhanced transcriptional resemblance of microglia-like cells to ex vivo microglia. [Stem Cell Reports] Full Article The authors demonstrated that medulloblastoma cells were capable of forming tumor spheroids in vitro under optimized conditions, which could be further passaged and cryopreserved. [Lab Invest] Abstract Inhibition of miR-181a-5p protected the hippocampus against epilepsy, including hippocampal insults, neuronal apoptosis, astrocyte and microglia activation, neuroinflammation, oxidative stress, mitochondrial function, and cognitive dysfunction. [Lab Invest] Abstract Scientists investigated the anticancer effects of avasimibe on human glioblastoma cells and the underlying mechanisms. [Acta Pharmacol Sin] Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & ESC & iPSC News. | |
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REVIEWSGAD Antibodies in Neurological Disorders – Insights and Challenges The authors provide recommendations for assessing the association between a neurological syndrome and the presence of glutamic acid decarboxylase (GAD) antibodies, and they critically review the evidence on the pathogenicity of GAD antibodies. [Nat Rev Neurol] Abstract Visit our reviews page to see a complete list of reviews in the neural cell research field. | |
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INDUSTRY NEWSTriplet Therapeutics Initiates SHIELD HD Natural History Study of Huntington’s Disease Triplet Therapeutics, Inc. announced it has initiated a natural history study of Huntington’s disease to assess clinical outcomes and biomarkers that will inform upcoming interventional clinical trials. [Triplet Therapeutics, Inc. (BusinessWire, Inc.)] Press Release Bristol Myers Squibb announced that the European Commission has approved Zeposia for the treatment of adult patients with relapsing remitting multiple sclerosis with active disease as defined by clinical or imaging features. [Bristol Myers Squibb] Press Release | |
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POLICY NEWSUS Lawmakers Unveil Bold $100 Billion Plan to Remake NSF The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial They Redesigned PubMed, a Beloved Website. It Hasn’t Gone Over Well Unfortunately for PubMed’s caretakers, a sweeping redesign unveiled this week has left many PubMed users fuming-and airing their sometimes curse-laden complaints on social media. [ScienceInsider] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Genes in Neural Circuits (Cold Spring Harbor Laboratory) Postdoctoral Position – Electron Microscopy of Brain Circuits (Technical University of Munich) Investigator Scientist – Brain Neuron Research (The MRC Laboratory of Molecular Biology) Postdoctoral Position – Ferroptosis Research in Neuroblastoma (Flanders Institute for Biotechnology) Postdoctoral Associate – Neurobiology Research (Cornell University) Postdoctoral Position – Neuroscience (Linköping University) Associate Professor – Molecular Neurobiology (Aarhus University) Researcher Position – Transcriptional Activity in Brain Diseases (Italian Institute of Technology) Postdoctoral Position – Brain and Disease Research (Flanders Institute for Biotechnology) Postdoctoral Fellow – Neurogenerative Disease (Johns Hopkins University School of Medicine) Scientist – Oligonucleotide Therapies for Neurological Disorders (Deep Genomics Inc.) Faculty Positions – Brain Disorders (IDG/McGovern Institute for Brain Research) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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